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中华脑血管病杂志(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 225 -229. doi: 10.3877/cma.j.issn.1673-9248.2026.02.017

病例报告

反复误诊为脑梗死神经元核内包涵体病的病例报告
刘卫卫1, 郑丹枫2, 李会军1, 赵胜祥3, 王惠芳4,()   
  1. 1 102445 北京北亚骨科医院神经内科
    3 102445 北京北亚骨科医院放射科
    2 100191 北京大学第三医院病理科
    4 102206 北京大学国际医院神经内科
  • 收稿日期:2025-11-15 出版日期:2026-04-01
  • 通信作者: 王惠芳

Case report of neuronal intranuclear inclusion disease repeatedly misdiagnosed as cerebral infarction

Weiwei Liu, Danfeng Zheng, Huijun Li   

  • Received:2025-11-15 Published:2026-04-01
引用本文:

刘卫卫, 郑丹枫, 李会军, 赵胜祥, 王惠芳. 反复误诊为脑梗死神经元核内包涵体病的病例报告[J/OL]. 中华脑血管病杂志(电子版), 2026, 20(02): 225-229.

Weiwei Liu, Danfeng Zheng, Huijun Li. Case report of neuronal intranuclear inclusion disease repeatedly misdiagnosed as cerebral infarction[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2026, 20(02): 225-229.

图1 2016年1月患者头颅磁共振成像影像学资料。图a~g为弥散加权成像,提示皮髓交界区线样高信号
图2 2023年4月患者头颅磁共振成像和磁共振血管成像(MRA)影像学资料。图a~g为弥散加权成像,提示皮髓交界区及胼胝体周围飘带状高信号;图h、i为MRA,提示双侧大脑中动脉局限性狭窄
图3 2023年5月患者全脑数字减影血管造影(DSA)影像学资料。图a~c提示左侧大脑后动脉局限性狭窄
图4 2024年9月27日患者头颅磁共振成像影像学资料。图a~g为弥散加权成像,提示双侧额顶枕叶皮质下条索状高信号
图5 患者皮肤活检染色结果。图a为苏木精-伊红(HE)染色(×40),箭头为局泌汗腺细胞核内类圆形粉染包涵体;图b为P62免疫组化染色,箭头为局泌汗腺细胞核内类圆形P62阳性包涵体
表1 NIID和Binswanger病的鉴别要点
表2 NIID与CADASIL的鉴别要点
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