Advances in the study of metabolic syndrome and vascular cognitive impairment

doi:10.11817/j.issn.1673-9248.2020.04.010

Abstract

Abstract:

Metabolic syndrome is a group of clinical syndromes characterized by central obesity, impaired glucose regulation or diabetes, disorder of lipid metabolism and hypertension. Insulin resistance is the common pathophysiological basis of them. Vascular cognitive impairment (VCI) can be present as a clinical stroke or subclinical vascular brain injury, involving at least one cognitive damaged domain. It is caused by cerebrovascular disease and its risk factors. This article reviewed the relationship between metabolic syndrome and VCI, and the mechanism of metabolic syndrome leading to VCI.

Key words: Metabolic syndrome, Vascular cognitive impairment, Cerebrovascular disease

Yunfeng Han, Xuan Lai, Jun Yang, Changcheng Ma. Advances in the study of metabolic syndrome and vascular cognitive impairment[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(04): 234-237.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhnxgbzz.cma-cmc.com.cn/EN/10.11817/j.issn.1673-9248.2020.04.010

https://zhnxgbzz.cma-cmc.com.cn/EN/Y2020/V14/I04/234

References 43

1	Skrobot OA, Black SE, Chen C, et al. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study [J]. Alzheimers Dement, 2018, 14(3): 280-292.
2	Satizabal CL, Beiser AS, Chouraki V, et al. Incidence of dementia over three decades in the Framingham Heart Study [J]. N Engl J Med, 2016, 374(6): 523-532.
3	Norton S, Matthews FE, Barnes DE, et al. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data [J]. Lancet Neurol, 2014, 13(8): 788-794.
4	Skrobot OA, O'Brien J, Black S, et al. The vascular impairment of cognition classification consensus study [J]. Alzheimers Dement, 2017, 13(6): 624-633.
5	中国医师协会神经内科分会认知障碍专业委员会编写组. 2019年中国血管性认知障碍诊治指南 [J]. 中华医学杂志, 2019, 99(35): 2737-2744.
6	Jia J, Wang F, Wei C, et al. The prevalence of dementia in urban and rural areas of China [J]. Alzheimers Dement, 2014, 10(1): 1-9.
7	Jia J, Zhou A, Wei C, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese [J]. Alzheimers Dement, 2014, 10(4): 439-447.
8	Sharp SI, Aarsland D, Day S, et al. Hypertension is a potential risk factor for vascular dementia: systematic review [J]. Int J Geriatr Psychiatry, 2011, 26(7): 661-669.
9	Moll VCE, Richard E, Eurelings LS, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial [J]. Lancet, 2016, 388(10046): 797-805.
10	Kavirajan H, Schneider LS. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials [J]. Lancet Neurol, 2007, 6(9): 782-792.
11	Qizilbash N, Gregson J, Johnson ME, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study [J]. Lancet Diabetes Endocrinol, 2015, 3(6): 431-436.
12	Noh HM, Han J, Kim YJ, et al. Sex differences in the relationship between cognitive impairment and overweight or obesity in late life: A 3-year prospective study [J]. Medicine (Baltimore), 2019, 98(9): e14736.
13	Hou Q, Guan Y, Yu W, et al. Associations between obesity and cognitive impairment in the Chinese elderly: an observational study [J]. Clin Interv Aging, 2019, 14: 367-373.
14	Wang F, Zhao M, Han Z, et al. Association of body mass index with amnestic and non-amnestic mild cognitive impairment risk in elderly [J]. BMC Psychiatry, 2017, 17(1): 334.
15	Arnoldussen I, Gustafson DR, Leijsen E, et al. Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC study [J]. Neurology, 2019, 93(9): e864-e878.
16	West NA, Lirette ST, Cannon VA, et al. Adiposity, change in adiposity, and cognitive decline in mid- and late Life [J]. J Am Geriatr Soc, 2017, 65(6): 1282-1288.
17	Zhang T, Yan R, Chen Q, et al. Body mass index, waist-to-hip ratio and cognitive function among Chinese elderly: a cross-sectional study [J]. BMJ Open, 2018, 8(10): e22055.
18	Albanese E, Launer LJ, Egger M, et al. Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies [J]. Alzheimers Dement (Amst), 2017, 8: 165-178.
19	Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease [J]. Int J Mol Sci, 2014, 15(4): 6184-6223.
20	Miller AA, Spencer SJ. Obesity and neuroinflammation: a pathway to cognitive impairment [J]. Brain Behav Immun, 2014, 42: 10-21.
21	Hsieh CC, Chou MJ, Wang CH. Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production [J]. PLoS One, 2017, 12(2): e171969.
22	Elias MF, Goodell AL, Dore GA. Hypertension and cognitive functioning: a perspective in historical context [J]. Hypertension, 2012, 60(2): 260-268.
23	Santisteban MM, Iadecola C. Hypertension, dietary salt and cognitive impairment [J]. J Cereb Blood Flow Metab, 2018, 38(12): 2112-2128.
24	Gottesman RF, Schneider AL, Albert M, et al. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study [J]. JAMA Neurol, 2014, 71(10): 1218-1227.
25	Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J]. Lancet Neurol, 2013, 12(8): 822-838.
26	Huijts M, Duits A, Staals J, et al. Basal ganglia enlarged perivascular spaces are linked to cognitive function in patients with cerebral small vessel disease [J]. Curr Neurovasc Res, 2014, 11(2): 136-141.
27	Benjamin P, Lawrence AJ, Lambert C, et al. Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease [J]. Neuroimage Clin, 2014, 4: 828-837.
28	Zeestraten EA, Lawrence AJ, Lambert C, et al. Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease [J]. Neurology, 2017, 89(18): 1869-1876.
29	Gao Z, Wang W, Wang Z, et al. Cerebral microbleeds are associated with deep white matter hyperintensities, but only in hypertensive patients [J]. PLoS One, 2014, 9(3): e91637.
30	Moroney JT, Tang MX, Berglund L, et al. Low-density lipoprotein cholesterol and the risk of dementia with stroke [J]. JAMA, 1999, 282(3): 254-260.
31	de Oliveira J, Engel DF, de Paula GC, et al. LDL receptor deficiency does not alter brain amyloid-beta levels but causes an exacerbation of apoptosis [J]. J Alzheimers Dis, 2020, 73(2): 585-596.
32	Alzoubi KH, Khabour OF, Salah HA, et al. Vitamin E prevents high-fat high-carbohydrates diet-induced memory impairment: the role of oxidative stress [J]. Physiol Behav, 2013, 119: 72-78.
33	Sawmiller D, Habib A, Hou H, et al. A novel apolipoprotein E antagonist functionally blocks apolipoprotein E interaction with N-terminal amyloid precursor protein, reduces beta-amyloid-associated pathology, and improves cognition [J]. Biol Psychiatry, 2019, 86(3): 208-220.
34	Chuang YF, Hayden KM, Norton MC, et al. Association between APOE epsilon4 allele and vascular dementia: The Cache County study [J]. Dement Geriatr Cogn Disord, 2010, 29(3): 248-253.
35	Han Y, Zhou A, Li F, et al. Apolipoprotein E epsilon4 allele is associated with vascular cognitive impairment no dementia in Chinese population [J]. J Neurol Sci, 2019, 409: 116606.
36	Menezes AR, Lavie CJ, Milani RV, et al. The effects of statins on prevention of stroke and dementia: a review [J]. J Cardiopulm Rehabil Prev, 2012, 32(5): 240-249.
37	Ebady SA, Arami MA, Shafigh MH. Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment [J]. Diabetes Res Clin Pract, 2008, 82(3): 305-309.
38	Neth BJ, Craft S. Insulin resistance and alzheimer's disease: Bioenergetic Linkages [J]. Front Aging Neurosci, 2017, 9: 345.
39	de la Monte SM. Insulin resistance and Alzheimer's disease [J]. BMB Rep, 2009, 42(8): 475-481.
40	Reese LC, Laezza F, Woltjer R, et al. Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-alpha in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease [J]. J Neurochem, 2011, 119(4): 791-804.
41	Li X, Gao Y, Meng Z, et al. Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment [J]. Exp Ther Med, 2016, 11(5): 1993-1998.
42	Jin L, Li YP, Feng Q, et al. Cognitive deficits and Alzheimer-like neuropathological impairments during adolescence in a rat model of type 2 diabetes mellitus [J]. Neural Regen Res, 2018, 13(11): 1995-2004.
43	Murillo OB, Ramirez EJ, Ramos-Rodriguez E, et al. Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes [J]. World J Diabetes, 2016, 7(20): 615-620.

[1]	Xiyan Zheng, Zheng Zhou, Fangping He, Zhiqun Lin, Fei Du, Qin Xie, Shaoping Wang, Xianjie Shi. Risk factors for the prognosis of metabolic syndrome and hepatitis B virus related hepatocellular carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(02): 104-109.
[2]	Mengqi Yang, Huifen Ma, Yang Zi, Nan Wang, Bingyu Du, Wanpeng Chang, Shaohong Yu. Research progress of yerba mate tea on prevention and treatment of cerebrovascular disease [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(04): 235-240.
[3]	Jun Li, Lianting Ma. Establishment of multi-mode three-dimensional image fusion technology system and its application in diagnosis and treatment of cerebrovascular disease [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2023, 13(03): 129-134.
[4]	Zhiwei Liu, Liting Zhao, Zhirong Yu, Youpeng Chen. Relationship between metabolic syndrome and colorectal tubular villous adenoma [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(04): 215-219.
[5]	Guoying Zhu, Li Chen, Yongnian Ding, Changqing Yang, Fengshang Zhu. Pay attention to basic and clinical research of fatty pancreas [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2022, 12(03): 129-132.
[6]	Lianchao Jin, Bing Yang, Zhe Zhou, Dongliang Pan, Zunke Xie. Correlation of metabolic syndrome and stress urinary incontinence in women [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2023, 09(02): 109-113.
[7]	Shijin Liu, Yiran Zhang, Hui Ding, Xiaoxu Zhao, Yunlong Pan. Metabolic syndrome and telomere status in the prognosis of patients with colorectal cancer [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(04): 231-235.
[8]	Huizhen Luo, Weixiong Ye, Xuwei Cai, Baowen Du. The effect of obese children with obstructive sleep apnea-hypopnea syndrome on growth and development and metabolic indexes [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(03): 164-168.
[9]	Xinyu Bi, Jinfeng Xiao, Chonggui Zhu, Longhao Sun, Jin Cui, Qing He, Xiaoyu Liang. Analysis of preoperative pituitary MRI and related hormone levels in patients with bariatric surgery [J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2022, 08(03): 159-163.
[10]	Mingyue Bai, Shuna Yang, Hongmei Hu, Wenli Hu. Research status and mechanism exploration on the prevalence of cerebrovascular disease in dialysis patients [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 505-509.
[11]	Ganzhe Liu, Fen Ai. MiRNA-210 improved vascular cognitive impairment in rats by inhibiting HIF-1α expression [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 489-494.
[12]	Zheng Luo, Wei Zhang, Xiaoyun Xu, Nan Shi, Yan Zhang, Meizhen Zhao, Kangyong Liu, Mei Zhao, Xiaopan Li. Diagnosis and treatment of patients aged over 65 years with cardiovascular and cerebrovascular comorbidities [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(03): 207-213.
[13]	Wei Rao, Wenfeng Cao, Zhengbing Xiang, Shimin Liu, Yongliang Zhou, An Wen, Lingfeng Wu. Butylphthalide and sodium chloride injection in intravenous thrombolytic therapy of acute cerebral infarction [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(02): 89-93.
[14]	Jingquan Qu, Yang Yu, Jialian Wu, Jian Chen, Junjie Hao. Effect of comprehensive intervention on controlling risk factors in high-risk stroke population in community [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(05): 326-331.
[15]	Zhizhong Yang, Jingnian Ni, Mingqing Wei, Ting Li, Jing Shi, Jinzhou Tian. Research advances on aerobic exercise in the prevention of vascular cognitive impairment [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(05): 299-304.

Please choose a citation manager

Content to export