Application of multimodal magnetic resonance technologies in white matter lesion related cognitive impairment

doi:10.11817/j.issn.1673-9248.2021.05.002

Abstract

Abstract:

White matter lesion (WML) is a common imaging characteristic of cerebral small vessel disease, which is closely related to cognitive impairment (CI) and is an important risk factor for stroke and dementia. The rapid development of neuroimaging has led to a deeper understanding of the age-related cognitive decline and dementia in WML. In recent years, multimodal magnetic resonance technologies have been used to explore the potential mechanism of WML related CI, which may provide further insights into the structural and functional changes caused by WML. This article reviews the application progress in multimodal magnetic resonance in WML related CI.

Key words: White matter lesion, Cognitive impairment, Neuroimaging, Multimodal magnetic resonance technologies, Mechanism

Dan Yang, Yun Xu. Application of multimodal magnetic resonance technologies in white matter lesion related cognitive impairment[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2021, 15(05): 281-286.

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References 57

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MRI技术	应用范围	观察指标	主要研究发现
sMRI	可对脑组织进行形态学分析，提取皮层形态学、WML体积等信息	灰质厚度、表面积、体积；WML体积	WML与区域灰质萎缩相关，且能通过导致灰质萎缩导致认知障碍
rs-MRI	通过检测脑组织内血氧饱和度及血流量，间接反映神经元的活动情况	低频振幅、局部一致性、功能连接	rs-fMRI相关检测指标与WML相关认知障碍密切相关且能有效识别WML相关的认知障碍
DTI	能够检测到水分子随机运动的大小和方向，早期脑白质纤维束的微结构改变	平均弥散率、各项异性分数	WML可能是白质微结构改变病程的最终阶段，DTI能早期发现白质微结构改变，可准确预测WMH相关的认知障碍
DCE-MRI	可提供组织内微血管的重要功能信息，发现脑组织低灌注区，正确评估局部血流的动力学变化	血脑屏障渗透率、脑血流量、平均通过时间	血脑屏障渗透率的增加与WML负荷和WML相关的认知下降相关
MRS	测定活体内某一特定组织区域的化学成分和神经代谢水平，用于识别脑组织的代谢变化	总肌酸、NAA含量，NAA/肌酸比值	MRS检测的神经组织的总肌酸和NAA含量以及NAA/肌酸比值与WML体积和认知障碍相关

MRI技术	应用范围	观察指标	主要研究发现
sMRI	可对脑组织进行形态学分析，提取皮层形态学、WML体积等信息	灰质厚度、表面积、体积；WML体积	WML与区域灰质萎缩相关，且能通过导致灰质萎缩导致认知障碍
rs-MRI	通过检测脑组织内血氧饱和度及血流量，间接反映神经元的活动情况	低频振幅、局部一致性、功能连接	rs-fMRI相关检测指标与WML相关认知障碍密切相关且能有效识别WML相关的认知障碍
DTI	能够检测到水分子随机运动的大小和方向，早期脑白质纤维束的微结构改变	平均弥散率、各项异性分数	WML可能是白质微结构改变病程的最终阶段，DTI能早期发现白质微结构改变，可准确预测WMH相关的认知障碍
DCE-MRI	可提供组织内微血管的重要功能信息，发现脑组织低灌注区，正确评估局部血流的动力学变化	血脑屏障渗透率、脑血流量、平均通过时间	血脑屏障渗透率的增加与WML负荷和WML相关的认知下降相关
MRS	测定活体内某一特定组织区域的化学成分和神经代谢水平，用于识别脑组织的代谢变化	总肌酸、NAA含量，NAA/肌酸比值	MRS检测的神经组织的总肌酸和NAA含量以及NAA/肌酸比值与WML体积和认知障碍相关

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