Advances in risk assessment of new-onset atrial fibrillation

doi:10.11817/j.issn.1673-9248.2020.03.003

Abstract

Abstract:

Atrial fibrillation (AF) increases the risk of ischemic stroke, heart failure, all-cause mortality and cognitive dysfunction. Identifying risk factors for incident AF is pivotal for making strategies for primary prevention, silent AF screening or detection, and improving AF-related clinical prognosis. The most common clinical risk factors for AF include age, male gender, smoking, drinking, obesity, obstructive sleep apnea, hypertension, coronary artery disease, heart failure, hyperthyroidism, diabetes, chronic obstructive pulmonary disease, chronic kidney disease, etc. The novel HAVOC and C₂HEST score are the promising and simple clinical risk assessment tools for incident AF.

Key words: Atrial fibrillation, Risk factors, Risk assessment

Yanguang Li, Lingyun Zu, Shuwang Liu. Advances in risk assessment of new-onset atrial fibrillation[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(03): 133-139.

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评分工具	第一作者	来源队列	研究对象数量	C值^a	所含变量
Framingham	Schnabel RB^[39]	FHS队列（美国）	4764	0.78（0.76~0.80）	年龄、性别、心脏杂音、心力衰竭、收缩压、高血压、体质量指数、PR间期
CHARGE-AF	Alonso A^[21]	ARIC、CHS、FHS队列（美国）	18 556	0.77（0.75~0.78）	年龄、种族、身高、体质量、血压、吸烟、降压药物、糖尿病、心肌梗死、心力衰竭
ARIC	Chamberlain AM^[40]	ARIC队列（美国）	14 546	0.78（N/A）	年龄、种族、身高、吸烟、收缩压、降压药物、心脏杂音、左心室肥厚、左心房扩张、糖尿病、冠心病、心力衰竭
C₂HEST	Li YG^[43]	云南医保数据库（中国）、韩国医保数据库（韩国）	471 446和451 199	0.75（0.73~0.77）	冠心病、慢性阻塞性肺病、高血压、高龄、心力衰竭、甲状腺功能亢进
HAVOC	Kwong C^[42]	STRIDE数据库（美国）	9689	0.77（N/A）	高血压、年龄、瓣膜性心脏病、外周血管病、肥胖、心力衰竭、冠心病
CHASE-LESS	Hsieh CY^[44]	台湾数据库	17 076	0.73（0.71~0.75）	冠心病、年龄、心力衰竭、卒中严重程度、高脂血症、既往卒中或短暂性脑缺血发作
EHR	Hulme OL^[41]	多中心电子病历数据库（美国）	412 085	0.78（0.77~0.78）	性别、年龄、种族、吸烟、身高、体质量、舒张压、高血压、高脂血症、心力衰竭、冠心病、瓣膜病、卒中、外周动脉疾病、慢性肾病、甲状腺功能减低

评分工具	第一作者	来源队列	研究对象数量	C值^a	所含变量
Framingham	Schnabel RB^[39]	FHS队列（美国）	4764	0.78（0.76~0.80）	年龄、性别、心脏杂音、心力衰竭、收缩压、高血压、体质量指数、PR间期
CHARGE-AF	Alonso A^[21]	ARIC、CHS、FHS队列（美国）	18 556	0.77（0.75~0.78）	年龄、种族、身高、体质量、血压、吸烟、降压药物、糖尿病、心肌梗死、心力衰竭
ARIC	Chamberlain AM^[40]	ARIC队列（美国）	14 546	0.78（N/A）	年龄、种族、身高、吸烟、收缩压、降压药物、心脏杂音、左心室肥厚、左心房扩张、糖尿病、冠心病、心力衰竭
C₂HEST	Li YG^[43]	云南医保数据库（中国）、韩国医保数据库（韩国）	471 446和451 199	0.75（0.73~0.77）	冠心病、慢性阻塞性肺病、高血压、高龄、心力衰竭、甲状腺功能亢进
HAVOC	Kwong C^[42]	STRIDE数据库（美国）	9689	0.77（N/A）	高血压、年龄、瓣膜性心脏病、外周血管病、肥胖、心力衰竭、冠心病
CHASE-LESS	Hsieh CY^[44]	台湾数据库	17 076	0.73（0.71~0.75）	冠心病、年龄、心力衰竭、卒中严重程度、高脂血症、既往卒中或短暂性脑缺血发作
EHR	Hulme OL^[41]	多中心电子病历数据库（美国）	412 085	0.78（0.77~0.78）	性别、年龄、种族、吸烟、身高、体质量、舒张压、高血压、高脂血症、心力衰竭、冠心病、瓣膜病、卒中、外周动脉疾病、慢性肾病、甲状腺功能减低

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