血压变异性与脑白质高信号的研究进展

doi:10.11817/j.issn.1673-9248.2021.04.012

血压变异性是指在各种病理、生理因素的影响下血压波动的程度。血管源性脑白质高信号（WMH）是指位于脑白质，病变范围大小不等的异常信号。高血压是WMH的主要危险因素之一，高血压患者更容易出现血压变异性增大，目前不少研究关注WMH与血压变异性的关系。本文对相关研究进行综述，从病理机制方面解释了高血压、血压变异性与WMH的内在关系，总结了不同的监测方式及降压药物对WMH发生发展的影响，以期建立合适的预测模型评估预后，并为早期干预WMH提供适当的降压策略。

关键词: 血压变异性, 脑白质高信号, 抗高血压药物

Blood pressure variability (BPV) refers to the degree of pressure fluctuations in the influence of various pathological and physiological factors. White matter hyperintensity (WMH) is an abnormal signal located in the white matter of the brain with varying lesion range. Hypertension is one of the main risk factors for WMH. Patients with hypertension are more likely to have increased blood pressure variability. At present, many studies focus on the relationship between WMH and blood pressure variability. This paper summarizes the related researches, explains the internal relationship between hypertension, BPV and WMH from the pathological mechanism, and the influence of different monitoring methods and antihypertensive medication on the occurrence and development of WMH, as to establish an appropriate prediction model to evaluate the prognosis and provide appropriate antihypertensive strategies for early intervention of WMH.

Key words: Blood pressure variability, White matter hyperintensity, Antihypertensive medication

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Advances in the relationship between blood pressure variability and white matter hyperintensity

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