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中华脑血管病杂志(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 209 -214. doi: 10.3877/cma.j.issn.1673-9248.2026.02.014

综述

铁死亡在中医药治疗缺血性脑卒中中的研究进展
马吉辰1,2, 王少松2, 王雪飞2, 姫旭2, 刘桂林2,()   
  1. 1 061108 河北沧州,北京中医药大学东方学院
    2 100010 北京,首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室
  • 收稿日期:2026-02-04 出版日期:2026-04-01
  • 通信作者: 刘桂林
  • 基金资助:
    国家卫生健康委能力建设和继续教育中心慢病管理研究课题(GWJJMB202510021149); 首都医科大学附属北京中医医院中医药学科建设项目

Research progress on the mechanisms of ferroptosis in traditional Chinese medicine treatment of ischemic stroke

Jichen Ma1,2, Shaosong Wang2, Xuefei Wang2, Xu Ji2, Guilin Liu2,()   

  1. 1 Beijing University of Chinese Medicine Oriental College, Cangzhou 061108, China
    2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University; Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China
  • Received:2026-02-04 Published:2026-04-01
  • Corresponding author: Guilin Liu
引用本文:

马吉辰, 王少松, 王雪飞, 姫旭, 刘桂林. 铁死亡在中医药治疗缺血性脑卒中中的研究进展[J/OL]. 中华脑血管病杂志(电子版), 2026, 20(02): 209-214.

Jichen Ma, Shaosong Wang, Xuefei Wang, Xu Ji, Guilin Liu. Research progress on the mechanisms of ferroptosis in traditional Chinese medicine treatment of ischemic stroke[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2026, 20(02): 209-214.

铁死亡是一种以铁依赖性脂质过氧化蓄积为特征的程序性细胞死亡方式,在缺血性脑卒中(IS)及脑缺血再灌注损伤的发生和发展中发挥重要作用。中医药通过调控铁代谢失衡、脂质过氧化异常蓄积及抗氧化防御系统等关键环节干预铁死亡过程,从而发挥神经保护作用。本文对铁死亡在IS中的主要机制及中医药干预研究进展进行综述,以期为IS的防治提供新的研究思路。

Ferroptosis is a type of programmed cell death characterized by iron-dependent lipid peroxidation accumulation, playing a significant role in the development of ischemic stroke (IS) and cerebral ischemia-reperfusion injury. Traditional Chinese medicine can intervene in the ferroptosis process by regulating key mechanisms such as iron metabolism imbalance, abnormal lipid peroxidation accumulation, and the antioxidant defense system, thereby exerting neuroprotective effects. This article reviews the primary mechanisms of ferroptosis in IS and the research progress of traditional Chinese medicine interventions, aiming to provide new research insights for the prevention and treatment of IS.

图1 中医药调控铁死亡治疗缺血性脑卒中的作用机制 注:BBB为血脑屏障;TFR1为转铁蛋白受体1;Fpn1为铁蛋白转运蛋白1;FTH1为铁蛋白重链1;System Xc-为胱氨酸/谷氨酸反向转运体;Nrf2为核因子E2相关因子2;GPX4为谷胱甘肽过氧化物酶4;SLC7A11为溶质载体家族7成员11;PUFA为多不饱和脂肪酸;ACSL4为长链脂酰辅酶A合成酶4;PUFA-PL为多不饱和脂肪酸磷脂;LPCAT3为溶血磷脂酰胆碱酰基转移酶3;ROS为活性氧;Cystine为胱氨酸;Cysteine为半胱氨酸;GSH为谷胱甘肽;MDA为丙二醛;4-HNE为4-羟基壬烯醛;NIHSS为美国国立卫生研究院卒中量表
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