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中华脑血管病杂志(电子版)

中华脑血管病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (03) : 163 -166. doi: 10.11817/j.issn.1673-9248.2020.03.009

所属专题： 专家论坛； 文献；

综述

卵圆孔未闭与不明原因脑卒中的研究进展
赵欣1, 邓燕1,†()   
  1. 1. 610072　成都，电子科技大学　四川省医学科学院?四川省人民医院超声心脏电生理学与生物力学四川省重点实验室
  • 收稿日期:2020-04-10 出版日期:2020-06-01
  • 通信作者: 邓燕
  • 基金资助:
    四川省科技厅项目(2016TD0017, 2017TD0015)

Research progress in Patent foramen ovale and cryptogenic stroke

Xin Zhao1, Yan Deng1,†()   

  1. 1. Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China
  • Received:2020-04-10 Published:2020-06-01
  • Corresponding author: Yan Deng
  • About author:
    Corresponding author: Deng Yan, Email:
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赵欣, 邓燕. 卵圆孔未闭与不明原因脑卒中的研究进展[J]. 中华脑血管病杂志(电子版), 2020, 14(03): 163-166.

Xin Zhao, Yan Deng. Research progress in Patent foramen ovale and cryptogenic stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(03): 163-166.

脑卒中是中国人口致死、致残的首要原因，其中1/3的患者脑卒中病因不明确。卵圆孔未闭在不明原因脑卒中患者中发生率高，是不明原因脑卒中的重要危险因素，其主要发病机制为反常栓塞。在临床实践中多使用经颅多普勒声学造影、经胸超声心动图声学造影及经食管超声心动图声学造影进行检测。近年来，多项大样本随机对照试验显示，与单纯药物治疗相比，经导管卵圆孔封堵结合药物治疗可明显降低不明原因脑卒中患者再卒中的发生率。

关键词: 卵圆孔未闭, 脑卒中, 诊断, 治疗, 超声

Stroke is the leading cause of death and disability in China. Among the stroke patients, cryptogenic stroke without definite causes accounted for about one third. The incidence of patent foramen ovale (PFO) in patients with cryptogenic stroke is higher than that in patients with clear cause of stroke, which is an important risk factor in cryptogenic stroke. The main pathogenesis of stroke in patients with PFO is paradoxical embolism. In clinical practice, contrast-enhanced transcranial Doppler, contrast-enhanced transthoracic echocardiography, and contrast transesophageal echocardiography are frequently used to detect PFO. In recent years, a number of large-scale randomized controlled trials have shown that percutaneous foramen ovale occlusion combined with drug therapy significantly reduced the incidence of recurrent strokes in patients with cryptogenic stroke compared with drug therapy alone.

Key words: Patent foramen ovale, Stroke, Diagnosis, Therapy, Ultrasonography
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