Research progress in exosomes, miRNA carried by exosome, and stroke

doi:10.11817/j.issn.1673-9248.2021.06.012

Abstract

Abstract:

Exosomes are special vesicles secreted by different kinds of cells, which can carry a variety of substances including microRNA (miRNA) and proteins, participating in intercellular signal communication. Stroke is a complex cerebrovascular disease, characterized by high mortality and high disability. Currently, there is a lack of specific biomarkers to assess the severity of damage and progression caused by stroke. At the same time, medicine treatment for stroke is not satisfying, with considerable side effects. Exosomes play an important role in stroke and afterwards neural repair, showing potential diagnostic, monitoring and therapeutic application . Here, we review the role of exosomes and exosome-derived miRNA in ischemic stroke and hemorrhagic stroke in order to enlighten the diagnosis, monitoring and treatment of stroke.

Key words: Exosomes, microRNA, Stroke, Neuroprotection, Therapy vectors

Mengjie Wang, Song Feng, Wenyuan Ma, Chao Chen, Feng Jin. Research progress in exosomes, miRNA carried by exosome, and stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2021, 15(06): 418-421.

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