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中华脑血管病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 14 -18. doi: 10.11817/j.issn.1673-9248.2024.01.003

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血脂与轻度认知障碍相关性的研究进展
叶一1, 曾勇1,()   
  1. 1. 100029 首都医科大学附属北京安贞医院心内科
  • 收稿日期:2023-12-04 出版日期:2024-02-01
  • 通信作者: 曾勇
  • 基金资助:
    中华医学会心血管病学分会(CSC)临床研究专项基金(CSCF2023A03)

Research progress on the correlation between serum lipids and mild cognitive impairment

Yi Ye1, Yong Zeng1,()   

  1. 1. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
  • Received:2023-12-04 Published:2024-02-01
  • Corresponding author: Yong Zeng
引用本文:

叶一, 曾勇. 血脂与轻度认知障碍相关性的研究进展[J]. 中华脑血管病杂志(电子版), 2024, 18(01): 14-18.

Yi Ye, Yong Zeng. Research progress on the correlation between serum lipids and mild cognitive impairment[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(01): 14-18.

随着人口老龄化的发展,认知障碍已成为社会的沉重负担。脂质是中枢神经系统重要的组成部分,胆固醇是脂质成分的一种,人体中25%的胆固醇储存在大脑中。循环中血脂水平已被证明与心血管事件发生风险相关,临床中将极度降低低密度脂蛋白胆固醇(LDL-C)作为降脂目标。血液循环中各类血脂成分(总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)的变化与认知障碍存在相关性。脂质代谢相关基因的影响、27-羟基胆固醇的作用、高血脂水平对血脑屏障和脑组织的破坏均可影响认知功能。本文从血脂影响认知功能的相关机制、不同血脂成分和水平对认知功能的影响以及循环极低LDL-C对认知功能影响的临床试验等方面对血脂与认知功能的相关性进行文献综述。

Along with a growing aging population china, cognitive impairment has become a heavy burden on society. Lipids are an important part of the central nervous system. Cholesterol is a constituent of lipids and 25% of the body's cholesterol is stored in the brain. Circulating lipid levels have been shown to be associated with the risk of cardiovascular events, and extreme reduction of low-density lipoprotein cholesterol (LDL-C) is the clinical goal for lipid reduction. Changes in circulating blood lipid components (total cholesterol, triglycerides, low density lipoprotein cholesterol, high density lipoprotein cholesterol) are associated with cognitive impairment. The influence of lipid metabolism-related genes, the role of 27-hydroxycholesterol, and the disruption of blood-brain barrier and brain tissue by high lipid levels can affect cognitive function. This paper reviewed the literature on the correlation between lipid and cognitive function from multiple perspectives, including the related mechanisms of lipids affecting cognitive function, the impact of different lipid components and levels on cognitive function, and clinical trials of the effects of very low circulating LDL-C on cognitive function.

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