Research progress on mechanism of urinary dysfunction in cerebral small-vessel disease

doi:10.11817/j.issn.1673-9248.2024.06.013

Abstract

Abstract:

Previous studies have posited that bladder function is highly dependent on the central nervous system， with the concept of the "vascular-brain-bladder axis" being widely applied to explain neurogenic urinary disorders.Cerebral small vessel disease （CSVD） represents a substantial health challenge in the elderly， with urinary dysfunction as one of its primary non-cognitive motor symptoms.These symptoms manifest diversely as urinary frequency， urgency， nocturia， and urge incontinence.The specific mechanisms underlying CSVD-related urinary dysfunction remain unclear.Recent research has identified a strong correlation between heart rate variability—a marker of autonomic function—and CSVD-related urinary dysfunction.Additionally， multiple studies have demonstrated that traditional imaging characteristics are also associated with these urinary symptoms.This paper aims to summarize the neural control and graded regulation of the micturition reflex， review the latest advancements in traditional imaging characteristics of CSVD，and propose potential neural mechanisms explaining CSVD-induced urinary dysfunction， with the goal of enhancing clinical physicians' comprehensive understanding and recognition of CSVD-related urinary issues.

Key words: Cerebral small-vessel disease, Urinary dysfunction, Autonomic nervous dysfunction, Imageology

Yuwei Wang, Qiong Yang, Wenhua Ding, Jingjing Qiu, Yurong Geng. Research progress on mechanism of urinary dysfunction in cerebral small-vessel disease[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(06): 606-610.

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