Clinical application of arterial spin labeling in acute ischemic stroke

doi:10.11817/j.issn.1673-9248.2020.03.006

Abstract

Abstract:

Arterial Spin Labeling (ASL) is a noninvasive imaging technique without contrast agents. Through different imaging features such as ischemic penumbra and collateral flow, ASL can help to recognize ischemic stroke and predict prognosis. Multi-delay ASL is improved on the basis of the original technique, which makes it more widely used in cerebrovascular diseases. This article reviewed the value of ASL and its clinical application in the diagnosis of acute ischemic stroke, in which the multi-delay ASL is mainly introduced.

Key words: Stroke, Arterial spin labeling, Magnetic resonance imaging

Chuming Yan, Qingfeng Ma. Clinical application of arterial spin labeling in acute ischemic stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(03): 151-154.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhnxgbzz.cma-cmc.com.cn/EN/10.11817/j.issn.1673-9248.2020.03.006

https://zhnxgbzz.cma-cmc.com.cn/EN/Y2020/V14/I03/151

References 43

1	GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 [J]. Lancet Neurol, 2019, 18(05): 439-458.
2	Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct [J]. N Engl J Med, 2018, 378(01): 11-21.
3	Albers GW, Marks MP, Kemp S, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging [J]. N Engl J Med, 2018, 378(08): 708-718.
4	Detre JA, Leigh JS, Williams DS, et al. Perfusion imaging [J]. Magn Reson Med, 1992, 23(01): 37-45.
5	Bokkers RP, Bremmer JP, van Berckel BN, et al. Arterial spin labeling perfusion MRI at multiple delay times: a correlative study with H(2)(15)O positron emission tomography in patients with symptomatic carotid artery occlusion [J]. J Cereb Blood Flow Metab, 2010, 30(01): 222-229.
6	Wang DJ, Alger JR, Qiao JX, et al. The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced MRI [J]. Stroke, 2012, 43(04): 1018-1024.
7	Bivard A, Krishnamurthy V, Stanwell P, et al. Arterial spin labeling versus bolus-tracking perfusion in hyperacute stroke [J]. Stroke, 2014, 45(01): 127-133.
8	Alsop DC, Detre JA, Golay X, et al. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia [J]. Magn Reson Med, 2015, 73(01): 102-116.
9	Dai W, Fong T, Jones RN, et al. Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort [J]. J Magn Reson Imaging, 2017, 45(02): 472-481.
10	Bokkers RP, Hernandez DA, Merino JG, et al. Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke [J]. Stroke, 2012, 43(05): 1290-1294.
11	Buxton RB, Frank LR, Wong EC, et al. A general kinetic model for quantitative perfusion imaging with arterial spin labeling [J]. Magn Reson Med, 1998, 40(03): 383-396.
12	Petersen ET, Mouridsen K, Golay X. The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study [J]. NeuroImage, 2010, 49(01): 104-113.
13	Wang DJ, Alger JR, Qiao JX, et al. Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke-Comparison with dynamic susceptibility contrast enhanced perfusion imaging [J]. Neuroimage Clin, 2013, 03(01): 1-7.
14	Nael K, Meshksar A, Liebeskind DS, et al. Quantitative analysis of hypoperfusion in acute stroke: arterial spin labeling versus dynamic susceptibility contrast [J]. Stroke, 2013, 44(11): 3090-3096.
15	Huang YC, Liu HL, Lee JD, et al. Comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MRI in patients with acute stroke [J]. PloS One, 2013, 08(07): e69085.
16	Zaharchuk G, El Mogy IS, Fischbein NJ, et al. Comparison of arterial spin labeling and bolus perfusion-weighted imaging for detecting mismatch in acute stroke [J]. Stroke, 2012, 43(07): 1843-1848.
17	Nam KW, Kim CK, Ko SB, et al. Regional Arterial Spin Labeling Perfusion Defect Is Associated With Early Ischemic Recurrence in Patients With a Transient Ischemic Attack [J]. Stroke, 2020, 51(01): 186-192.
18	Niibo T, Ohta H, Yonenaga K, et al. Arterial spin-labeled perfusion imaging to predict mismatch in acute ischemic stroke [J]. Stroke, 2013, 44(09): 2601-2603.
19	Song K, Guan M, Li W, et al. Acute ischemic stroke patients with diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score </= 5 can benefit from endovascular treatment: a single-center experience and literature review [J]. Neuroradiology, 2019, 61(04): 451-459.
20	Puhr-Westerheide D, Tiedt S, Rotkopf LT, et al. Clinical and Imaging Parameters Associated With Hyperacute Infarction Growth in Large Vessel Occlusion Stroke [J]. Stroke, 2019, 50(10): 2799-2804.
21	Morofuji Y, Horie N, Tateishi Y, et al. Arterial Spin Labeling Magnetic Resonance Imaging Can Identify the Occlusion Site and Collateral Perfusion in Patients with Acute Ischemic Stroke: Comparison with Digital Subtraction Angiography [J]. Cerebrovasc Dis, 2019, 48(NaN): 70-76.
22	Niibo T, Ohta H, Miyata S, et al. Prediction of Blood-Brain Barrier Disruption and Intracerebral Hemorrhagic Infarction Using Arterial Spin-Labeling Magnetic Resonance Imaging [J]. Stroke, 2017, 48(01): 117-122.
23	Sobesky J, Thiel A, Ghaemi M, et al. Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusion [J]. J Cereb Blood Flow Metab, 2005, 25(12): 1685-1691.
24	Takasawa M, Watanabe M, Yamamoto S, et al. Prognostic value of subacute crossed cerebellar diaschisis: single-photon emission CT study in patients with middle cerebral artery territory infarct [J]. AJNR Am J Neuroradiol, 2002, 23(02): 189-193.
25	Strother MK, Buckingham C, Faraco CC, et al. Crossed cerebellar diaschisis after stroke identified noninvasively with cerebral blood flow-weighted arterial spin labeling MRI [J]. Eur J Radiol, 2016, 85(01): 136-142.
26	Shinohara Y, Kato A, Kuya K, et al. Perfusion MR Imaging Using a 3D Pulsed Continuous Arterial Spin-Labeling Method for Acute Cerebral Infarction Classified as Branch Atheromatous Disease Involving the Lenticulostriate Artery Territory [J]. AJNR Am J Neuroradiol, 2017, 38(08): 1550-1554.
27	Kang KM, Sohn CH, Choi SH, et al. Detection of crossed cerebellar diaschisis in hyperacute ischemic stroke using arterial spin-labeled MR imaging [J]. PloS One, 2017, 12(03): e0173971.
28	Berkhemer OA, Jansen IG, Beumer D, et al. Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke [J]. Stroke, 2016, 47(03): 768-776.
29	Broocks G, Kemmling A, Meyer L, et al. Computed Tomography Angiography Collateral Profile Is Directly Linked to Early Edema Progression Rate in Acute Ischemic Stroke [J]. Stroke, 2019, 50(12): 3424-3430.
30	Flores A, Rubiera M, Ribo M, et al. Poor Collateral Circulation Assessed by Multiphase Computed Tomographic Angiography Predicts Malignant Middle Cerebral Artery Evolution After Reperfusion Therapies [J]. Stroke, 2015, 46(11): 3149-3153.
31	Deibler AR, Pollock JM, Kraft RA, et al. Arterial spin-labeling in routine clinical practice, part 3: hyperperfusion patterns [J]. AJNR Am J Neuroradiol, 2008, 29(08): 1428-1435.
32	Zaharchuk G, Do HM, Marks MP, et al. Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease [J]. Stroke, 2011, 42(09): 2485-2491.
33	Crisi G, Filice S, Scoditti U. Arterial Spin Labeling MRI to Measure Cerebral Blood Flow in Untreated Ischemic Stroke [J]. J Neuroimaging, 2019, 29(02): 193-197.
34	Nael K, Meshksar A, Liebeskind DS, et al. Periprocedural arterial spin labeling and dynamic susceptibility contrast perfusion in detection of cerebral blood flow in patients with acute ischemic syndrome [J]. Stroke, 2013, 44(03): 664-670.
35	Thamm T, Guo J, Rosenberg J, et al. Contralateral Hemispheric Cerebral Blood Flow Measured With Arterial Spin Labeling Can Predict Outcome in Acute Stroke [J]. Stroke, 2019, 50(12): 3408-3415.
36	Lee S, Park DW, Kim TY, et al. A novel visual ranking system based on arterial spin labeling perfusion imaging for evaluating perfusion disturbance in patients with ischemic stroke [J]. PloS One, 2020, 15(01): e0227747.
37	Yu S, Ma SJ, Liebeskind DS, et al. ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients [J]. J Cereb Blood Flow Metab, 2018, 38(03): 382-392.
38	Wang K, Shou Q, Ma SJ, et al. Deep Learning Detection of Penumbral Tissue on Arterial Spin Labeling in Stroke [J]. Stroke, 2019, 51(02):489-497.
39	Kanazawa Y, Arakawa S, Shimogawa T, et al. Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke from Epileptic Disorders [J]. J Stroke Cerebrovasc Diseases, 2019, 28(06): 1684-1690.
40	Tian B, Liu Q, Wang X, et al. Chronic intracranial artery stenosis: Comparison of whole-brain arterial spin labeling with CT perfusion [J]. Clin Imaging, 2018, 52: 252-259.
41	Lou X, Yu S, Scalzo F, et al. Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke [J]. Oncotarget, 2017, 08(02): 2437-2443.
42	Lyu J, Ma N, Liebeskind DS, et al. Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis [J]. Stroke, 2016, 47(02): 428-433.
43	Okell TW, Harston GWJ, Chappell MA, et al. Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study [J]. Sci Rep, 2019, 09(01): 8181.

[1]	Lianlian Zhang, Pinjing Hui, Yafang Ding. Clinical value of carotid Doppler ultrasonography in assessing vulnerability of atherosclerotic plaques [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(08): 816-821.
[2]	Xiaoyan Dong, Qi Zhao, Jun Tang, Li Zhang, Xiaoyan Yang, Jiao Li. Clinical characteristics of neonates infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 595-603.
[3]	Yu Han, Wu Zhang, Anqi Li, Wenying Chen, Sidong Xie. Diagnostic value of MRI Liver Image Reporting and Data System (LI-RADS) for hepatocellular carcinoma in patients with non-cirrhotic hepatitis B [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 669-673.
[4]	Manshi Lei, Sisi Deng, Xinrong Wang, Jinbin Huang, Qing Xiang, Anni Xiong, Zhan'ao Meng. Application of artificial intelligence-assisted compression sensing technology in upper abdominal fat-suppressed T2WI sequence [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 551-556.
[5]	Qinglin Li, Renjie Song, Feihu Zhou. Establishment and exploration of a mouse model of severe exertional heat stroke-related acute kidney injury [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(05): 265-270.
[6]	Huijuan Shang, Xiaodong Yuan. Improvement of prognosis of acute cerebral ischemic stroke with edaravone dexkanol after mechanical thrombectomy [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(05): 295-301.
[7]	Jiaquan Liao, Bo Wu, Changmin Tang. Effect of extracorporeal shock wave combined with myoelectric biofeedback on foot drop after stroke [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(05): 286-292.
[8]	Guangjun Zhong, Chunhua Liu, Wansen Zhu, Xiaolei Xu, Zhaojun Wang. Application of conventional MRI combined with different scanning sequences in preoperative staging diagnosis, chemotherapy efficacy and prognosis evaluation of gastric cancer [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 378-382.
[9]	Baoru Hu, Naijian Shang, Di Gao. DCE-MRI and DWI findings of advanced hepatocellular carcinoma and their correlation with prognosis after immunotherapy [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 399-403.
[10]	Yuxian Wu, Yayuan Feng, Lei Huo, Ningyang Jia, Juan Zhang. Study on the diagnostic value of imaging in primary hepatic lymphoma [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(05): 349-353.
[11]	Hongyang Sun, Ji Liu, Zixiang Gong, Guangying Wang, Zhaoteng Ning, Xuan Zhao, Qiyi Zhu, Xianjun Wang. Clinical prognosis and timing of endovascular treatment for minor stroke patients with acute anterior circulation large vessel occlusive [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 445-451.
[12]	Chang Sun, Shigang Zhao, Wenting Bai. The relationship between the cognitive impairment after stroke and the hormone levels [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 471-476.
[13]	Xuping Zhang, Jiacheng Liu, Ge Zhang, Yanjiao Du, Shao Li, Dandan Shang, Hao Wang, Yan Li, Zhihui Duan. CYP2C19 gene polymorphism combined with thromboelastogram-guided antiplatelet therapy for patients with the large artery atherosclerosis and non-disabling ischemic cerebrovascular events (NICE) [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 477-481.
[14]	Haihua Yang, Jinglin Yuan, Xiaomei Zhou, Junwei Niu. A novel missense variant of RNF213 in a family with moyamoya disease: A case report and literature review [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 495-498.
[15]	Zeping Jin, Jing Dong, Yunpeng Liu, Yang Wang. Correlation between microbiota-gut-brain axis and the risk factors of ischemic stroke [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 510-517.

Please choose a citation manager

Content to export