Research progress on the transcriptional regulation mechanisms of endogenous interleukin-2

doi:10.11817/j.issn.1673-9248.2024.06.011

Abstract

Abstract:

Interleukin-2 （IL-2）， the first successfully cloned cytokine derived from multicellular sources， is a multifunctional molecule primarily produced by CD4⁺ T cells.It plays a crucial regulatory role in multiple lymphocyte lineages， making it a promising therapeutic option for immune-mediated diseases.The transcriptional regulation of endogenous IL-2 involves various cis-acting elements and trans-acting factors，with the IL-2 gene promoter playing a vital role.This paper reviews the latest developments in engineered IL-2 research， and explores the molecular mechanisms regulating IL-2 transcription.It covers the expression distribution， expression patterns， epigenetic modifications of the IL-2 gene， and the diverse trans-acting factors that interact with its promoter.These insights are vital for optimizing IL-2-based therapeutic strategies and developing novel immunotherapies with higher target cell selectivity， extended half-life， enhanced stability， minimized side effects and immunogenicity， and expanded therapeutic applications.

Key words: Interleukin-2, Cis-acting elements, Trans-acting factors, Transcriptional regulation

Yiwei Zhang, Haiping Zhao. Research progress on the transcriptional regulation mechanisms of endogenous interleukin-2[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(06): 595-600.

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