Stroke is one of the leading causes of mortality and disability in China. Facing the challenge of stroke, China Stroke Prevention Project Committee (CSPPC) was established in April 2011 under the leading of the Ministry of Health. The CSPPC actively promotes and stroke prevention and control in China. In 2021, CSPPC has obtained remarkable achievements as following: high-risk stroke population screening and the relevant intervention, construction of stroke centers, promotion of appropriate stroke treatment technologies, tiered diagnosis and treatment of stroke, and health education. In 2022, CSPPC will mainly carry out the following tasks: strengthening the construction of stroke centers and promote regional collaboration; strengthening appropriate technical training to improve the effectiveness of stroke treatment; carrying out high-quality screening of high-risk stroke populations; continuing to popularize health knowledge; perfroming follow up of patients with stroke and improving the health education in general population.