The effect of urinary kallidinogenase on SDF-1, ET-1, VEGF, cognitive function in patients with acute cerebral infarction

doi:10.11817/j.issn.1673-9248.2020.04.006

Abstract

Abstract:

Objective

To investigate the effect of urinary kallidinogenase on stromal cell-derived factor-1 (SDF-1), vascular endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) and cognitive function in patients with acute cerebral infarction.

Methods

Sixty patients with acute cerebral infarction hospitalized in Xuzhou Central Hospital from January 2017 to May 2018 were randomly enrolled in control group and treatment group, 30 cases in each group. The control group received routine neurological medicine for acute cerebral infarction, and the treatment group received additional use of urinary kallidinogenase 0.15 PNA for injection. The course of treatment is 14 days. The concentration of SDF-1, ET-1, VEGF and MoCA score were measured before treatment and 14 days after treatment. The MoCA score was evaluated again 3 months after treatment.

Results

There were no significant differences in concentration of SDF-1, ET-1, VEGF, and MoCA scores between the two groups. After 14 days of treatment, the concentration of ET-1 in the treatment group[(57.33±14.61) pg/L] was significantly lower than that in the control group[(65.17±12.88) pg/L, P=0.031]. SDF-1[(4024.10±379.30) pg/ml], VEGF[(316.38±84.27) ng/ml] in the treatment group were significantly higher than SDF-1[(3171.60±337.00) pg/ml, P<0.001], VEGF[(250.26±93.56) ng/ml, P=0.006] in the control group three months after treatment, the MoCA score (26.60±1.75) was significantly higher than the control group(25.07±3.60, P=0.040).

Conclusion

Urinary kallidinogenase reduced the concentration of ET-1 in patients with acute cerebral infarction and increased the level of SDF-1 and VEGF, and possibly improving the cognitive function of patients with acute cerebral infarction.

Key words: Urinary kallidinogenase, Stromal cell-derived factor-1, Endothelin-1, Vascular endothelial growth factor, Cognitive function

Chunying Ou, Chuanling Li, Jing Guo, Xiaobin Li, Xiaolei An, Ke Xu. The effect of urinary kallidinogenase on SDF-1, ET-1, VEGF, cognitive function in patients with acute cerebral infarction[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(04): 217-220.

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Figures/Tables 2

组别	例数	男/女（例）	年龄（岁， $x ˉ ± s$ ）	受教育年限（年， $x ˉ ± s$ ）	收缩压（mmHg， $x ˉ ± s$ ）	舒张压（mmHg， $x ˉ ± s$ ）	糖化血红蛋白（%， $x ˉ ± s$ ）	MoCA评分（分， $x ˉ ± s$ ）
对照组	30	17/13	64.20±7.50	9.23±3.85	127.53±12.55	77.13±5.10	5.72±0.63	27.06±1.60
治疗组	30	16/14	61.27±8.87	9.00±4.64	130.67±11.03	77.23±5.70	6.00±0.53	27.13±1.33
统计值		χ²=0.067	t=-1.383	t=0.217	t=-1.027	t=-0.072	t=-1.891	t=0.031
P值		0.795	0.586	0.227	0.421	0.146	0.315	0.861

组别	例数	男/女（例）	年龄（岁， $x ˉ ± s$ ）	受教育年限（年， $x ˉ ± s$ ）	收缩压（mmHg， $x ˉ ± s$ ）	舒张压（mmHg， $x ˉ ± s$ ）	糖化血红蛋白（%， $x ˉ ± s$ ）	MoCA评分（分， $x ˉ ± s$ ）
对照组	30	17/13	64.20±7.50	9.23±3.85	127.53±12.55	77.13±5.10	5.72±0.63	27.06±1.60
治疗组	30	16/14	61.27±8.87	9.00±4.64	130.67±11.03	77.23±5.70	6.00±0.53	27.13±1.33
统计值		χ²=0.067	t=-1.383	t=0.217	t=-1.027	t=-0.072	t=-1.891	t=0.031
P值		0.795	0.586	0.227	0.421	0.146	0.315	0.861

组别	例数	SDF-1（pg/ml）		ET-1(pg/L)		VEGF（ng/ml）
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	30	2258.41±281.95	3171.60±337.00	79.90±17.53	65.17±12.88	206.51±75.11	250.26±93.56
治疗组	30	2278.68±265.44	4024.10±379.30	83.82±13.51	57.33±14.61	223.92±72.40	316.38±84.27
t值		0.082	84.693	0.944	4.865	2.445	8.272
P值		0.775	＜0.001	0.335	0.031	0.123	0.006

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