The safety and efficacy of stereotactic radiosurgery for cavernous sinus hemangioma

doi:10.11817/j.issn.1673-9248.2020.06.005

Abstract

Abstract:

Objective

To perform a systematic review and meta-analysis for exploring the safety and efficacy of stereotactic radiosurgery for cavernous sinus hemangioma.

Methods

Fifteen studies were identified through a literature search and the information of 155 patients was recorded. Clinical outcomes and the tumor response were the primary measurements of interest. The mean tumor volume was 14.7 cm³. Twenty-two patients (14.2%) were asymptomatic and 133 (85.8%) were symptomatic. Thirty-nine (35.8%) patients had cranial nerve III palsy while 31 (28.4%) patients and 28 (25.7%) patients had VI and II cranial nerve palsy, respectively.

Results

Among the 133 patients with symptoms, symptoms of 20 (15.3%) patients disappeared while 97 (74.0%) of them improved after the treatment. The symptoms of the remaining patients (10.79%, 14/131) were stable. The imaging results showed that there were 9 patients with tumor disappearance, 101 patients with significant reduction of tumor volume, 27 patients with partially reduced tumor volume and 13 patients without change. No adverse effects were observed in these patients except two patients. The improvement of symptom is not related to the volume or isodose (P＞0.05). The shrunk of volume is not related to the volume or isodose (P＞0.05). The improvement of symptoms of patients was better for patients with radiosurgery alone than the patients received surgery before radiosurgery (96.8% vs 69.4%, χ²=15.367, P＜0.001).

Conclusion

The meta-analysis indicated the stereotactic radiosurgery could be the optimal treatment therapy for cavernous sinus hemangioma.

Key words: Cavernous sinus hemangioma, Stereotactic radiosurgery, Efficacy, Safety

Zhenwei Sun, Yuefei Fan, Chao Han, Zhiping Dun. The safety and efficacy of stereotactic radiosurgery for cavernous sinus hemangioma[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(06): 341-345.

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References 27

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文献	病例数	年龄（岁）		肿瘤体积（cm³）		随访时间（月）		边缘剂量（Gy）		体积缩小率（%）
文献	病例数	平均	范围	平均	范围	平均	范围	平均	范围	平均	范围
Kida等^[6]	3	51.3	38~66	5.3	1.5~11.1	27	12~36	15.7	14~17	56.7	54~59
Seo等^[7]	1	79	79	8.5	8.5	24	24	15	15	100	100
Thompson等^[8]	3	27.3	14~44	4.5	2.8~5.6	12	6~18	16	14~19	56.3	0~86
Peker等^[9]	5	43.8	37~60	5.0	3.8~6.2	32.8	6~52	15	14~16	68.2	61~79
Ivanov等^[10]	3	52.7	38~67	12.7	6.4~19	12	12	11.7	10~13	60	45~75
Khan等^[11]	7	37.9	14~56	6.4	2.5~10.8	75.3	40~111	14.8	12.5~19.0	66.8	0~100
Chou等^[12]	7	43.7	26~77	9.9	3~23.1	50.7	6~156	12.5	12.5	81.6	56~100
Yamamoto等^[13]	30	53.3	19~78	11.5	1.5~51.4	53.2	12~138	13.5	8~17	-	-
Murphy^[14]	1	15	15	1.5	1.5	16	16	16	16	100	100
Anqi等^[15]	15	40.4	20~77	29.3	8~138	9.5	2~27	13.4	10~16	41.4	0~83.5
Bansal等^[16]	9	43	27~50	6.4	2.3~13.3	17	6~35	16.9	12~22.3	-	-
Song等^[17]	19	52.3	35~73	6.1	0.3~32.3	28.4	6~84	14.4	11.5~16	73.9	48~100
Park等^[18]	13	62.3	44~76	2.7	1.3~8.0	90	16~164	12.9	12~14	63	6~92
Wang等^[19]	32	49.1	21~73	30.5	2.5~78.6	30.3	12~67	14.5	11~16	74.4	11.6~100
Xu等^[20]	7	51.6	39~64	12.5	3.8~33.2	20.3	6~40	13.6	10~15	76.0	43.8~92.5

文献	病例数	年龄（岁）		肿瘤体积（cm³）		随访时间（月）		边缘剂量（Gy）		体积缩小率（%）
文献	病例数	平均	范围	平均	范围	平均	范围	平均	范围	平均	范围
Kida等^[6]	3	51.3	38~66	5.3	1.5~11.1	27	12~36	15.7	14~17	56.7	54~59
Seo等^[7]	1	79	79	8.5	8.5	24	24	15	15	100	100
Thompson等^[8]	3	27.3	14~44	4.5	2.8~5.6	12	6~18	16	14~19	56.3	0~86
Peker等^[9]	5	43.8	37~60	5.0	3.8~6.2	32.8	6~52	15	14~16	68.2	61~79
Ivanov等^[10]	3	52.7	38~67	12.7	6.4~19	12	12	11.7	10~13	60	45~75
Khan等^[11]	7	37.9	14~56	6.4	2.5~10.8	75.3	40~111	14.8	12.5~19.0	66.8	0~100
Chou等^[12]	7	43.7	26~77	9.9	3~23.1	50.7	6~156	12.5	12.5	81.6	56~100
Yamamoto等^[13]	30	53.3	19~78	11.5	1.5~51.4	53.2	12~138	13.5	8~17	-	-
Murphy^[14]	1	15	15	1.5	1.5	16	16	16	16	100	100
Anqi等^[15]	15	40.4	20~77	29.3	8~138	9.5	2~27	13.4	10~16	41.4	0~83.5
Bansal等^[16]	9	43	27~50	6.4	2.3~13.3	17	6~35	16.9	12~22.3	-	-
Song等^[17]	19	52.3	35~73	6.1	0.3~32.3	28.4	6~84	14.4	11.5~16	73.9	48~100
Park等^[18]	13	62.3	44~76	2.7	1.3~8.0	90	16~164	12.9	12~14	63	6~92
Wang等^[19]	32	49.1	21~73	30.5	2.5~78.6	30.3	12~67	14.5	11~16	74.4	11.6~100
Xu等^[20]	7	51.6	39~64	12.5	3.8~33.2	20.3	6~40	13.6	10~15	76.0	43.8~92.5

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