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中华脑血管病杂志(电子版)

中华脑血管病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 510 -517. doi: 10.11817/j.issn.1673-9248.2023.05.015

综述

菌群-肠道-脑轴与缺血性卒中危险因素关系的研究进展
金泽平, 董晶, 柳云鹏, 汪阳†()   
  1. 100020　首都医科大学附属北京朝阳医院神经外科
    100049　北京，清华大学玉泉医院（清华大学中西医结合医院）装备办
  • 收稿日期:2022-12-01 出版日期:2023-10-01
  • 通信作者: 汪阳
  • 基金资助:
    首都医科大学附属北京朝阳医院金种子基金资助项目(CYJZ202124)

Correlation between microbiota-gut-brain axis and the risk factors of ischemic stroke

Zeping Jin, Jing Dong, Yunpeng Liu, Yang Wang†()   

  1. Department of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Yuquan Hospital, Tsinghua University, Beijing 100049, China
  • Received:2022-12-01 Published:2023-10-01
  • Corresponding author: Yang Wang
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引用本文：

金泽平, 董晶, 柳云鹏, 汪阳. 菌群-肠道-脑轴与缺血性卒中危险因素关系的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 510-517.

Zeping Jin, Jing Dong, Yunpeng Liu, Yang Wang. Correlation between microbiota-gut-brain axis and the risk factors of ischemic stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 510-517.

缺血性卒中（IS）是目前全球最常见的神经系统疾病之一，其常见的危险因素为高血压、糖尿病、肥胖、衰老、血栓及粥样斑块形成等，这些危险因素可导致IS患者预后不佳。肠道菌群在近年来备受关注，着眼于菌群-肠道-脑轴的研究通过揭示肠道菌群、胃肠道及中枢神经系统之间的交互作用，从而发现肠道菌群与神经系统疾病的内在联系，最终可能揭示神经系统疾病发生发展的机制并寻求新的治疗潜在靶点。目前，越来越多的研究着眼于肠道菌群与IS相关危险因素之间的联系，发现菌群-肠道-脑轴在IS的发病过程中具有重要作用。本文就肠道菌群失调与IS相关危险因素之间的相互作用进行文献综述，以期为揭示IS发生发展的机制及寻找潜在的治疗方式提供更全面的视角及思路。

关键词: 菌群-肠道-脑轴, 缺血性卒中, 危险因素, 肠道菌群调节

Ischemic stroke (IS) is one of the most common neurological disease worldwide today. The risk factors of IS, such as hypertension, diabetes, obesity, aging, and formation of thrombus and atheromatous plaque, are demonstrated to be able to lead to poor prognosis of patients. The gut microbiota has attracted more attention in recent years, and the study focused on microbiota-gut-brain axis might help to reveal the mechanisms of the neurological and new therapeutic targets of IS. The microbiota-gut-brain axis describes the crosstalk between the gut microbiota, intestine, and center nervous system. At present, an increasingly number of studies have started to focus on the correlation between gut microbiota and risk factors of IS, indicating that the microbiota-gut-brain axis plays an important role in the pathogenesis of IS. This article reviews studies of how the gut microbiota alterations affect the progression of these risk factors, and how the onset of the risk factors would change the composition of gut microbiota. The primary purpose of the current study is to provide more comprehensive perspectives and collective ideas, in order to encourage more potential treatment for IS based on the microbiota-gut-brain axis.

Key words: Microbiota-gut-brain axis, Ischemic stroke, Risk factors, Gut microbiota modulation
图1 肠道菌群失调与IS危险因素的相互作用关系。IS相关危险因素，如高血压、糖尿病、心脏疾病、衰老以及吸烟，可改变肠道菌群组成导致肠道菌群失调，同时失调的肠道菌群可通过促使SCFA、TMAO升高或促进炎症反应等途径促进IS相关危险因素的发生发展 注：IS为缺血性卒中；SCFA为短链脂肪酸；TMAO为氧化三甲胺；IL-6为白介素-6；IL-13为白介素-13；TNF-α为肿瘤坏死因子-α；p65 NF-κB为人核转录因子-κB亚基p65
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