切换至 "中华医学电子期刊资源库"

中华脑血管病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 115 -119. doi: 10.11817/j.issn.1673-9248.2022.02.010

综述

肿瘤相关蛛网膜下腔出血的研究进展
陈仕检1, 梁志坚2,()   
  1. 1. 530021 广西南宁,广西医科大学第一附属医院神经内科;545005 广西柳州,广西医科大学第四附属医院神经内科
    2. 530021 广西南宁,广西医科大学第一附属医院神经内科
  • 收稿日期:2022-02-25 出版日期:2022-04-01
  • 通信作者: 梁志坚
  • 基金资助:
    国家重点研发计划(2018YFC1311305)

Progress in tumor-associated subarachnoid hemorrhage

Shijian Chen1, Zhijian Liang2,()   

  1. 1. Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Department of Neurology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China
    2. Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
  • Received:2022-02-25 Published:2022-04-01
  • Corresponding author: Zhijian Liang
引用本文:

陈仕检, 梁志坚. 肿瘤相关蛛网膜下腔出血的研究进展[J]. 中华脑血管病杂志(电子版), 2022, 16(02): 115-119.

Shijian Chen, Zhijian Liang. Progress in tumor-associated subarachnoid hemorrhage[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(02): 115-119.

肿瘤人群颅内出血的病因与一般人群不同,并因肿瘤的类型而异。临床和尸检研究发现,肿瘤引起的颅内出血,约占自发性颅内出血的0.9%~11.0%。其中,有文献报道蛛网膜下腔出血约占22%,其肿瘤类型主要以实体肿瘤、血液恶性肿瘤多见。迄今研究可发现肿瘤相关蛛网膜下腔出血可由瘤内出血、凝血障碍、癌性动脉瘤、机械创伤等多种因素引起。本文对肿瘤相关蛛网膜下腔出血进行论述,进一步阐释其发生、发展机制,以提高临床医师对该类疾病的认识,减少临床误诊、漏诊。

The etiology of intracranial hemorrhage in the patients with tumors is different from that in the general population and varies among patients with different types of tumors. Clinical and autopsy studies have found that intracranial hemorrhage caused by tumors, including subarachnoid hemorrhage, accounts for approximately 0.9% to 11% of spontaneous intracranial hemorrhage, among which subarachnoid hemorrhage accounts for 22%. They are mainly solid tumors and hematologic malignancies. Currently, studies have demonstrated that tumor-related subarachnoid hemorrhage can be caused by multiple factors such as intratumor hemorrhage, coagulation disorders, cancerous aneurysms, and mechanical trauma. In this review, tumor-related subarachnoid hemorrhage is discussed to clarify its occurrence and development mechanism, so as to improve clinicians' understanding of this disease and reduce clinical misdiagnosis and missed diagnosis.

1
Tan D, Daly C, Xenos C, et al. Glioblastoma presenting as spontaneous subarachnoid hemorrhage: technical case note of combined endovascular and microsurgical vision-sparing treatment [J]. World Neurosurg, 2019, 128: 426-430.
2
胡新明, 陈永键, 张学军, 等. 以蛛网膜下腔出血为首发症状的脑肿瘤3例 [J]. 中华神经医学杂志, 2003, 2(1): 79.
3
Kukreja S, Ambekar S, Sharma M, et al. Cauda equina schwannoma presenting with intratumoral hemorrhage and intracranial subarachnoid hemorrhage [J]. J Neurosurg Spine, 2014, 21(3): 357-360.
4
Spetzger U, Mull M, Sure U, et al. Subarachnoid and intraventricular hemorrhage caused by hypernephroma metastasis, accompanied by innocent bilateral posterior communicating artery aneurysms [J]. Surg Neurol, 1995, 44(3): 275-278.
5
Nagai S, Asai T, Watanabe T, et al. Simultaneous appearance of central nervous system relapse and subarachnoid hemorrhage during the treatment for acute promyelocytic leukemia [J]. Ann Hematol, 2008, 87(7): 593-595.
6
Hentschel S, Toyota B. Intracranial malignant glioma presenting as subarachnoid hemorrhage [J]. Can J Neurol Sci, 2003, 30(1): 63-66.
7
Nakau R, Kamiyama H, Kazumata K, et al. Subarachnoid hemorrhage associated with clival chordoma--case report [J]. Neurol Med Chir (Tokyo), 2003, 43(12): 605-607.
8
Van Gijn J, Van Dongen KJ, Vermeulen M, et al. Perimesencephalic hemorrhage: a nonaneurysmal and benign form of subarachnoid hemorrhage [J]. Neurology, 1985, 35(4): 493-497.
9
Stark AM, Buhl R, Hugo HH, et al. Chronic recurrent subarachnoid hemorrhage from a trigeminal nerve malignant peripheral nerve sheath tumor: case report [J]. Neurosurgery, 2006, 59(2): E425; discussion E425.
10
Steinbok P, Dolman CL, Kaan K. Pineocytomas presenting as subarachnoid hemorrhage. Report of two cases [J]. J Neurosurg, 1977, 47(5): 776-780.
11
Kirshbaum JD, Chapman BM. Subarachnoid hemorrhage secondary to a tumor of the hypophysis with acromegaly [J]. Ann Intern Med, 1948, 29(3): 536-540.
12
Matsumoto K, Akagi K, Abekura M, et al. Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage [J]. Neurol Med Chir (Tokyo), 1997, 37(11): 849-851.
13
Bosnjak R, Derham C, Popović M, et al. Spontaneous intracranial meningioma bleeding: clinicopathological features and outcome [J]. J Neurosurg, 2005, 103(3): 473-484.
14
Nutt SH, Patchell RA. Intracranial hemorrhage associated with primary and secondary tumors [J]. Neurosurg Clin N Am, 1992, 3(3): 591-599.
15
Ito Y, Araki Y, Izumi T, et al. Case of subarachnoid hemorrhage from ruptured oncotic fusiform aneurysms from choriocarcinoma metastasis treated with aneurysmectomy and vessel reconstruction [J]. World Neurosurg, 2018, 113: 98-102.
16
Mills B, Marks PV, Nixon JM. Spinal subarachnoid haemorrhage from an "ancient" schwannoma of the cervical spine [J]. Br J Neurosurg, 1993, 7(5): 557-559.
17
Graus F, Rogers LR, Posner JB. Cerebrovascular complications in patients with cancer [J]. Medicine (Baltimore), 1985, 64(1): 16-35.
18
Liwnicz BH, Wu SZ, Tew JM. The relationship between the capillary structure and hemorrhage in gliomas [J]. J Neurosurg, 1987, 66(4): 536-541.
19
Navi BB, Reichman JS, Berlin D, et al. Intracerebral and subarachnoid hemorrhage in patients with cancer [J]. Neurology, 2010, 74(6): 494-501.
20
Renoux C, Vahey S, Dell'Aniello S, et al. Association of selective serotonin reuptake inhibitors with the risk for spontaneous intracranial hemorrhage [J]. JAMA Neurol, 2017, 74(2): 173-180.
21
Qureshi AI, Malik AA, Saeed O, et al. Hormone replacement therapy and the risk of subarachnoid hemorrhage in postmenopausal women [J]. J Neurosurg, 2016, 124(1): 45-50.
22
Rim NJ, Kim HS, Kim SY. A "benign" sphenoid ridge meningioma manifesting as a subarachnoid hemorrhage associated with tumor invasion into the middle cerebral artery [J]. Korean J Radiol, 2008, 9 Suppl(Suppl): S10-S13.
23
Kotapka MJ, Kalia KK, Martinez AJ, et al. Infiltration of the carotid artery by cavernous sinus meningioma [J]. J Neurosurg, 1994, 81(2): 252-255.
24
Bruni P, Esposito S, Oddi G, et al. Subarachnoid hemorrhage from multiple neurofibromas of the cauda equina: case report [J]. Neurosurgery, 1991, 28(6): 910-913.
25
Shibahara I, Watanabe T, Ezura M, et al. Clinical features of subarachnoid hemorrhage in patients with positive cancer history [J]. J Neurooncol, 2016, 128(1): 129-136.
26
Grollmus J. Spinal subarachnoid hemorrhage with schwannoma [J]. Acta Neurochir (Wien), 1975, 31(3-4): 253-256.
27
Chalif DJ, Black K, Rosenstein D. Intradural spinal cord tumor presenting as a subarachnoid hemorrhage: magnetic resonance imaging diagnosis [J]. Neurosurgery, 1990, 27(4): 631-634.
28
Admiraal P, Hazenberg GJ, Algra PR, et al. Spinal subarachnoid hemorrhage due to a filum terminale ependymoma [J].Clin Neurol Neurosurg, 1992, 94(1): 69-72.
29
Nassar SI, Correll JW. Subarachnoid hemorrhage due to spinal cord tumors [J]. Neurology, 1968, 18(1 Pt 1): 87-94.
30
Hawkins CP, Heron JR. Subarachnoid hemorrhage from spinal tumor (in the absence of spinal symptoms or signs) [J]. J Neurol Neurosurg Psychiatry, 1988, 51(2): 305-307.
31
Halpern L, Feldman S, Peyser E. Subarachnoid hemorrhage with papilledema due to spinal neurofibroma [J]. AMA Arch Neurol Psychiatry, 1958, 79(2): 138-141.
32
Cummings TM, Johnson MH. Neurofibroma manifested by spinal subarachnoid hemorrhage [J]. AJR Am J Roentgenol, 1994, 162(4): 959-960.
33
Inci S, Bozkurt G, Gulsen S, et al. Rare cause of subarachnoid hemorrhage: spinal meningeal carcinomatosis. Case report [J]. J Neurosurg Spine, 2005, 2(1): 79-82.
34
Dijindjian M, Djindjian R, Houdart R, et al. Subarachnoid hemorrhage due to intraspinal tumors [J]. Surg Neurol, 1978, 9(4): 223-229.
35
Pau A, Orunesu G, Sehrbundt Viale E, et al. Mobile neurinoma of the cauda equina. Case report [J]. Acta Neurochir (Wien), 1982, 60(1-2): 115-117.
36
Lossos A, Siegal T. Spinal subarachnoid hemorrhage associated with leptomeningeal metastases [J]. J Neurooncol, 1992, 12(2): 167-171.
37
Franzoi MA, Hortobagyi GN. Leptomeningeal carcinomatosis in patients with breast cancer [J]. Crit Rev Oncol Hematol, 2019, 135: 85-94.
38
Wanarak W, Songkiet S. Intracerebral hemorrhage cause by a ruptured oncotic aneurysm from choriocarcinoma metastasis [J]. Asian J Neurosurg, 2013, 8(1): 48-50.
39
Omofoye OA, Barnett R, Lau W, et al. Neoplastic cerebral aneurysm from metastatic nonsmall cell lung carcinoma: case report and literature review [J]. Neurosurgery, 2018, 83(6): E221-E225.
40
Nayar G, Ejikeme T, Chongsathidkiet P, et al. Leptomeningeal disease: current diagnostic and therapeutic strategies [J]. Oncotarget, 2017, 8(42): 73312-73328.
41
Zairi F, De Saint Denis T, Thines L, et al. Ruptured cerebral oncotic aneurysm from choriocarcinoma: report of two cases and review of the literature [J]. Acta Neurochir (Wien), 2011, 153(2): 353-357.
42
Costigan DA, Winkelman MD. Intramedullary spinal cord metastasis. A clinicopathological study of 13 cases [J]. J Neurosurg, 1985, 62(2): 227-233.
43
Connolly ES, Winfree CJ, McCormick PC, et al. Intramedullary spinal cord metastasis: report of three cases and review of the literature [J]. Surg Neurol, 1996, 46(4): 329-337, discussion 337-338.
44
Ateaque A, Martin JL, O'Brien C, et al. Intramedullary spinal cord metastases from a hypernephroma 11 years following the diagnosis and treatment of the primary lesion [J]. Br J Neurosurg, 2000, 14(5): 474-476.
45
Grossman SA, Krabak MJ. Leptomeningeal carcinomatosis [J]. Cancer Treat Rev, 1999, 25(2): 103-119.
46
Groch SN, Sayre GP, Heck FJ. Cerebral hemorrhage in leukemia [J]. Arch Neurol, 1960, 2: 439-451.
47
Rahko PS, Nollet DJ, Blomberg DJ. Infiltration of a cerebral artery aneurysm by malignant lymphoma cells with acute rupture: report of a case [J]. Hum Pathol, 1980, 11(4): 396-398.
48
Papke K, Masur H, Martinez-Rubio A, et al. Complete bilateral oculomotor palsy: the only clinical sign of subarachnoid hemorrhage in leukemia [J]. Acta Neurol Scand, 1993, 88(2): 153-156.
49
Anda T, Haraguchi W, Miyazato H, et al. Ruptured distal middle cerebral artery aneurysm filled with tumor cells in a patient with intravascular large B-cell lymphoma [J]. J Neurosurg, 2008, 109(3): 492-496.
50
Vázquez E, Lucaya J, Castellote A, et al. Neuroimaging in pediatric leukemia and lymphoma: differential diagnosis [J]. Radiographics, 2002, 22(6): 1411-1428.
51
Chen CY, Tai CH, Cheng A, et al. Intracranial hemorrhage in adult patients with hematological malignancies [J]. BMC Med, 2012, 10: 97.
52
Glass J. Neurologic complications of lymphoma and leukemia [J]. Semin Oncol, 2006, 33(3): 342-347.
53
Alatoom A, Elsabrouty R, Willis J, et al. Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia [J]. Int J Clin Exp Pathol, 2009, 2(5): 498-507.
54
Seki A, Uchiyama H, Fukushi T, et al. Incidental findings of brain magnetic resonance imaging study in a pediatric cohort in Japan and recommendation for a model management protocol [J]. J Epidemiol, 2010, 20 Suppl 2(Suppl 2): S498-S504.
55
Chen S, Zhang J, Lu X, et al. cancer related subarachnoid hemorrhage: a multicenter retrospective study using propensity score matching analysis [J]. Front Cell Neurosci, 2022, 16(2): 813084.
[1] 韩丹, 王婷, 肖欢, 朱丽容, 陈镜宇, 唐毅. 超声造影与增强CT对儿童肝脏良恶性病变诊断价值的对比分析[J]. 中华医学超声杂志(电子版), 2023, 20(09): 939-944.
[2] 郏亚平, 曾书娥. 含鳞状细胞癌成分的乳腺化生性癌的超声与病理特征分析[J]. 中华医学超声杂志(电子版), 2023, 20(08): 844-848.
[3] 姚宏伟, 魏鹏宇, 高加勒, 张忠涛. 不断提高腹腔镜右半结肠癌D3根治术的规范化[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 1-4.
[4] 杜晓辉, 崔建新. 腹腔镜右半结肠癌D3根治术淋巴结清扫范围与策略[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 5-8.
[5] 周岩冰, 刘晓东. 腹腔镜右半结肠癌D3根治术消化道吻合重建方式的选择[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 9-13.
[6] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[7] 张生军, 赵阿静, 李守博, 郝祥宏, 刘敏丽. 高糖通过HGF/c-met通路促进结直肠癌侵袭和迁移的实验研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 21-24.
[8] 张焱辉, 张蛟, 朱志贤. 留置肛管在中低位直肠癌新辅助放化疗后腹腔镜TME术中的临床研究[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 25-28.
[9] 李凤仪, 李若凡, 高旭, 张超凡. 目标导向液体干预对老年胃肠道肿瘤患者术后血流动力学、胃肠功能恢复的影响[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 29-32.
[10] 李建美, 邓静娟, 杨倩. 两种术式联合治疗肝癌合并肝硬化门静脉高压的安全性及随访评价[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 41-44.
[11] 钱龙, 陆晓峰, 王行舟, 杜峻峰, 沈晓菲, 管文贤. 神经系统调控胃肠道肿瘤免疫应答研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 86-89.
[12] 曹长青, 郭新艳, 高源, 张存, 唐海利, 樊东, 杨小军, 张松, 赵华栋. 肿瘤微环境参与介导HER2阳性乳腺癌曲妥珠单抗耐药的研究进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 90-95.
[13] 燕速, 霍博文, 徐惠宁. 4K荧光腹腔镜扩大右半结肠CME+D3根治术及No.206、No.204组淋巴结清扫术[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 14-14.
[14] 徐军, 姬园园, 陈君平, 王健. 伴菊形团结构的脑膜瘤合并颅骨侵犯一例并文献复习[J]. 中华临床医师杂志(电子版), 2023, 17(08): 916-919.
[15] 王军, 刘鲲鹏, 姚兰, 张华, 魏越, 索利斌, 陈骏, 苗成利, 罗成华. 腹膜后肿瘤切除术中大量输血患者的麻醉管理特点与分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 844-849.
阅读次数
全文


摘要