切换至 "中华医学电子期刊资源库"

中华脑血管病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (01) : 57 -60. doi: 10.11817/j.issn.1673-9248.2022.01.012

综述

细胞外基质金属蛋白酶诱导因子在脑卒中中的作用
刘扬1, 张锐毅1, 张艳1, 李红敏1, 苏秋羊1, 薛孟周1,()   
  1. 1. 450000 郑州大学第二附属医院脑血管病科,郑州大学脑出血疾病先进医学研究中心,河南省脑出血脑损伤国际联合实验室
  • 收稿日期:2021-01-10 出版日期:2022-02-01
  • 通信作者: 薛孟周
  • 基金资助:
    国家自然科学基金面上项目(82071331,81870942); 国家自然科学基金重点国际(地区)合作研究项目(81520108011); 国家重点研发计划项目(2018YFC1312200)

Extracellular matrix metalloproteinase inducer (CD147) in stroke

Yang Liu1, Ruiyi Zhang1, Yan Zhang1, Hongmin Li1, Qiuyang Su1, Mengzhou Xue1,()   

  1. 1. Department of Cerebrovascular Disease, the Second Affiliated Hospital of Zhengzhou University; Advanced Medical Research Center for Cerebral Hemorrhage Diseases, Zhengzhou University; Henan Provincial International Joint Laboratory for Intracerebral Hemorrhage and Brain Injury, Zhengzhou 450 000, China
  • Received:2021-01-10 Published:2022-02-01
  • Corresponding author: Mengzhou Xue
引用本文:

刘扬, 张锐毅, 张艳, 李红敏, 苏秋羊, 薛孟周. 细胞外基质金属蛋白酶诱导因子在脑卒中中的作用[J]. 中华脑血管病杂志(电子版), 2022, 16(01): 57-60.

Yang Liu, Ruiyi Zhang, Yan Zhang, Hongmin Li, Qiuyang Su, Mengzhou Xue. Extracellular matrix metalloproteinase inducer (CD147) in stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(01): 57-60.

细胞外基质金属蛋白酶诱导因子(EMMPRIN,CD147)属于免疫球蛋白超家族的跨膜糖蛋白,在多种细胞膜中广泛表达,参与机体的多种生理和病理活动(如脑卒中)。神经炎症被认为是脑卒中发病的关键因素,而EMMPRIN是神经炎症和免疫反应的关键介质。脑卒中的病理活动与EMMPRIN介导的基质金属蛋白酶(MMP)密切相关,MMP促进血脑屏障破坏和脑卒中后脑损伤。由于其高表达水平,EMMPRIN可能被用作脑卒中的诊断标志物。最近的研究表明,靶向EMMPRIN,特别是通过抗EMMPRIN(CD147)单克隆抗体在动物模型中研究,在脑卒中后具有良好的治疗潜力,为今后的临床应用提供了重要的科学依据。本综述总结了EMMPRIN在脑卒中中作用的现有实验和临床证据,并对其潜在机制提供重要的见解。

Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a transmembrane glycoprotein of the immunoglobulin superfamily, widely expressed in various cell membranes and involved in a variety of physiological and pathological activities in the body (such as stroke). Neuroinflammation is considered to be a crucial factor in the pathogenesis of stroke. EMMPRIN is a key mediator of neuroinflammation and immune response. The pathological activity of stroke is closely related to EMMPRIN-mediated matrix metalloproteinases (MMPs), which promote the destruction of the blood-brain barrier and brain injury after stroke. Because of its high expression, EMMPRIN may be used as a diagnostic marker for stroke. Recent studies have shown that targeting EMMPRIN, especially through anti-EMMPRIN (CD147) monoclonal antibodies in animal models, has good therapeutic potential for stroke, providing an important scientific basis for future clinical application. This review summarizes the available experimental and clinical evidence on the role of EMMPRIN in stroke and provides important insights into its potential mechanisms.

1
Campbell BCV, De Silva DA, Macleod MR, et al. Ischaemic stroke [J]. Nat Rev Diseas Primers, 2019, 5(1): 70.
2
An SJ, Kim TJ, Yoon BW. Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: an update [J]. J Stroke, 2017,19(1): 3-10.
3
Levine DA, Galecki AT, Langa KM, et al. Trajectory of cognitive decline after incident stroke [J]. JAMA, 2015, 314(1): 41-51.
4
Feigin VL, Roth GA, Naghavi M, et al. Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the global burden of disease study 2013 [J]. Lancet Neurol, 2016, 15(9): 913-924.
5
Leppert MH, Campbell JD, Simpson JR, et al. Cost-effectiveness of intra-arterial treatment as an adjunct to intravenous tissue-type plasminogen activator for acute ischemic stroke [J]. Stroke, 2015, 46(7): 1870-1876.
6
Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ecass, atlantis, ninds, and epithet trials [J]. Lancet, 2010, 375(9727): 1695-1703.
7
Kim JY, Bae HJ. Spontaneous intracerebral hemorrhage: management [J]. J Stroke, 2017, 19(1): 28-39.
8
O'Collins VE, Macleod MR, Donnan GA, et al. 1,026 experimental treatments in acute stroke [J]. Ann Neurol, 2006, 59(3): 467-477.
9
Macrez R, Ali C, Toutirais O, et al. Stroke and the immune system: from pathophysiology to new therapeutic strategies [J]. Lancet Neurol, 2011, 10(5): 471-480.
10
Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation [J]. Nat Med, 2011, 17(7): 796-808.
11
Seizer P, Ochmann C, Schonberger T, et al. Disrupting the EMMPRIN(CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion [J]. Arterioscl Throm Vas, 2011, 31(6): 1377-1386.
12
Agrawal SM, Yong VW. The many faces of EMMPRIN - roles in neuroinflammation [J]. Biochim Biophys Acta, 2011, 1812(2): 213-219.
13
Guo H, Li R, Zucker S, et al. EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface [J]. Cancer Res, 2000, 60(4): 888-891.
14
Patrizz A, Doran SJ, Chauhan A, et al. EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke [J]. Aging (Albany NY), 2020, 12(6): 5121-5139.
15
Jin R, Xiao AY, Chen R, et al. Inhibition of CD147 (cluster of differentiation 147) ameliorates acute ischemic stroke in mice by reducing thromboinflammation [J]. Stroke, 2017, 48(12): 3356-3365.
16
Miyauchi T, Masuzawa Y, Muramatsu T. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen [J]. J Biochem, 1991, 110(5): 770-774.
17
Biswas C, Zhang Y, DeCastro R, Guo H, et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily [J]. Cancer Res, 1995, 55(2): 434-439.
18
Yu XL, Hu T, Du JM, et al. Crystal structure of HAB18G/CD147: Implications for immunoglobulin superfamily homophilic adhesion [J]. J Biol Chem, 2008, 283(26): 18056-18065.
19
Knutti N, Kuepper M, Friedrich K, et al. Soluble extracellular matrix metalloproteinase inducer (EMMPRIN,EMN) regulates cancer-related cellular functions by homotypic interactions with surface CD147 [J]. FEBS J, 2015, 282(21): 4187-4200.
20
Miyauchi T, Kanekura T, Yamaoka A, Ozawa M, et al. Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class ii antigen [J]. J Biochem, 1990, 107(2): 316-323.
21
Kawano H, Tono T, Kadomatsu K, et al. Expression of basigin, a member of the immunoglobulin superfamily, in the mouse cochlea [J]. ORL J Otorhinolaryngol Relat Spec, 2003, 65(6): 327-331.
22
Schlosshauer B, Herzog KH. Neurothelin: an inducible cell surface glycoprotein of blood-brain barrier-specific endothelial cells and distinct neurons [J]. J Cell Biol, 1990, 110(4): 1261-1274.
23
Igakura T, Kadomatsu K, Taguchi O, et al. Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier [J]. Biochem Biophys Res Commun, 1996, 224(1): 33-36.
24
Naruhashi K, Kadomatsu K, Igakura T, et al. Abnormalities of sensory and memory functions in mice lacking bsg gene [J]. Biochem Biophys Res Commun, 1997, 236(3): 733-737.
25
Mroczko B, Groblewska M, Barcikowska M, et al. The role of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the pathophysiology of neurodegeneration: a literature study [J]. J Alzheimers Dis, 2013, 37(2): 273-283.
26
Lattanzi S, Di Napoli M, Ricci S, et al. Matrix metalloproteinases in acute intracerebral hemorrhage [J]. Neurotherapeutics, 2020, 17(2): 484-496.
27
Liu Y,Li Z,Khan S, et al. Neuroprotection of minocycline via inhibition of EMMPRIN in intracerebral hemorrhage in mice [J].Neurosci Lett, 2021, 764: 1-12.
28
Yurchenko V, Constant S, Eisenmesser E, et al. Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics [J]. Clin Exp Immunol, 2010, 160(3): 305-317.
29
Damsker JM, Okwumabua I, Pushkarsky T, et al. Targeting the chemotactic function of CD147 reduces collagen-induced arthritis [J]. Immunology, 2009, 126(1): 55-62.
30
Agrawal SM, Silva C, Tourtellotte WW, et al. EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis [J]. J Neurosci, 2011, 31(2): 669-677.
31
Wang Y, Liu G, Hong D, et al. White matter injury in ischemic stroke [J]. Prog Neurobiol, 2016, 141(1): 45-60.
32
Liu S, Jin R, Xiao AY, et al. Inhibition of CD147 improves oligodendrogenesis and promotes white matter integrity and functional recovery in mice after ischemic stroke [J]. Brain Behav Immun, 2019, 82(12): 13-24.
33
Generalized efficacy of t-PA for acute stroke. Subgroup analysis of the ninds t-PA stroke trial [J]. Stroke, 1997, 28(46): 2119-2125.
34
Kanazawa M, Takahashi T, Nishizawa M, et al. Therapeutic strategies to attenuate hemorrhagic transformation after tissue plasminogen activator treatment for acute ischemic stroke [J]. J Atheroscler Thromb, 2017, 24(3): 240-253.
35
Tu Y, Fu J, Wang J, et al. Extracellular matrix metalloproteinase inducer is associated with severity of brain oedema following experimental subarachnoid haemorrhage in rats [J]. J Int Med Res, 2012, 40(3): 1089-1098.
36
Agrawal SM, Silva C, Wang J, et al. A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: Relevance to multiple sclerosis [J]. J Neuroinflammation, 2012, 9: 64,
37
Linares G, Mayer SA. Hypothermia for the treatment of ischemic and hemorrhagic stroke [J]. Crit Care Med, 2009, 37(7): S243-S249.
38
Krieger DW, De Georgia MA, Abou-Chebl A, et al. Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke [J]. Stroke, 2001, 32(8): 1847-1854.
39
Burggraf D, Martens HK, Hamann GF. Hypothermia reduces influence of matrix metalloproteinase induction by emmprin in experimental focal cerebral ischemia [J]. J Cereb Blood Flow Metab, 2005, 25(1): S20.
40
Winchester LJ, Veeranki S, Givvimani S, et al. Homocysteine elicits an M1 phenotype in murine macrophages through an EMMPRIN-mediated pathway [J]. Can J Physiol Pharmacol, 2015, 93(7): 577-584.
[1] 欧阳剑锋, 李炳权, 叶永恒, 胡少宇, 向阳. 关节镜联合富血小板血浆治疗粘连性肩周炎的疗效[J]. 中华关节外科杂志(电子版), 2023, 17(06): 765-772.
[2] 刘立, 陈诚, 李新科, 刘凯, 屠昌明. 血清IL-6、hs-CRP、MMP-9联合检测在腹股沟疝无张力修补术预后评价中的价值分析[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(04): 405-409.
[3] 刘小燕, 龙乾发, 席俊秀, 杜明皓, 黄晓欢. 细胞外囊泡介导的胶质细胞交互作用对神经炎症的调节意义及研究进展[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(04): 235-241.
[4] 尚慧娟, 袁晓冬. 机械取栓术后应用依达拉奉右崁醇对急性缺血性脑卒中预后的改善[J]. 中华神经创伤外科电子杂志, 2023, 09(05): 295-301.
[5] 运陌, 李茂芳, 王浩, 刘东远. 微创穿刺引流联合吡拉西坦、乌拉地尔治疗基底节区高血压性脑出血的临床研究[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 278-285.
[6] 廖家权, 吴波, 唐昌敏. 体外冲击波联合肌电生物反馈对脑卒中后足下垂的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 286-292.
[7] 许方军, 曹晓光, 王修敏, 董学超, 刘云卫, 彭云飞, 周康. 虚拟情景互动技术联合肩胛骨运动控制强化训练对偏瘫患者上肢功能及日常生活活动能力的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(04): 222-228.
[8] 侯牧韶, 刘子渤, 李红玲. 局部振动疗法治疗脑卒中后运动障碍的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(04): 246-250.
[9] 孙畅, 赵世刚, 白文婷. 脑卒中后认知障碍与内分泌激素变化的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 471-476.
[10] 张许平, 刘佳成, 张舸, 杜艳姣, 李韶, 商丹丹, 王浩, 李艳, 段智慧. CYP2C19基因多态性联合血栓弹力图指导大动脉粥样硬化型非致残性缺血性脑血管事件患者抗血小板治疗的效果[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 477-481.
[11] 杨海华, 袁景林, 周晓梅, 牛军伟. RNF213基因突变所致烟雾病一家系病例临床分析并文献复习[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 495-498.
[12] 李昕, 李永凯, 江树青, 夏来百提姑·赛买提, 杨建中. 急性缺血性脑卒中静脉溶栓后出血转化相关危险因素分析[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 331-336.
[13] 邓颖, 黄山, 胡慧秀, 孙超. 老年缺血性脑卒中患者危险因素聚集情况分析[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 344-349.
[14] 祁研, 张岩, 陈雪, 刘颖, 史楠. 探讨高低频交互rTMS对老年脑卒中偏瘫患者肢体功能、吞咽功能及日常生活活动能力的影响[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 359-363.
[15] 刘天姿, 王宝军. Toll样受体4在阿尔茨海默病中的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 404-409.
阅读次数
全文


摘要