Research progress in the disease-modifing therapy of cerebral amyloid angiopathy

doi:10.11817/j.issn.1673-9248.2024.04.014

Abstract

Abstract:

The mechanism of cerebral amyloid angiopathy (CAA) has not been fully elucidated. The imbalance between the production and clearance of amyloid β (Aβ) leads to the deposition of Aβ and subsequent oxidative stress and inflammatory responses, which are key factors in the destruction of the vascular wall. Current treatments for CAA focus on the preventing and providing symptomatic treatment of hemorrhages while there has been no substantial progress in disease-modifying therapies to prevent disease progression. Based on the possible pathogenesis of CAA, several potential therapeutic targets have been identified that could improve prognosis and clinical outcomes, including reducing Aβ production, immune-mediated Aβ clearance, increasing physiological Aβ clearance, and anti-oxidation and anti-inflammatory measures. Some targets are supported by clinical research evidence, while most research remains still in the preclinical stage. Further basic and clinical research on disease-modifying therapies for CAA is of significant clinical importance.

Key words: Cerebral amyloid angiopathy, Disease-modifying therapy, Amyloid β, Mechanism

Juanjuan Wu, Bin Peng, Jun Ni. Research progress in the disease-modifing therapy of cerebral amyloid angiopathy[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(04): 375-381.

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