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中华脑血管病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (04) : 307 -311. doi: 10.11817/j.issn.1673-9248.2023.04.001

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卵圆孔未闭相关血栓形成机制的研究进展
尹琛俊, 张喆, 李晓明()   
  1. 100191 北京,北京大学第三医院心脏外科
    100029 北京,首都医科大学附属北京安贞医院介入超声科
  • 收稿日期:2023-07-01 出版日期:2023-08-01
  • 通信作者: 李晓明
  • 基金资助:
    北京大学第三医院院临床重点项目(BYSYZD2022034)

Advance in mechanisms of patent foramen ovale-associated thrombosis

Chenjun Yin, Zhe Zhang, Xiaoming Li()   

  1. Department of Cardiac Surgery, Peking University Third Hospital, Beijing 100191, China
    Department of Interventional Ultrasound, Beijing anzhen hospital, Capital Medical University, Beijing 100029, China
  • Received:2023-07-01 Published:2023-08-01
  • Corresponding author: Xiaoming Li
引用本文:

尹琛俊, 张喆, 李晓明. 卵圆孔未闭相关血栓形成机制的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 307-311.

Chenjun Yin, Zhe Zhang, Xiaoming Li. Advance in mechanisms of patent foramen ovale-associated thrombosis[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(04): 307-311.

卵圆孔未闭(PFO)是指原发隔和继发隔未能完全融合而留有缝隙样结构,与以血栓形成、栓塞为基础的隐源性卒中和偏头痛等疾病密切相关。充分了解PFO相关血栓形成的机制将有助于临床识别病理性PFO及进行个体化管理,使患者充分获益。本文拟从反常栓塞、原位血栓形成、左心房功能改变及血液高凝状态等方面对PFO相关血栓形成机制的研究进展进行综述,以期为后续PFO相关疾病的高危因素及预防策略研究提供理论基础。

Patent foramen ovale (PFO) refers to the gap-like structure left after the septum primum and septum secundum failed to fully fuse, which is closely related to cryptogenic stroke and migraine based on thrombosis and embolism. Gaining a comprehensive understanding of the underlying mechanisms of PFO-associated thrombosis will greatly contribute to the clinical identification of the pathology of PFO and individualized management, benefiting patients fully. This article reviewed the research progress on PFO-related thrombosis mechanisms from paradoxical embolism, in situ thrombosis, left atrial function changes to hypercoagulable state, providing a theoretical basis for the following research on high-risk factors and prevention strategies of PFO-related diseases.

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