Advance in the relationship between TLR4 signaling pathway and nervous system diseases

doi:10.11817/j.issn.1673-9248.2023.01.012

Abstract

Abstract:

Toll-like receptor 4 (TLR4), as a kind of pattern recognition receptor, is the key trigger of innate immune inflammatory response. Studies have confirmed that TLR4 signaling pathway-mediated immune inflammatory response plays a key role in stroke, Alzheimer's disease, Parkinson's disease, and other neurological diseases. This article mainly reviews the research progress of TLR4 signaling pathway in nervous system diseases, so as to inspire new ideas for TLR4-targeted therapy for nervous system diseases.

Key words: Toll-like receptor 4, Nervous system diseases, Inflammatory response

Haijie Gao, Baojun Wang. Advance in the relationship between TLR4 signaling pathway and nervous system diseases[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(01): 61-65.

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References 47

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