切换至 "中华医学电子期刊资源库"

中华脑血管病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (04) : 280 -283. doi: 10.3877/cma.j.issn.1673-9248.2025.04.003

指南与规范

《中国脑淀粉样血管病诊治共识(2023版)》解读及展望
倪俊(), 彭斌()   
  1. 100730 北京,中国医学科学院 北京协和医学院 北京协和医院神经科 疑难重症及罕见病国家重点实验室
  • 收稿日期:2025-03-14 出版日期:2025-08-01
  • 通信作者: 倪俊, 彭斌
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目(2024-I2M-C&T-B-007)

Interpretation and perspectives on the Chinese Consensus on the Diagnosis and Management of Cerebral Amyloid Angiopathy (2023 edition)

Jun Ni(), Bin Peng()   

  1. Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China
  • Received:2025-03-14 Published:2025-08-01
  • Corresponding author: Jun Ni, Bin Peng
引用本文:

倪俊, 彭斌. 《中国脑淀粉样血管病诊治共识(2023版)》解读及展望[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(04): 280-283.

Jun Ni, Bin Peng. Interpretation and perspectives on the Chinese Consensus on the Diagnosis and Management of Cerebral Amyloid Angiopathy (2023 edition)[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2025, 19(04): 280-283.

脑淀粉样血管病(CAA)被定义为β淀粉样蛋白沉积于软脑膜、皮质及小脑的小动脉、微动脉及毛细血管管壁所致的一类年龄相关脑小血管病,是老年人自发性脑叶出血的第一位原因,也是年龄相关认知下降的重要病因。基于病理、临床及影像学的Boston诊断标准,已经广泛应用于临床实践和研究。然而,国内研究者对CAA的认识存在不足,现有的CAA诊断标准对于临床工作的实际指导作用尚不能满足临床实践需求,且国内目前尚无针对CAA诊断、预防和治疗的指南及共识,故中华医学会神经病学分会及其脑血管病学组组织专家制订了《中国脑淀粉样血管病诊治共识(2023版)》(简称《共识》)。该《共识》采用国际公认的制定标准方法和流程,系统检索国内外最新文献证据,针对CAA诊断和治疗的14个临床问题给出了推荐意见,为中国神经科医师诊断和治疗CAA提供参考和指导。本文围绕该《共识》的主要推荐内容进行解读,以便读者更好地理解和掌握《共识》的相关内容。

Cerebral amyloid angiopathy (CAA) is an age-related cerebral small vessel disease characterized by the deposition of β-amyloid in the walls of small arteries, arterioles, and capillaries within the leptomeninges, cortex, and cerebellum. It is the leading cause of spontaneous lobar intracerebral hemorrhage in the elderly and a major etiological factor in age-related cognitive decline. The current diagnostic standard, the Boston criteria, integrates pathological, clinical, and neuroimaging features and is widely used in both clinical and research settings. However, awareness of CAA remains suboptimal in China, and existing diagnostic criteria do not fully align with the needs of routine clinical practice. Additionally, there has been a lack of nationwide guidelines or expert consensus on the diagnosis, prevention, and treatment of CAA in China. To bridge this gap, the Chinese Society of Neurology and its Cerebrovascular Disease Study Group convened a panel of experts to develop the Chinese Consensus on the Diagnosis and Management of Cerebral Amyloid Angiopathy (2023 edition) (hereinafter referred to as the Consensus). Adhering to internationally recognized methodological standards, the Consensus systematically reviewed the latest global evidence and provided evidence-based recommendations addressing 14 key clinical issues in CAA diagnosis and management. These recommendations aim to standardize clinical practice and serve as a practical guide for Chinese neurologists. This article delves into the Consensus's core recommendations to enhance their comprehension and clinical implementation.

1
吴娟娟, 倪俊. 脑淀粉样血管病发病机制的研究进展 [J]. 中国卒中杂志, 2021, 16(12): 1278-1283.
2
Viswanathan A, Greenberg SM. Cerebral amyloid angiopathy in the elderly [J]. Ann Neurol, 2011, 70(6): 871-880.
3
Charidimou A, Gang Q, Werring DJ. Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum [J]. J Neurol Neurosurg Psychiatry, 2012, 83(2): 124-137.
4
Jäkel L, De Kort A, Klijn K, et al. Prevalence of sporadic cerebral amyloid angiopathy: a systematic review and meta-analysis [J]. Alzheimers Dement, 2022, 18(1): 10-28.
5
Charidimou A, Boulouis G, Frosch MP, et al. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study [J]. Lancet Neurol, 2022, 21(8): 714-725.
6
Linn J, Halpin A, Demaerel P, et al. Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy [J]. Neurology, 2010, 74(17): 1346-1350.
7
中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国脑淀粉样血管病诊治共识(2023版)[J]. 中华神经科杂志, 2024, 57(10): 1051-1074.
8
Rannikmäe K, Samarasekera N, Martînez-Gonzâlez NA, et al. Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis [J]. J Neurol Neurosurg Psychiatry, 2013, 84(8): 901-908.
9
Theodorou A, Palaiodimou L, Malhotra K, et al. Clinical, neuroimaging, and genetic markers in cerebral amyloid angiopathy-related inflammation: a systematic review and meta-analysis [J]. Stroke, 2023, 54(1): 178-188.
10
Rodrigues MA, Samarasekera N, Lerpiniere C, et al. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study [J]. Lancet Neurol, 2018, 17(3): 232-240.
11
McCarron MO, Nicoll JA, Ironside JW, et al. Cerebral amyloid angiopathy-related hemorrhage. Interaction of APOE epsilon2 with putative clinical risk factors [J]. Stroke, 1999, 30(8): 1643-1646.
12
Wu J, Liu Z, Yao M, et al. Clinical characteristics of cerebral amyloid angiopathy and risk factors of cerebral amyloid angiopathy related intracerebral hemorrhage [J]. J Neurol, 2024, 271(8): 5025-5034.
13
Chung KK, Anderson NE, Hutchinson D, et al. Cerebral amyloid angiopathy related inflammation: three case reports and a review [J]. J Neurol Neurosurg Psychiatry, 2011, 82(1): 20-26.
14
Auriel E, Charidimou A, Gurol ME, et al. Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation [J]. JAMA Neurol, 2016, 73(2): 197-202.
15
Pradilla G, Ratcliff JJ, Hall AJ, et al. Trial of early minimally invasive removal of intracerebral hemorrhage [J]. N Engl J Med, 2024, 390(14): 1277-1289.
16
Fung C, Murek M, Z'Graggen WJ, et al. Decompressive hemicraniectomy in patients with supratentorial intracerebral hemorrhage [J]. Stroke, 2012, 43(12): 3207-3211.
17
Schelle J, Wegenast-Braun BM, Fritschi SK, et al. Early Aβ reduction prevents progression of cerebral amyloid angiopathy [J]. Ann Neurol, 2019, 86(4): 561-571.
18
Leurent C, Goodman JA, Zhang Y, et al. Immunotherapy with ponezumab for probable cerebral amyloid angiopathy [J]. Ann Clin Transl Neurol, 2019, 6(4): 795-806.
19
Voigt S, Koemans EA, Rasing I, et al. Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial [J]. Trials, 2023, 24(1): 378.
20
Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, et al. Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways [J]. Nat Rev Neurol, 2020, 16(1): 30-42.
21
Greenberg SM, Cordonnier C, Schneider JA, et al. Off-label use of aducanumab for cerebral amyloid angiopathy [J]. Lancet Neurol, 2021, 20(8): 596-597.
22
Arima H, Tzourio C, Anderson C, et al. Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial [J]. Stroke, 2010, 41(2): 394-396.
23
Xu J, Su Y, Sha Y, et al. Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification [J]. Alzheimers Dement, 2025, 21(3): e70044.
24
Leitner D, Kavanagh T, Kanshin E, et al. Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment [J]. Acta Neuropathol, 2024, 148(1): 9.
[1] 刘畅, 蒋洁, 胥雪冬, 崔立刚, 张睿超, 王淑敏, 陈文. 甲状腺规范化扫查及C-TIRADS 分类在二级和一级医疗机构的推广应用[J/OL]. 中华医学超声杂志(电子版), 2025, 22(05): 402-407.
[2] 王彦, 张晓航, 冉素真, 钟春燕, 张晋炜, 王希. 双胎贫血-红细胞增多序列征的产前超声特征分析[J/OL]. 中华医学超声杂志(电子版), 2025, 22(05): 462-469.
[3] 高加勒, 张忠涛. 结直肠癌外科领域最新进展与热点[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 595-599.
[4] 钱龙, 蔡大明, 王行舟, 艾世超, 胡琼源, 孙锋, 宋鹏, 王峰, 王萌, 陆晓峰, 朱欢欢, 沈晓菲, 管文贤. 局部不可切除胃癌转化治疗(联合免疫治疗)后淋巴结转移的相关危险因素分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 624-627.
[5] 薛兆强, 袁寅. 双镜联合保功能胃癌根治术治疗早期近端胃癌的临床研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 628-632.
[6] 王思竣, 王琼, 李珂雨, 袁新普, 张硕珉, 马睿, 谢天宇, 张朝军. 胃上部癌新辅助化疗联合免疫治疗后实施近端胃切除术的临床疗效分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(06): 637-641.
[7] 杨志, 夏雪峰, 管文贤. DeepSurv深度学习模型辅助胃癌术后精准化疗策略研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(05): 501-505.
[8] 林水荣, 宋子敏, 于玺, 李绍强, 华赟鹏, 沈顺利. 术前抗病毒治疗对HBV相关肝癌肝切除术后肝衰竭影响[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 700-706.
[9] 胡铭语, 李敬东, 肖雨竹, 黄杰. 初始不可切除肝癌患者转化治疗序贯手术的临床疗效分析[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 754-760.
[10] 张广权, 洪生杰, 陈显育, 王继才, 翟航, 吴芬芳, 史宪杰. 生物信息学分析内质网应激相关基因在非酒精性脂肪性肝炎发病中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 761-769.
[11] 杨金通, 付必莽, 马朝宇, 兰楮, 王朝, 李春满. 肝细胞癌伴淋巴结转移一例[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 770-774.
[12] 丁雪吟, 孙居仙, 石洁, 程树群. 肝癌肺转移的放射治疗研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 789-794.
[13] 黄超, 张佳茂, 孔艺洁, 刘玙寒, 苏彤, 方路, 梁博, 郑文娟. 组织病理分型在壶腹周围癌化疗方案制定中作用的文献综述[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 795-801.
[14] 袁洳靖, 孙居仙, 程树群. 肝癌合并门静脉癌栓放射治疗[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 659-666.
[15] 慕佳霖, 孙萌, 李育霖, 邹卉. 甲基丙二酸血症合并肾脏并发症的发生机制和治疗研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(05): 382-387.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?