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中华脑血管病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (04) : 234 -237. doi: 10.11817/j.issn.1673-9248.2020.04.010

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综述

代谢综合征与血管性认知障碍关系的研究进展
韩芸峰1, 来璇2, 杨军1, 马长城1,()   
  1. 1. 100191 北京大学第三医院神经外科
    2. 100191 北京大学第三医院老年内科
  • 收稿日期:2020-01-15 出版日期:2020-08-01
  • 通信作者: 马长城

Advances in the study of metabolic syndrome and vascular cognitive impairment

Yunfeng Han1, Xuan Lai2, Jun Yang1, Changcheng Ma1,()   

  1. 1. Department of Neurosurgery, the Third Hospital, Peking University, Beijing 100191, China
    2. Department of Internal Medicine for the Aged, the Third Hospital, Peking University, Beijing 100191, China
  • Received:2020-01-15 Published:2020-08-01
  • Corresponding author: Changcheng Ma
  • About author:
    Corresponding author: Ma Changcheng, Email:
引用本文:

韩芸峰, 来璇, 杨军, 马长城. 代谢综合征与血管性认知障碍关系的研究进展[J]. 中华脑血管病杂志(电子版), 2020, 14(04): 234-237.

Yunfeng Han, Xuan Lai, Jun Yang, Changcheng Ma. Advances in the study of metabolic syndrome and vascular cognitive impairment[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(04): 234-237.

代谢综合征是以中心性肥胖、糖调节受损或糖尿病、脂代谢紊乱及高血压为主要特征,以胰岛素抵抗为共同病理生理基础,合并出现多种代谢性疾病的临床症候群。血管性认知障碍(VCI)是脑血管病变及其危险因素导致的临床卒中或亚临床血管性脑损伤,涉及至少一个认知域受损的临床综合征。本文将综述代谢综合征与VCI之间的关系,并阐述代谢综合征导致VCI的相关机制。

Metabolic syndrome is a group of clinical syndromes characterized by central obesity, impaired glucose regulation or diabetes, disorder of lipid metabolism and hypertension. Insulin resistance is the common pathophysiological basis of them. Vascular cognitive impairment (VCI) can be present as a clinical stroke or subclinical vascular brain injury, involving at least one cognitive damaged domain. It is caused by cerebrovascular disease and its risk factors. This article reviewed the relationship between metabolic syndrome and VCI, and the mechanism of metabolic syndrome leading to VCI.

1
Skrobot OA, Black SE, Chen C, et al. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study [J]. Alzheimers Dement, 2018, 14(3): 280-292.
2
Satizabal CL, Beiser AS, Chouraki V, et al. Incidence of dementia over three decades in the Framingham Heart Study [J]. N Engl J Med, 2016, 374(6): 523-532.
3
Norton S, Matthews FE, Barnes DE, et al. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data [J]. Lancet Neurol, 2014, 13(8): 788-794.
4
Skrobot OA, O'Brien J, Black S, et al. The vascular impairment of cognition classification consensus study [J]. Alzheimers Dement, 2017, 13(6): 624-633.
5
中国医师协会神经内科分会认知障碍专业委员会编写组. 2019年中国血管性认知障碍诊治指南 [J]. 中华医学杂志, 2019, 99(35): 2737-2744.
6
Jia J, Wang F, Wei C, et al. The prevalence of dementia in urban and rural areas of China [J]. Alzheimers Dement, 2014, 10(1): 1-9.
7
Jia J, Zhou A, Wei C, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese [J]. Alzheimers Dement, 2014, 10(4): 439-447.
8
Sharp SI, Aarsland D, Day S, et al. Hypertension is a potential risk factor for vascular dementia: systematic review [J]. Int J Geriatr Psychiatry, 2011, 26(7): 661-669.
9
Moll VCE, Richard E, Eurelings LS, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial [J]. Lancet, 2016, 388(10046): 797-805.
10
Kavirajan H, Schneider LS. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials [J]. Lancet Neurol, 2007, 6(9): 782-792.
11
Qizilbash N, Gregson J, Johnson ME, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study [J]. Lancet Diabetes Endocrinol, 2015, 3(6): 431-436.
12
Noh HM, Han J, Kim YJ, et al. Sex differences in the relationship between cognitive impairment and overweight or obesity in late life: A 3-year prospective study [J]. Medicine (Baltimore), 2019, 98(9): e14736.
13
Hou Q, Guan Y, Yu W, et al. Associations between obesity and cognitive impairment in the Chinese elderly: an observational study [J]. Clin Interv Aging, 2019, 14: 367-373.
14
Wang F, Zhao M, Han Z, et al. Association of body mass index with amnestic and non-amnestic mild cognitive impairment risk in elderly [J]. BMC Psychiatry, 2017, 17(1): 334.
15
Arnoldussen I, Gustafson DR, Leijsen E, et al. Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC study [J]. Neurology, 2019, 93(9): e864-e878.
16
West NA, Lirette ST, Cannon VA, et al. Adiposity, change in adiposity, and cognitive decline in mid- and late Life [J]. J Am Geriatr Soc, 2017, 65(6): 1282-1288.
17
Zhang T, Yan R, Chen Q, et al. Body mass index, waist-to-hip ratio and cognitive function among Chinese elderly: a cross-sectional study [J]. BMJ Open, 2018, 8(10): e22055.
18
Albanese E, Launer LJ, Egger M, et al. Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies [J]. Alzheimers Dement (Amst), 2017, 8: 165-178.
19
Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease [J]. Int J Mol Sci, 2014, 15(4): 6184-6223.
20
Miller AA, Spencer SJ. Obesity and neuroinflammation: a pathway to cognitive impairment [J]. Brain Behav Immun, 2014, 42: 10-21.
21
Hsieh CC, Chou MJ, Wang CH. Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production [J]. PLoS One, 2017, 12(2): e171969.
22
Elias MF, Goodell AL, Dore GA. Hypertension and cognitive functioning: a perspective in historical context [J]. Hypertension, 2012, 60(2): 260-268.
23
Santisteban MM, Iadecola C. Hypertension, dietary salt and cognitive impairment [J]. J Cereb Blood Flow Metab, 2018, 38(12): 2112-2128.
24
Gottesman RF, Schneider AL, Albert M, et al. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study [J]. JAMA Neurol, 2014, 71(10): 1218-1227.
25
Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J]. Lancet Neurol, 2013, 12(8): 822-838.
26
Huijts M, Duits A, Staals J, et al. Basal ganglia enlarged perivascular spaces are linked to cognitive function in patients with cerebral small vessel disease [J]. Curr Neurovasc Res, 2014, 11(2): 136-141.
27
Benjamin P, Lawrence AJ, Lambert C, et al. Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease [J]. Neuroimage Clin, 2014, 4: 828-837.
28
Zeestraten EA, Lawrence AJ, Lambert C, et al. Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease [J]. Neurology, 2017, 89(18): 1869-1876.
29
Gao Z, Wang W, Wang Z, et al. Cerebral microbleeds are associated with deep white matter hyperintensities, but only in hypertensive patients [J]. PLoS One, 2014, 9(3): e91637.
30
Moroney JT, Tang MX, Berglund L, et al. Low-density lipoprotein cholesterol and the risk of dementia with stroke [J]. JAMA, 1999, 282(3): 254-260.
31
de Oliveira J, Engel DF, de Paula GC, et al. LDL receptor deficiency does not alter brain amyloid-beta levels but causes an exacerbation of apoptosis [J]. J Alzheimers Dis, 2020, 73(2): 585-596.
32
Alzoubi KH, Khabour OF, Salah HA, et al. Vitamin E prevents high-fat high-carbohydrates diet-induced memory impairment: the role of oxidative stress [J]. Physiol Behav, 2013, 119: 72-78.
33
Sawmiller D, Habib A, Hou H, et al. A novel apolipoprotein E antagonist functionally blocks apolipoprotein E interaction with N-terminal amyloid precursor protein, reduces beta-amyloid-associated pathology, and improves cognition [J]. Biol Psychiatry, 2019, 86(3): 208-220.
34
Chuang YF, Hayden KM, Norton MC, et al. Association between APOE epsilon4 allele and vascular dementia: The Cache County study [J]. Dement Geriatr Cogn Disord, 2010, 29(3): 248-253.
35
Han Y, Zhou A, Li F, et al. Apolipoprotein E epsilon4 allele is associated with vascular cognitive impairment no dementia in Chinese population [J]. J Neurol Sci, 2019, 409: 116606.
36
Menezes AR, Lavie CJ, Milani RV, et al. The effects of statins on prevention of stroke and dementia: a review [J]. J Cardiopulm Rehabil Prev, 2012, 32(5): 240-249.
37
Ebady SA, Arami MA, Shafigh MH. Investigation on the relationship between diabetes mellitus type 2 and cognitive impairment [J]. Diabetes Res Clin Pract, 2008, 82(3): 305-309.
38
Neth BJ, Craft S. Insulin resistance and alzheimer's disease: Bioenergetic Linkages [J]. Front Aging Neurosci, 2017, 9: 345.
39
de la Monte SM. Insulin resistance and Alzheimer's disease [J]. BMB Rep, 2009, 42(8): 475-481.
40
Reese LC, Laezza F, Woltjer R, et al. Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-alpha in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease [J]. J Neurochem, 2011, 119(4): 791-804.
41
Li X, Gao Y, Meng Z, et al. Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment [J]. Exp Ther Med, 2016, 11(5): 1993-1998.
42
Jin L, Li YP, Feng Q, et al. Cognitive deficits and Alzheimer-like neuropathological impairments during adolescence in a rat model of type 2 diabetes mellitus [J]. Neural Regen Res, 2018, 13(11): 1995-2004.
43
Murillo OB, Ramirez EJ, Ramos-Rodriguez E, et al. Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes [J]. World J Diabetes, 2016, 7(20): 615-620.
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