Research progress on the correlation between serum lipids and mild cognitive impairment

doi:10.11817/j.issn.1673-9248.2024.01.003

Abstract

Abstract:

Along with a growing aging population china, cognitive impairment has become a heavy burden on society. Lipids are an important part of the central nervous system. Cholesterol is a constituent of lipids and 25% of the body's cholesterol is stored in the brain. Circulating lipid levels have been shown to be associated with the risk of cardiovascular events, and extreme reduction of low-density lipoprotein cholesterol (LDL-C) is the clinical goal for lipid reduction. Changes in circulating blood lipid components (total cholesterol, triglycerides, low density lipoprotein cholesterol, high density lipoprotein cholesterol) are associated with cognitive impairment. The influence of lipid metabolism-related genes, the role of 27-hydroxycholesterol, and the disruption of blood-brain barrier and brain tissue by high lipid levels can affect cognitive function. This paper reviewed the literature on the correlation between lipid and cognitive function from multiple perspectives, including the related mechanisms of lipids affecting cognitive function, the impact of different lipid components and levels on cognitive function, and clinical trials of the effects of very low circulating LDL-C on cognitive function.

Key words: Serum lipids, Mild cognitive impairment, Correlation

Yi Ye, Yong Zeng. Research progress on the correlation between serum lipids and mild cognitive impairment[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(01): 14-18.

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