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中华脑血管病杂志(电子版)

中华脑血管病杂志(电子版) ›› 2022, Vol. 16 ›› Issue (04) : 280 -283. doi: 10.11817/j.issn.1673-9248.2022.04.011

综述

卒中后运动功能障碍的脑结构-功能网络改变研究进展
李玉洁1, 陈蓉1,†()   
  1. 1. 570100　海口，海南医学院第一附属医院神经内科
  • 收稿日期:2021-08-14 出版日期:2022-08-01
  • 通信作者: 陈蓉
  • 基金资助:
    海南省自然科学基金高层次人才项目(2019RC379); 海南省临床医学中心建设项目

Research progress of brain structure-function network changes in motor dysfunction after acute stroke

Yujie Li1, Rong Chen1,†()   

  1. 1. Department of Neurology, First Affiliated Hospital of Hainan Medical College, Haikou 570100, China
  • Received:2021-08-14 Published:2022-08-01
  • Corresponding author: Rong Chen
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李玉洁, 陈蓉. 卒中后运动功能障碍的脑结构-功能网络改变研究进展[J]. 中华脑血管病杂志(电子版), 2022, 16(04): 280-283.

Yujie Li, Rong Chen. Research progress of brain structure-function network changes in motor dysfunction after acute stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(04): 280-283.

脑功能网络是指通过静息态功能磁共振血氧水平依赖性（BOLD）信号的时间相关性成像原理来呈现的大脑空间相隔区域之间功能连接网络。脑结构连接性是通过弥散磁共振的水分子弥散各向异性成像原理，来追踪白质纤维束的走行及结构连接网络。功能磁共振在脑结构-功能连接的相关研究中担任着交通纽枢的角色。功能磁共振技术是探讨脑梗死后脑结构-功能网络改变的重要技术手段，弥散张量成像技术可以使神经纤维可视化，直观地观察神经纤维受损的严重程度，但不能反映脑功能网络的变化，静息态功能磁共振成像可以反映脑相隔区域的BOLD信号变化的时间相关性，间接反映脑功能网络的变化。本综述基于脑梗死探讨卒中后运动功能障碍患者脑结构-功能网络改变的研究进展，总结卒中后运动功能障碍患者脑结构-功能网络改变对脑功能预后及康复疗效评估的价值。

关键词: 脑功能网络, 功能磁共振, 运动功能障碍

The brain function network refers to the time-correlated imaging principle of resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal to present the functional connection network among the spatially separated areas of the brain. The brain structure connectivity is detected by the diffusion magnetic resonance of water. The molecular diffusion anisotropy imaging principle is used to track the white matter fiber bundles and the structural connection network. fMRI plays a critical hub in the related research of brain structure-function connection. fMRI is an important technology to explore the changes in brain structure-function network after cerebral infarction. Diffusion tensor imaging can visualize nerve fibers and intuitively observe the severity of nerve fiber damage, but it cannot reflect changes in brain functional networks. Resting-state fMRI can reflect the time correlation of the BOLD signal changes in the separated areas of the brain, and indirectly reflect the changes in the brain functional network. This review is to explore the brain structure-function network changes in patients with motor dysfunction after cerebral infarction, and summarizes the prognostic value of brain structure-function network changes in patients with post-stroke motor dysfunction.

Key words: Brain function network, Functional magnetic resonance imaging, Motor dysfunction
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