Short-term clinical efficacy of Edaravone Dexborneol for patients with acute anterior circulatory ischemic stroke

doi:10.11817/j.issn.1673-9248.2022.04.007

Abstract

Abstract:

Objective

To observe the short-term clinical effect of Edaravone Dexborneol injection for acute anterior circulatory ischemic stroke.

Methods

A retrospective study of 80 patients with acute anterior circulatory ischemic stroke admitted to the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from August to December 2020 without intravenous thrombolysis or endovascular treatment was conducted. The observation group (32 cases) was treated with conventional treatment combining Edaravone Dexborneol injection, while the control group (48 cases) was treated with only conventional treatment. Both groups were treated for 14 days. Independent sample t-test was used to compare the National Institute of Health stroke scale (NIHSS) scores at admission, 7 14 days after treatment. The total efficacy of the two groups on 7 and 14 days after treatment was compared by chi-square test.

Results

No statistically significant difference was observed in NIHSS scores of the two groups at baseline before treatment (P＞0.05). NIHSS score of the observation group on 7 and 14 days after treatment were lower than those of the control group [(6.31±4.81) vs (8.48±4.77); (4.40±2.95) vs (6.56±4.27)], and the differences were statistically significant (t=-2.167, P=0.033; t=-2.485, P=0.015). The total efficacy of the observation group on 7 and 14 days after treatment were higher than those of the control group (90.63% vs 70.83%; 96.88% vs 77.08%), and the differences were statistically significant (χ²=4.494, P=0.034; χ²=5.899, P=0.015).

Conclusion

Edaravone Dexborneol injection was effective in short time for acute anterior circulatory ischemic brain injury.

Key words: Acute ischemic stroke, Neuroprotectant, Edaravone Dexborneol

Liao Wu, Ying Sun, Xiaoyu Ni, Guihua Ni. Short-term clinical efficacy of Edaravone Dexborneol for patients with acute anterior circulatory ischemic stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(04): 253-257.

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https://zhnxgbzz.cma-cmc.com.cn/EN/Y2022/V16/I04/253

Figures/Tables 3

项目	观察组（n=32）	对照组（n=48）	统计值	P值
年龄（岁， $x ¯$ ±s）	65.66±10.15	67.60±8.95	t=-0.904	0.369
女性［例（%）］	11（34.38）	15（31.25）	χ²=0.085	0.770
高血压［例（%）］	20（62.50）	33（68.75）	χ²=0.335	0.562
糖尿病［例（%）］	8（25.00）	13（27.08）	χ²=0.043	0.836
高脂血症［例（%）］	15（46.88）	18（37.50）	χ²=0.696	0.404
心房颤动［例（%）］	7（21.88）	5（10.42）	χ²=1.977	0.160
吸烟［例（%）］	19（59.38）	28（58.33）	χ²=0.009	0.926
饮酒［例（%）］	13（40.63）	14（29.17）	χ²=1.127	0.288
既往脑卒中史［例（%）］	6（18.75）	7（14.58）	χ²=0.245	0.621
发病时间（h， $x ¯$ ±s）	33.53±19.09	32.15±18.36	t=0.326	0.746
基线NIHSS评分（分， $x ¯$ ±s）	12.16±4.81	11.88±4.31	t=0.273	0.786

项目	观察组（n=32）	对照组（n=48）	统计值	P值
年龄（岁， $x ¯$ ±s）	65.66±10.15	67.60±8.95	t=-0.904	0.369
女性［例（%）］	11（34.38）	15（31.25）	χ²=0.085	0.770
高血压［例（%）］	20（62.50）	33（68.75）	χ²=0.335	0.562
糖尿病［例（%）］	8（25.00）	13（27.08）	χ²=0.043	0.836
高脂血症［例（%）］	15（46.88）	18（37.50）	χ²=0.696	0.404
心房颤动［例（%）］	7（21.88）	5（10.42）	χ²=1.977	0.160
吸烟［例（%）］	19（59.38）	28（58.33）	χ²=0.009	0.926
饮酒［例（%）］	13（40.63）	14（29.17）	χ²=1.127	0.288
既往脑卒中史［例（%）］	6（18.75）	7（14.58）	χ²=0.245	0.621
发病时间（h， $x ¯$ ±s）	33.53±19.09	32.15±18.36	t=0.326	0.746
基线NIHSS评分（分， $x ¯$ ±s）	12.16±4.81	11.88±4.31	t=0.273	0.786

组别	例数	治疗后7 d	治疗后14 d
观察组	32	6.31±3.71	4.40±2.95
对照组	48	8.48±4.77	6.56±4.27
t值		-2.167	-2.485
P值		0.033	0.015

组别	例数	显效		有效		无效		总有效率
组别	例数	7 d	14 d	7 d	14 d	7 d	14 d	7 d	14 d
观察组	32	5（15.63）	9（28.13）	24（75.00）	22（68.75）	3（9.37）	1（3.12）	29（90.63）	31（96.88）
对照组	48	6（12.50）	7（14.58）	28（58.33）	30（62.50）	14（29.17）	11（22.92）	34（70.83）	37（77.08）
χ²值								4.494	5.899
P值								0.034	0.015

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