To explore the short and medium-term efficacy and influencing factors of simple flow diverter stents (FD) or combined with coil embolization in treating unruptured intracranial aneurysms.

The clinical data and 3-18 months of follow-up data of patients were collected and analyzed, who were treated with Tubridge (TB, Microport, Shanghai, CN) for intracranial aneurysm at the First Affiliated Hospital of Shenzhen University from January 2019 to December 2020. The clinical data, surgical outcomes (occlusion rate), and morphological characteristics of aneurysms were analyzed. For the above data, the influencing factors of occlusion rate were analyzed by univariate combined with multivariate unconditional logistic regression analysis.

A total of 46 cases with complete data were included in the study. According to the follow-up results, they were divided into the completed occlusion group (n=28) and the incomplete occlusion group (n=18). There were no statistically significant differences in ages of onset, aneurysm types, with or without collateral vessels (all P＞0.05). Among all patients, 32 patients were embolized with blood flow guidance device alone and the other 14 patients were assisted with coil embolization. The success rate of the operation was 100%. During postoperative imaging follow-up for 3-18 months, treatment with FD combined with coil embolization accounted for 12/28 in the completed occlusion group, and accounted for 2/18 in the incomplete occlusion group, showing a significantly statistical difference (χ²=4.792, P=0.029). Further comparative analysis showed that the presence or absence of collateral branches, with or without coil embolization, and follow-up time ＞6 months were the major factors affecting the primary closure of aneurysms (OR=0.101, 9.832, 9.266; P=0.003, 0.009, 0.021).

The occlusion rate of unruptured intracranial aneurysms treated with FDs was reasonable during the follow-up of more than 6 months, and the occlusion rate is higher when combined with coil embolization; however, the occlusion rate of aneurysms will be affected when there are collateral vessels.