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中华脑血管病杂志(电子版)

中华脑血管病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 341 -345. doi: 10.11817/j.issn.1673-9248.2020.06.005

所属专题： 文献；

论著

立体定向放射外科治疗海绵窦海绵状血管瘤的安全性及有效性
孙振伟1, 樊跃飞1, 韩超1, 顿志平1,†()   
  1. 1. 250033　山东济南，山东大学第二医院神经外科
  • 收稿日期:2020-07-02 出版日期:2020-12-01
  • 通信作者: 顿志平

The safety and efficacy of stereotactic radiosurgery for cavernous sinus hemangioma

Zhenwei Sun1, Yuefei Fan1, Chao Han1, Zhiping Dun1,†()   

  1. 1. Department of Neurosurgery, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China
  • Received:2020-07-02 Published:2020-12-01
  • Corresponding author: Zhiping Dun
  • About author:
    Corresponding author: Dun Zhiping, Email:
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孙振伟, 樊跃飞, 韩超, 顿志平. 立体定向放射外科治疗海绵窦海绵状血管瘤的安全性及有效性[J/OL]. 中华脑血管病杂志(电子版), 2020, 14(06): 341-345.

Zhenwei Sun, Yuefei Fan, Chao Han, Zhiping Dun. The safety and efficacy of stereotactic radiosurgery for cavernous sinus hemangioma[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(06): 341-345.

目的

通过系统性综述，回顾性分析立体定向放射外科治疗海绵窦海绵状血管瘤的安全性及有效性。

方法

利用PubMed、Embase检索相关文献，通过对文章标题、摘要、全文阅读后筛选文献15篇，共收集155例患者资料，平均肿瘤体积14.7 cm3，无症状患者22例，有症状患者133例，其中39例患者有动眼神经麻痹，外展神经和视神经损伤患者分别有31例和28例。利用SPSS对文中数据进行统计学分析，分析其疗效及安全性。

结果

133例有症状患者经过立体定向放射外科治疗，20例症状消失，97例症状改善，其余14例患者情况稳定。影像学结果显示肿瘤消失患者9例，明显缩小101例，部分缩小27例，无变化13例。除2例患者外，其余患者均无不良反应。统计学结果显示患者不同症状缓解情况患者肿瘤体积及边缘剂量之间差异均无统计学意义（P＞0.05），病灶影像学变化不同患者的肿瘤体积及边缘剂量之间比较，差异均无统计学意义（P＞0.05）。单独接受立体定向放射外科治疗后患者临床症状缓解率高于手术联合立体定向放射外科治疗组患者（96.8% vs 69.4%），差异具有统计学意义（χ2=15.367，P＜0.001）。

结论

立体定向放射外科是治疗海绵窦海绵状血管瘤的有效治疗方法。

关键词: 海绵窦海绵状血管瘤, 立体定向放射外科, 有效性, 安全性
Objective

To perform a systematic review and meta-analysis for exploring the safety and efficacy of stereotactic radiosurgery for cavernous sinus hemangioma.

Methods

Fifteen studies were identified through a literature search and the information of 155 patients was recorded. Clinical outcomes and the tumor response were the primary measurements of interest. The mean tumor volume was 14.7 cm3. Twenty-two patients (14.2%) were asymptomatic and 133 (85.8%) were symptomatic. Thirty-nine (35.8%) patients had cranial nerve III palsy while 31 (28.4%) patients and 28 (25.7%) patients had VI and II cranial nerve palsy, respectively.

Results

Among the 133 patients with symptoms, symptoms of 20 (15.3%) patients disappeared while 97 (74.0%) of them improved after the treatment. The symptoms of the remaining patients (10.79%, 14/131) were stable. The imaging results showed that there were 9 patients with tumor disappearance, 101 patients with significant reduction of tumor volume, 27 patients with partially reduced tumor volume and 13 patients without change. No adverse effects were observed in these patients except two patients. The improvement of symptom is not related to the volume or isodose (P＞0.05). The shrunk of volume is not related to the volume or isodose (P＞0.05). The improvement of symptoms of patients was better for patients with radiosurgery alone than the patients received surgery before radiosurgery (96.8% vs 69.4%, χ2=15.367, P＜0.001).

Conclusion

The meta-analysis indicated the stereotactic radiosurgery could be the optimal treatment therapy for cavernous sinus hemangioma.

Key words: Cavernous sinus hemangioma, Stereotactic radiosurgery, Efficacy, Safety
表1 纳入的15篇文献患者临床资料汇总
文献 病例数 年龄（岁） 肿瘤体积（cm3） 随访时间（月） 边缘剂量（Gy） 体积缩小率（%）
平均 范围 平均 范围 平均 范围 平均 范围 平均 范围
Kida等[6] 3 51.3 38~66 5.3 1.5~11.1 27 12~36 15.7 14~17 56.7 54~59
Seo等[7] 1 79 79 8.5 8.5 24 24 15 15 100 100
Thompson等[8] 3 27.3 14~44 4.5 2.8~5.6 12 6~18 16 14~19 56.3 0~86
Peker等[9] 5 43.8 37~60 5.0 3.8~6.2 32.8 6~52 15 14~16 68.2 61~79
Ivanov等[10] 3 52.7 38~67 12.7 6.4~19 12 12 11.7 10~13 60 45~75
Khan等[11] 7 37.9 14~56 6.4 2.5~10.8 75.3 40~111 14.8 12.5~19.0 66.8 0~100
Chou等[12] 7 43.7 26~77 9.9 3~23.1 50.7 6~156 12.5 12.5 81.6 56~100
Yamamoto等[13] 30 53.3 19~78 11.5 1.5~51.4 53.2 12~138 13.5 8~17 - -
Murphy[14] 1 15 15 1.5 1.5 16 16 16 16 100 100
Anqi等[15] 15 40.4 20~77 29.3 8~138 9.5 2~27 13.4 10~16 41.4 0~83.5
Bansal等[16] 9 43 27~50 6.4 2.3~13.3 17 6~35 16.9 12~22.3 - -
Song等[17] 19 52.3 35~73 6.1 0.3~32.3 28.4 6~84 14.4 11.5~16 73.9 48~100
Park等[18] 13 62.3 44~76 2.7 1.3~8.0 90 16~164 12.9 12~14 63 6~92
Wang等[19] 32 49.1 21~73 30.5 2.5~78.6 30.3 12~67 14.5 11~16 74.4 11.6~100
Xu等[20] 7 51.6 39~64 12.5 3.8~33.2 20.3 6~40 13.6 10~15 76.0 43.8~92.5
1
Linskey ME, Sekhar LN. Cavernous sinus hemangiomas: a series, a review, and an hypothesis [J]. Neurosurgery, 1992, 30(1): 101-108.
2
Hashimoto M, Yokota A, Ohta H, et al. Intratumoral injection of plastic adhesive material for removal of cavernous sinus hemangioma. Technical note [J]. J Neurosurg, 2000, 93(6): 1078-1081.
3
Gonzalez LF, Lekovic GP, Eschbacher J, et al. Are cavernous sinus hemangiomas and cavernous malformations different entities? [J]. Neurosurg Focus, 2006, 21(1): e6.
4
Lanzino G, Hirsch WL, Pomonis S, et al. Cavernous sinus tumors: neuroradiologic and neurosurgical considerations on 150 operated cases [J]. J Neurosurg Sci, 1992, 36(4): 183-196.
5
Jamjoom AB. Response of cavernous sinus hemangioma to radiotherapy: a case report [J]. Neurosurg Rev, 1996, 19(4): 261-264.
6
Kida Y, Kobayashi T, Mori Y. Radiosurgery of cavernous hemangiomas in the cavernous sinus [J]. Surg Neurol, 2001, 56(2): 117-122, discussion 122-123.
7
Seo Y, Fukuoka S, Sasaki T, et al. Cavernous sinus hemangioma treated with gamma knife radiosurgery: usefulness of SPECT for diagnosis--case report [J]. Neurol Med Chir (Tokyo), 2000, 40(11): 575-580.
8
Thompson TP, Lunsford LD, Flickinger JC. Radiosurgery for hemangiomas of the cavernous sinus and orbit: technical case report [J]. Neurosurgery, 2000, 47(3): 778-783.
9
Peker S, Kilic T, Sengoz M, et al. Radiosurgical treatment of cavernous sinus cavernous haemangiomas [J]. Acta Neurochir (Wien), 2004, 146(4): 337-341, discussion 340.
10
Ivanov P, Chernov M, Hayashi M, et al. Low-dose gamma knife radiosurgery for cavernous sinus hemangioma: report of 3 cases and literature review [J]. Minim Invasive Neurosurg, 2008, 51(3): 140-146.
11
Khan AA, Niranjan A, Kano H, et al. Stereotactic radiosurgery for cavernous sinus or orbital hemangiomas [J]. Neurosurgery, 2009, 65(5): 914-918, discussion 918.
12
Chou CW, Wu HM, Huang CI, et al. Gamma knife surgery for cavernous hemangiomas in the cavernous sinus [J]. Neurosurgery, 2010, 67(3): 611-616, discussion 616.
13
Yamamoto M, Kida Y, Fukuoka S, et al. Gamma Knife radiosurgery for hemangiomas of the cavernous sinus: a seven-institute study in Japan [J]. J Neurosurg, 2010, 112(4): 772-779.
14
Murphy RK, Reynolds MR, Mansur DB, et al. Gamma knife surgery for a hemangioma of the cavernous sinus in a child [J]. J Neurosurg Pediatr, 2013, 11(1): 74-78.

URL    
15
Anqi X, Zhang S, Jiahe X, et al. Cavernous sinus cavernous hemangioma: imaging features and therapeutic effect of Gamma Knife radiosurgery [J]. Clin Neurol Neurosurg, 2014, 127: 59-64.
16
Bansal S, Suri A, Singh M, et al. Cavernous sinus hemangioma: a fourteen year single institution experience [J]. J Clin Neurosci, 2014, 21(6): 968-974.

URL    
17
Song SW, Kim DG, Chung HT, et al. Stereotactic radiosurgery for cavernous sinus hemangiomas [J]. J Neurooncol, 2014, 118(1): 163-168.
18
Park CK, Choi SK, Kang IH, et al. Radiosurgical considerations for cavernous sinus hemangioma: long-term clinical outcomes [J]. Acta Neurochir (Wien), 2016, 158(2): 313-318.
19
Wang Y, Li P, Zhang XJ, et al. Gamma Knife surgery for cavernous sinus hemanginoma: a report of 32 cases [J]. World Neurosurg, 2016, 94: 18-25.
20
Xu Q, Shen J, Feng Y, et al. Gamma Knife radiosurgery for the treatment of cavernous sinus hemangiomas [J]. Oncol Lett, 2016, 11(2): 1545-1548.
21
Goel A. The extradural approach to lesions involving the cavernous sinus [J]. Br J Neurosurg, 1997, 11(2): 134-138.
22
Wang X, Mei G, Liu X, et al. The role of stereotactic radiosurgery in cavernous sinus hemangiomas: a systematic review and meta-analysis [J]. J Neurooncol, 2012, 107(2): 239-245.
23
Wang EM, Pan L, Zhou LF, et al. Radiosurgery for cavernous sinus hemangiomas: medium- and long-term results [J]. Zhonghua Yi Xue Za Zhi, 2010, 90(47): 3327-3330.
24
Zhou LF, Mao Y, Chen L. Diagnosis and surgical treatment of cavernous sinus hemangiomas: an experience of 20 cases [J]. Surg Neurol, 2003, 60(1): 31-36, discussion 36-37.
25
Tang X, Wu H, Wang B, et al. A new classification and clinical results of Gamma Knife radiosurgery for cavernous sinus hemangiomas: a report of 53 cases [J]. Acta Neurochir (Wien), 2015, 157(6): 961-969, discussion 969.
26
Nakamura N, Shin M, Tago M, et al. Gamma knife radiosurgery for cavernous hemangiomas in the cavernous sinus. Report of three cases [J]. J Neurosurg, 2002, 97(5 Suppl): 477-480.
27
Li P, Ren H, Zhang S, et al. Clinical results of Gamma Knife surgery for cavernous sinus hemangiomas [J]. J Neurosurg, 2012, 117 Suppl: 89-95.

URL    
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