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中华脑血管病杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 255 -259. doi: 10.3877/cma.j.issn.1673-9248.2025.03.013

所属专题: 文献

综述

人类免疫缺陷病毒感染患者并发脑出血的研究进展
黄秋慧, 梁志坚()   
  1. 530021 南宁,广西医科大学第一附属医院神经内科
  • 收稿日期:2024-10-15 出版日期:2025-06-01
  • 通信作者: 梁志坚
  • 基金资助:
    国家自然科学基金资助项目(地区科学基金项目)(82260243)

Research advances in intracerebral hemorrhage complicating human immunodeficiency virus infection

Qiuhui Huang, Zhijian Liang()   

  1. Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
  • Received:2024-10-15 Published:2025-06-01
  • Corresponding author: Zhijian Liang
引用本文:

黄秋慧, 梁志坚. 人类免疫缺陷病毒感染患者并发脑出血的研究进展[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(03): 255-259.

Qiuhui Huang, Zhijian Liang. Research advances in intracerebral hemorrhage complicating human immunodeficiency virus infection[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2025, 19(03): 255-259.

随着抗反转录病毒治疗的广泛应用,人类免疫缺陷病毒(HIV)感染者的生存时间显著延长。在此背景下,非传染性并发症,特别是脑出血(ICH),已成为研究者们关注的焦点。现有研究表明,HIV感染与ICH之间存在密切联系,并强调HIV感染者并发ICH时的高死亡风险。因此,本文针对有关HIV感染合并ICH的流行病学研究、病理机制、危险因素、临床表现以及治疗手段的研究进展进行综述。

With the widespread application of antiretroviral therapy, the life expectancy of individuals infected with the human immunodeficiency virus (HIV) has significantly increased. Against this backdrop, non-communicable diseases—particularly intracerebral hemorrhage (ICH)—have emerged as a key focus of research. Current studies indicate a strong association between HIV infection and ICH, highlighting the elevated mortality risk in HIV-infected patients who develop ICH. Therefore, this review synthesizes recent advances in epidemiological trends, pathological mechanisms, risk factors, clinical phenotypes, and therapeutic strategies related to HIV-associated ICH.

1
Pinto AN. AIDS and cerebrovascular disease[J]. Stroke, 1996, 27(3): 538-543.
2
Moawad M, Mohamed Shalaby MM, Hamouda E, et al. Risk of stroke among HIV patients: a systematic review and meta-analysis of global studies and associated comorbidities[J]. J Acquir Immune Defic Syndr, 2024, 95(5): 399-410.
3
Mbonde AA, Chang J, Musubire A, et al. An analysis of stroke risk factors by HIV serostatus in Uganda: implications for stroke prevention in Sub-Saharan Africa[J]. J Stroke Cerebrovasc Dis, 2022, 31(7): 106449.
4
Abdallah A, Chang JL, O'Carroll CB, et al. Validation of the intracerebral hemorrhage score in Uganda[J]. Stroke, 2018, 49(12): 3063-3066.
5
Chow FC, He W, Bacchetti P, et al. Elevated rates of intracerebral hemorrhage in individuals from a US clinical care HIV cohort[J]. Neurology, 2014, 83(19): 1705-1711.
6
Patel UK, Malik P, Li Y, et al. Stroke and HIV-associated neurological complications: a retrospective nationwide study[J]. J Med Virol, 2021, 93(8): 4915-4929.
7
Du M, Wang Y, Qin C, et al. Prevalence and incidence of stroke among people with HIV[J]. AIDS, 2023, 37(11): 1747-1756.
8
Prakash P, Swami Vetha BS, Chakraborty R, et al. HIV-associated hypertension: risks, mechanisms, and knowledge gaps[J]. Circ Res, 2024, 134(11): e150-e175.
9
Durand M, Sheehy O, Baril JG, et al. Risk of spontaneous intracranial hemorrhage in HIV-infected individuals: a population-based cohort study[J]. J Stroke Cerebrovasc Dis, 2013, 22(7): e34-41.
10
Peng J, Wang H, Rong X, et al. Cerebral hemorrhage and alcohol exposure: a review[J]. Alcohol Alcohol, 2020, 55(1): 20-27.
11
Diener HC, Hankey GJ. Primary and secondary prevention of ischemic stroke and cerebral hemorrhage: JACC focus seminar[J]. J Am Coll Cardiol, 2020, 75(15): 1804-1818.
12
Chow FC, Ma Y, Manion M, et al. Factors associated with worse cerebrovascular function in aging women with and at risk for HIV[J]. AIDS, 2021, 35(2): 257-266.
13
Chow FC, Nance RM, Becker K, et al. Sex differences in the risk of stroke associated with traditional and non-traditional factors in a US cohort of people with HIV infection[J]. Neurology, 2024, 103(4): e209726.
14
Feinstein MJ, Hsue PY, Benjamin LA, et al. Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association[J]. Circulation, 2019, 140(2): e98-e124.
15
Hsue PY, Waters DD. HIV infection and coronary heart disease: mechanisms and management[J]. Nat Rev Cardiol, 2019, 16(12): 745-759.
16
Ruamtawee W, Tipayamongkholgul M, Aimyong N, et al. Prevalence and risk factors of cardiovascular disease among people living with HIV in the Asia-Pacific region: a systematic review[J]. BMC Public Health, 2023, 23(1): 477.
17
Mokoena H, Mabhida SE, Choshi J, et al. Endothelial dysfunction and cardiovascular diseases in people living with HIV on specific highly active antiretroviral therapy regimen: a systematic review of clinical studies[J]. Atheroscler Plus, 2024, 55: 47-54.
18
Ku HC, Wu YL, Yip HT, et al. Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case-control study[J]. BMC Infect Dis, 2023, 23(1): 636.
19
Castillo-Mancilla JR, Cavassini M, Schneider MP, et al. Association of incomplete adherence to antiretroviral therapy with cardiovascular events and mortality in virologically suppressed persons with HIV: the Swiss HIV cohort study[J]. Open Forum Infect Dis, 2021, 8(2): ofab032.
20
Chow FC, Li Y, Hu Y, et al. Relationship between HIV infection, antiretroviral therapy, inflammatory markers, and cerebrovascular endothelial function among adults in Urban China[J]. J Acquir Immune Defic Syndr, 2017, 74(3): 339-346.
21
Benjamin LA, Corbett EL, Connor MD, et al. HIV, antiretroviral treatment, hypertension, and stroke in Malawian adults: a case-control study[J]. Neurology, 2016, 86(4): 324-333.
22
Zimba S, Nutakki A, Chishimba L, et al. Risk factors and outcomes of HIV-associated stroke in Zambia[J]. AIDS, 2021, 35(13): 2149-2155.
23
Global Burden of Disease Cancer C, Fitzmaurice C, Abate D, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study[J]. JAMA Oncol, 2019, 5(12): 1749-1768.
24
Sadiq E, Katzew S, Nel J, et al. Stroke, HIV and the immune reconstitution inflammatory syndrome in the absence of opportunistic infections[J]. J Neurol Sci, 2024, 457: 122880.
25
Weber M, Duran Ramirez JJ, Hentzien M, et al. Time trends in causes of death in people with HIV: insights from the Swiss HIV cohort study[J]. Clin Infect Dis, 2024, 79(1): 177-188.
26
Suligoi B, Virdone S, Taborelli M, et al. Excess mortality related to circulatory system diseases and diabetes mellitus among Italian AIDS patients vs. non-AIDS population: a population-based cohort study using the multiple causes-of-death approach[J]. BMC Infect Dis, 2018, 18(1): 428.
27
Cruse B, Cysique LA, Markus R, et al. Cerebrovascular disease in HIV-infected individuals in the era of highly active antiretroviral therapy[J]. J Neurovirol, 2012, 18(4): 264-276.
28
Sugiyama K, Watanuki H, Tochii M, et al. Impact of postoperative cerebral complications in acute infective endocarditis: a retrospective single-center study[J]. J Cardiothorac Surg, 2024, 19(1): 254.
29
Hauer L, Pikija S, Schulte EC, et al. Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review[J]. J Neuroinflammation, 2019, 16(1): 19.
30
Hu Z, Deng X, Zhou S, et al. Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasm[J]. Fluids Barriers CNS, 2023, 20(1): 81.
31
Vinikoor MJ, Napravnik S, Floris-Moore M, et al. Incidence and clinical features of cerebrovascular disease among HIV-infected adults in the Southeastern United States[J]. AIDS Res Hum Retroviruses, 2013, 29(7): 1068-1074.
32
Hatleberg CI, Ryom L, Kamara D, et al. D: A: D Study Group. Predictors of ischemic and hemorrhagic strokes among people living with HIV: the D: A: D International Prospective Multicohort Study[J]. EClinicalMedicine, 2019, 13: 91-100.
33
Hernandez Fustes OJ, Arteaga Rodriguez C. Neurological manifestations of acquired immunodeficiency syndrome[J]. Cureus, 2020, 12(9): e10449.
34
Thakur KT, Lyons JL, Smith BR, et al. Stroke in HIV-infected African Americans: a retrospective cohort study[J]. J Neurovirol, 2016, 22(1): 50-55.
35
Theofilis P, Vordoni A, Koukoulaki M, et al. Overview of infections as an etiologic factor and complication in patients with vasculitides[J]. Rheumatol Int, 2022, 42(5): 759-770.
36
Vega LE, Espinoza LR. Vasculitides in HIV infection[J]. Curr Rheumatol Rep, 2020, 22(10): 60.
37
Gutierrez J, Ortiz G. HIV/AIDS patients with HIV vasculopathy and VZV vasculitis: a case series[J]. Clin Neuroradiol, 2011, 21(3): 145-151.
38
Takayama M, Kashiwagi M, Matsusue A, et al. An autopsy case of cerebral hemorrhage in an HIV-infected patient with suspected HIV-associated cerebrovascular disease[J]. J Forensic Leg Med, 2024, 103: 102672.
39
Ferfar Y, Savey L, Comarmond C, et al. Large-vessel vasculitis in human immunodeficiency virus-infected patients[J]. J Vasc Surg, 2018, 67(5): 1501-1511.
40
Chetty R, Batitang S, Nair R. Large artery vasculopathy in HIV-positive patients: another vasculitic enigma[J]. Hum Pathol, 2000, 31(3): 374-379.
41
Saadoun D, Vautier M, Cacoub P. Medium- and large-vessel vasculitis[J]. Circulation, 2021, 143(3): 267-282.
42
White EI, Anand P, Cervantes-Arslanian AM. Characteristics and evolution of cerebral aneurysms among adults living with HIV: a retrospective, longitudinal case series[J]. J Stroke Cerebrovasc Dis, 2023, 32(6): 107127.
43
Filipkowski AM, Kundu S, Eden SK, et al. Association of HIV infection and incident abdominal aortic aneurysm among 143 001 veterans[J]. Circulation, 2023, 148(2): 135-143.
44
Gutierrez J, Elkind MS, Petito C, et al. The contribution of HIV infection to intracranial arterial remodeling: a pilot study[J]. Neuropathology, 2013, 33(3): 256-263.
45
Benjamin L, Khoo S. HIV infection and stroke[J]. Handb Clin Neurol, 2018, 152: 187-200.
46
Roquer J, Palomeras E, Knobel H, et al. Intracerebral haemorrhage in AIDS[J]. Cerebrovasc Dis, 1998, 8(4): 222-227.
47
Kucab P, Bhattacharya P. Epidemiology of acquired immune deficiency syndrome and cerebrovascular disease in a post antiretroviral era[J]. J Stroke Cerebrovasc Dis, 2017, 26(6): 1197-1203.
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