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中华脑血管病杂志(电子版) ›› 2021, Vol. 15 ›› Issue (04) : 271 -273. doi: 10.11817/j.issn.1673-9248.2021.04.015

病例报告

抗LGI 1抗体介导的自身免疫性脑炎一例报道及文献复习
夏禹1,()   
  1. 1. 230022 合肥,安徽医科大学第一附属医院神经内科
  • 收稿日期:2020-12-06 出版日期:2021-08-09
  • 通信作者: 夏禹

Anti-LGI1 antibody mediated autoimmune encephalitis : a case report and literature review

Yu Xia1()   

  • Received:2020-12-06 Published:2021-08-09
  • Corresponding author: Yu Xia
引用本文:

夏禹. 抗LGI 1抗体介导的自身免疫性脑炎一例报道及文献复习[J]. 中华脑血管病杂志(电子版), 2021, 15(04): 271-273.

Yu Xia. Anti-LGI1 antibody mediated autoimmune encephalitis : a case report and literature review[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2021, 15(04): 271-273.

图1 脑电图显示以低中位9~10 c/s α波为基本节律,调幅尚可,两侧半球大致对称,视反应α波抑制完全,且过度换气试验中未见明显异常
图2 头颅MRI平扫提示T1-WI显示双侧海马低信号(图a、b),T2-WI显示双侧海马高信号(图c、d)
1
Li Z, Cui T, Shi W, et al. Clinical analysis of leucine-rich glioma inactivated-1 protein antibody associated with limbic encephalitis onset with seizures [J]. Medicine (Baltimore), 2016, 95(28): e4244.
2
Ernst L, David B, Gaubatz J, et al. Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis [J]. AJNR Am J Neuroradiol, 2019, 40(12): 2081-2089.
3
Budhram A, Leung A, Nicolle MW, et al. Diagnosing autoimmune limbic encephalitis [J]. CMAJ, 2019, 191(19): E529-E534.
4
Radja GK, Cavanna AE. Treatment of VGKC complex antibody-associated limbic encephalitis: a systematic review [J]. J Neuropsychiatry Clin Neurosci, 2013, 25(4): 264-271.
5
Malter MP, Frisch C, Schoene-Bake JC, et al. Outcome of limbic encephalitis with VGKC-complex antibodies: relation to antigenic specificity [J]. J Neurol, 2014, 261(9): 1695-1705.
6
Watanabe O. [Autoimmune Associated Encephalitis and Dementia] [J]. Brain Nerve, 2016, 68(4): 341-350.
7
Plantone D. Striatum Involvement in LGI1 Limbic Encephalitis [J]. Clin Psychopharmacol Neurosci, 2018, 16(4): 508-509.
8
Attademo L, De Falco S, Rosanova M, et al. A case report of limbic encephalitis in a metastatic colon cancer patient during first-line bevacizumab-combined chemotherapy [J]. Medicine (Baltimore), 2018, 97(9): e0011.
9
Bhandari B, Basyal B, Sendil S, et al. Atypical presentation of an elderly male with autoimmune encephalitis: anti-LG1 limbic encephalitis [J]. J Community Hosp Intern Med Perspect, 2020, 10(4): 377-379.
10
Debanne D, El Far O. Pre- and postsynaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis [J]. Brain, 2018, 141(11): 3092-3095.
11
Kelley BP, Patel SC, Marin HL, et al. Autoimmune encephalitis: pathophysiology and imaging review of an overlooked diagnosis [J]. AJNR Am J Neuroradiol, 2017, 38(6): 1070-1078.
12
关鸿志, 王佳伟. 中国自身免疫性脑炎诊治专家共识 [J]. 中华神经科杂志, 2017, 50(2): 91-98.
13
Dalmau J, Graus F, Villarejo A, et al. Clinical analysis of anti-Ma2-associated encephalitis [J]. Brain, 2004, 127(Pt 8): 1831-1844.
14
Erazo Torricelli R. [Autoimmune encephalitis. Anti-NMDA receptor and new immunophenotypes] [J]. Medicina (B Aires), 2019, 79 Suppl 3: 54-59.
15
van Vliet J, Meulstee J, Hartong EG, et al. [Autoimmune limbic encephalitis: importance of early diagnosis and treatment] [J]. Ned Tijdschr Geneeskd, 2012, 156(16): A4455.
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