Brain-heart comorbidity diseases refer to the coexistence of pathological damage affecting the brain and the heart, characterized by high incidence, disability, and mortality rates. There is a significant comorbidity between cerebral and cardiovascular diseases, with approximately 37% of stroke patients concurrently suffering from ischemic heart disease, while cardiovascular diseases similarly increase the risk of cerebrovascular events. Patients with brain-heart comorbidity often experience motor dysfunction and autonomic nervous system dysregulation, predisposing them to secondary cardiopulmonary decline and ​further complicating rehabilitation. Cardiac rehabilitation (CR) improves cardiopulmonary fitness, exercise tolerance, and quality of life through comprehensive interventions including exercise training combined with psychological support. However, its application in brain-heart comorbidity diseases still face several challenges, including assessment methods, insufficient personalization of protocols, and poor patient adherence. This article reviews the epidemiology and pathological mechanisms of brain-heart comorbidity diseases, as well as advances in rehabilitation effectiveness based on multidimensional assessments and personalized interventions. Future research priorities include exploring innovative models such as telerehabilitation platforms and stratified management to optimize rehabilitation efficacy and enhance patient engagement.