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中华脑血管病杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 19 -26. doi: 10.11817/j.issn.1673-9248.2024.01.004

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丁苯酞在各类型认知障碍治疗中的应用研究进展
赵晓晓1, 邱嘉婷1, 张懿姝1, 张蓉2, 张棚1, 刘晓蕾1,()   
  1. 1. 650032 昆明医科大学第一附属医院神经内科
    2. 650000 昆明市第二人民医院神经内科
  • 收稿日期:2023-04-11 出版日期:2024-02-01
  • 通信作者: 刘晓蕾
  • 基金资助:
    国家自然科学基金项目(82160272); 云南省科技厅科技计划项目(202101AT070151); 云南省卫生健康委员会医学学科带头人培养项目(D-2019013); 昆明医科大学科技创新团队建设项目(CXTD202104)

Application and prospect of Butylphthalide in the treatment of cognitive impairment

Xiaoxiao Zhao1, Jiating Qiu1, Yishu Zhang1, Rong Zhang2, Peng Zhang1, Xiaolei Liu1,()   

  1. 1. Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
    2. Department of Neurology, the Second People's Hospital of Kunming, Kunming 650000, China
  • Received:2023-04-11 Published:2024-02-01
  • Corresponding author: Xiaolei Liu
引用本文:

赵晓晓, 邱嘉婷, 张懿姝, 张蓉, 张棚, 刘晓蕾. 丁苯酞在各类型认知障碍治疗中的应用研究进展[J]. 中华脑血管病杂志(电子版), 2024, 18(01): 19-26.

Xiaoxiao Zhao, Jiating Qiu, Yishu Zhang, Rong Zhang, Peng Zhang, Xiaolei Liu. Application and prospect of Butylphthalide in the treatment of cognitive impairment[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(01): 19-26.

认知障碍是一种严重的、高级神经功能损伤综合征,给家庭及社会带来了沉重的负担。目前用于治疗认知障碍的药物种类较少且疗效有限,无法延缓或逆转疾病发展进程,寻求新的治疗策略迫在眉睫。近年的研究表明,丁苯酞(NBP)可用于治疗认知障碍,但其疗效性与安全性仍需进一步考证与探索。本文就NBP的药理机制、在认知障碍疾病研究中的应用等进行阐述,以期为认知功能障碍的临床治疗提供新的选择。

Cognitive impairment is a severe and advanced neurological detrimental syndrome that imposes a substantial burden on families and society. Few drugs can treat cognitive impairment, and their efficacy is limited. It is urgent to seek new treatment strategies. In recent years, studies have shown that dl-3-n-Butylphthalide can be used to treat cognitive impairment, while its efficacy and safety still need to be reinforced by more evidence. This review summarizes the pharmacological mechanism, basic researches and clinical studies of dl-3-n-Butylphthalide in cognitive disorders. This paper may provide a new option for treating cognitive conditions.

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