Application of a novel Chinese intrasaccular flow disruption device in the treatment of wide-necked bifurcation aneurysms of the middle cerebral artery

doi:10.3877/cma.j.issn.1673-9248.2026.05.004

Abstract

Abstract:

Objective

To investigate the efficacy and safety of the Chinese Tulip intrasaccular flow disruption device in the treatment of wide-necked bifurcation aneurysms of the middle cerebral artery (MCA).

Methods

A total of 43 consecutive patients with saccular MCA bifurcation aneurysms were prospectively enrolled from eight medical centers in China between March and November 2023 and completed the full follow-up protocol. Among the 43 aneurysms, 40 were classified as wide-necked. All patients underwent endovascular treatment with the Tulip device. The technical success rate, degree of aneurysm occlusion (Raymond-Roy classification), neurological functional outcomes [modified Rankin scale (mRS)], and perioperative complications were recorded. Digital subtraction angiography follow-up was completed at 12 months post-procedure.

Results

The technical success rate was 100.00% (43/43), with a total of 44 Tulip devices successfully implanted. At the 12-month follow-up, the complete occlusion rate was 44.19% (19/43) and the adequate occlusion rate was 95.35% (41/43), and the mRS scores were 0 in 40 patients, 1 in 2 patients, and 2 in 1 patient. There were no intraoperative adverse events, and a total of 3 postoperative events including transient ischemic attack and thrombosis occurred.

Conclusion

The Tulip device is easy to use in the treatment of wide-necked MCA bifurcation aneurysms. Short-term follow-up reveals satisfactory occlusion rates and a low complication rate.

Key words: Middle cerebral artery, Wide-necked aneurysm, Intrasaccular flow disruption device, Cerebrovascular diseases, Clinical efficacy

Weiliang Jin, Fujunhui Zhang, Yisen Zhang. Application of a novel Chinese intrasaccular flow disruption device in the treatment of wide-necked bifurcation aneurysms of the middle cerebral artery[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2026, 20(05): 501-507.

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URL: https://zhnxgbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9248.2026.05.004

https://zhnxgbzz.cma-cmc.com.cn/EN/Y2026/V20/I05/501

Figures/Tables 4

项目	数值
男性[例（%）]	21（48.84）
年龄（岁， $x ¯$ ±s）	60.56±9.13
既往颅内出血史[例（%）]	6（13.95）
既往脑缺血史[例（%）]	8（18.60）
合并症[例（%）]
高血压	29（67.44）
糖尿病	7（16.28）
冠心病	4（9.30）
高脂血症	5（11.63）
入院时mRS评分[例（%）]
0分	38（88.37）
1分	5（11.63）
多发动脉瘤[例（%）]	0（0）
动脉瘤最大宽度（mm， $x ¯$ ±s）	5.51±2.22
动脉瘤最大高度（mm， $x ¯$ ±s）	5.43±2.28
瘤颈宽度（mm， $x ¯$ ±s）	3.82±1.24
动脉瘤宽/瘤颈宽[例（%）]
＜2	37（86.05）
≥2	6（13.95）
宽颈动脉瘤数量[例（%）]	40（93.02）
术前动脉瘤破裂数[例（%）]	1（2.33）

项目	数值
男性[例（%）]	21（48.84）
年龄（岁， $x ¯$ ±s）	60.56±9.13
既往颅内出血史[例（%）]	6（13.95）
既往脑缺血史[例（%）]	8（18.60）
合并症[例（%）]
高血压	29（67.44）
糖尿病	7（16.28）
冠心病	4（9.30）
高脂血症	5（11.63）
入院时mRS评分[例（%）]
0分	38（88.37）
1分	5（11.63）
多发动脉瘤[例（%）]	0（0）
动脉瘤最大宽度（mm， $x ¯$ ±s）	5.51±2.22
动脉瘤最大高度（mm， $x ¯$ ±s）	5.43±2.28
瘤颈宽度（mm， $x ¯$ ±s）	3.82±1.24
动脉瘤宽/瘤颈宽[例（%）]
＜2	37（86.05）
≥2	6（13.95）
宽颈动脉瘤数量[例（%）]	40（93.02）
术前动脉瘤破裂数[例（%）]	1（2.33）

项目	数值[例（%）]
需调整装置数量	4（9.30）
技术成功率	43（100.00）
放置辅助支架数量	0（0）
装置移位	1（2.33）
术中急性血栓事件	0（0）
术后即刻动脉瘤闭塞程度（Raymond-Roy分级）
1级	2（4.65）
2级	10（23.26）
3级	31（72.09）
术后12个月动脉瘤闭塞程度
完全闭塞	19（44.19）
充分闭塞	41（95.35）

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