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Chinese Journal of Cerebrovascular Diseases(Electronic Edition) ›› 2026, Vol. 20 ›› Issue (04): 365-371. doi: 10.3877/cma.j.issn.1673-9248.2026.04.003

• Original Article • Previous Articles    

Predictive value of the cholesterol-high density lipoprotein cholesterol-glucose index for clinical outcomes in patients undergoing thrombectomy for acute basilar artery occlusion

Zhizhong Yan1, Xu Zhang1, Junhui Chen1, Jiaming Cao1, Qiwen Zhao1, Liuyan Shen1, Zhonghua Shi1, Qingwu Yang2,(), Yuhai Wang1,()   

  1. 1 Department of Neurosurgery, 904th Hospital of the Joint Logistics Support Force of Chinese People's Liberation Army, Wuxi 214000, China
    2 Department of Neurology, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, China
  • Received:2026-07-08 Online:2026-08-01 Published:2026-09-08
  • Contact: Qingwu Yang, Yuhai Wang

Abstract:

Objective

To explore the predictive value of the cholesterol-high density lipoprotein cholesterol-glucose (CHG) index for outcomes in patients with acute basilar artery occlusion (aBAO) undergoing endovascular treatment (EVT).

Methods

Data were derived from the prospective BASILAR registry study. Patients were stratified into quartiles (Q1-Q4) based on the admission CHG index: Q1 (-0.25 to 3.68), Q2 (>3.68 to 4.25), Q3 (>4.25 to 4.82), and Q4 (>4.82 to 7.91). The follow-up period was 1 year post-EVT. The primary outcome was favorable functional outcome at 1 year post-EVT, defined as a modified Rankin scale (mRS) score ≤3. Secondary outcomes included favorable functional outcome at 90-day after EVT. Safety endpoints comprised 90-day all-cause mortality, symptomatic intracranial hemorrhage within 48 hours, and procedure-related complications. Normally distributed continuous data were compared across groups using one-way ANOVA, whereas non-normally distributed data were analyzed using the Kruskal-Wallis H test. Categorical variables were compared using the χ2 test or Fisher's exact test. Multivariate Logistic regression was used to analyze the association between the CHG index and poor functional outcome (mRS score >3) by odds ratios (OR) with 95% confidence intervals (CI).

Results

A total of 396 aBAO patients treated with EVT were included, with 99 patients in each quartile. Significant differences were observed among the quartiles in age, smoking history, hypertension, type 2 diabetes, hyperlipidemia, uric acid, lipid profile, blood glucose, glycated hemoglobin, and coagulation indicators (all P<0.05). Regarding clinical outcomes, both the successful recanalization rate [modified thrombolysis in cerebral infarction (mTICI) scale 2c-3: 68.69%, 68.69%, 57.58%, and 48.48% for Q1-Q4, respectively; χ2=11.905, P=0.008] and the rate of favorable functional outcome at 1 year (48.48%, 44.44%, 32.32%, and 31.31%; χ2=9.276, P=0.026) exhibited a significant decreasing trend with increasing CHG index. Multivariate logistic regression showed that each 1-standard-deviation increase in the CHG index was associated with a 41% increased risk of poor outcome (OR=1.41, 95%CI: 1.13-1.76, P=0.002).

Conclusion

An elevated CHG index may serve as an independent predictor of poor 1-year functional outcomes in aBAO patients undergoing EVT. Preoperative assessment of the CHG index might facilitate clinical risk stratification.

Key words: Cholesterol-high density lipoprotein cholesterol-glucose index, Acute basilar artery occlusion, Thrombectomy, Functional outcome, Prediction

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