Association between adverse drug reactions by cerebrovascular drugs and the gender, age of patients

doi:10.3877/cma.j.issn.1673-9248.2014.02.005

Abstract

Abstract:

Objective

To investigate the use of adverse reactions in patients with cerebrovascular drugs occurred gender and age relationship.

Methods

Using cerebrovascular drugs in our hospital from March 2012 to March 2014 after the adverse reactions in patients selected 200 patients were analyzed retrospectively, including 128 cases of male (64%), 72 cases were female (36%). 60 years of age or older in 117 patients (58.50%), < 60 years old in 83 patients (41.50%), the data analysis on the adverse reaction.

Results

The occurrence rate of adverse reactions of male patients was higher than that of control group, with significant difference (P < 0.05), different ages of patients with adverse reactions of different, 50~59 years old and 60~69 years old age in two patients occurred adverse reaction rate are the highest, with significant difference (P < 0.05).

Conclusions

Cerebrovascular drugs can cause a lot of adverse reactions, and adverse reaction occurred in the age and gender of patients have a greater relationship.

Key words: Cerebral vascular disease, Drug therapy, Adverse reaction

Guangxing Yue. Association between adverse drug reactions by cerebrovascular drugs and the gender, age of patients[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2014, 08(02): 15-17.

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Figures/Tables 2

References 15

1	高扬，孟莉，姜德春，等．我院1463例药品不良反应报告分析[J].中国药业，2013,22(14):91-92.
2	李芳，王峥，成静，等．老年患者服用小剂量肠溶阿司匹林的不良反应和有效性分析[J]．中华老年心脑血管病杂志,2012,14(1):38-40.
3	冯慧玲，杨冠涛．阿司匹林联合缓释型双嘧达莫防治急性缺血性卒中后脑血管缺血事件的临床评价[J].实用预防医学，2012,19(11):1689-1690.
4	黄红艳．抗高血压药物的不良反应与应对措施[J]．求医问药（学术版）,2012,10(11):1012.
5	谢贵波．心脑血管类中药注射剂的不良反应分析[J]．医学信息，2013,(23):178-178.
6	商培培，于海涛．血塞通临床应用及中药注射剂不良反应的探讨[J].健康必读（中旬刊）,2012,11(5):258-258.
7	丰倩．普罗布考及阿托伐他汀钙对缺血性脑血管病患者血脂水平影响的研究[D]．河北医科大学，2012.
8	张瑞淑，张遥,闫荟，等．他汀类药物的不良反应研究进展[J]．中国循证心血管医学杂志，2013,(5):547-549.
9	陈佳力，袁越平.缬沙坦单药与缬沙坦联合苯磺酸氨氯地平对高血压患者的疗效分析[J]．实用药物与临床，2014,17(3):273-275.
10	陈爱玲．调查分析西药和中成药联合使用的不良反应[J]．健康之路，2014,(5):349.
11	孙丽静，白丽华，赵惠，等．血管紧张素转换酶抑制剂的不良反应及处理对策[J]．临床合理用药杂志，2014,7(7):95-96.
12	李建珍．我院心脑血管类中药注射剂的不良反应分析[J]．海峡药学，2013,25(6):284-285.
13	桂皓辉，樊艾雯，刘波，等．探究抗高血压药物的不良反应及预防措施[J]．中国保健营养（中旬刊）,2014,24(2):673.
14	胡慧，郭秀妍，邵梅英，等．两种药物对高压氧治疗时患者不良反应影响的比较[J].护士进修杂志，2013,28(5):467-469.
15	张琦，乌宇波，曹曰针，等．HLA-B*5801等位基因与别嘌呤醇药物引起严重不良反应关联性的Meta分析[J]．中国输血杂志，2013,26(9):829-831.

组别	例数	皮疹	头晕	咳嗽	头痛	呕吐	过敏样反应
男性组	128	44(34.38)	38(29.69)	29(22.66)	19(14.84)	20(27.78)	17(13.28)
女性组	72	15(20.83)	12(16.67)	10(13.89)	4(5.56)	9(12.50)	10(13.89)
χ2	?	4.1945	4.0138	3.8912	3.8567	4.3816	0.3781
P	?	0.0376	0.0397	0.0421	0.0456	0.0342	0.7829

组别	例数	皮疹	头晕	咳嗽	头痛	呕吐	过敏样反应
男性组	128	44(34.38)	38(29.69)	29(22.66)	19(14.84)	20(27.78)	17(13.28)
女性组	72	15(20.83)	12(16.67)	10(13.89)	4(5.56)	9(12.50)	10(13.89)
χ2	?	4.1945	4.0138	3.8912	3.8567	4.3816	0.3781
P	?	0.0376	0.0397	0.0421	0.0456	0.0342	0.7829

组别	例数	皮疹	头晕	咳嗽	头痛	呕吐	过敏样反应
>80	19	3(15.79)	4(21.05)	6(31.58)	3(15.79)	2(10.53)	2(10.53)
70～80	30	11(36.67)	14(46.67)	15(50.00)	10(33.33)	8(26.67)	6(20.00)
60～69	68	34(50.00)	36(52.94)	37(54.41)	25(36.76)	21(30.88)	18(26.47)
50～59	48	29(60.42)	30(62.50)	19(39.58)	18(37.50)	16(33.33)	14(29.17)
40～49	25	9(36.00)	8(32.00)	8(16.67)	7(14.58)	5(10.42)	5(10.42)
<40	10	1(10.00)	2(20.00)	2(20.00)	3(30.00)	1(10.00)	1(10.00)

组别	例数	皮疹	头晕	咳嗽	头痛	呕吐	过敏样反应
>80	19	3(15.79)	4(21.05)	6(31.58)	3(15.79)	2(10.53)	2(10.53)
70～80	30	11(36.67)	14(46.67)	15(50.00)	10(33.33)	8(26.67)	6(20.00)
60～69	68	34(50.00)	36(52.94)	37(54.41)	25(36.76)	21(30.88)	18(26.47)
50～59	48	29(60.42)	30(62.50)	19(39.58)	18(37.50)	16(33.33)	14(29.17)
40～49	25	9(36.00)	8(32.00)	8(16.67)	7(14.58)	5(10.42)	5(10.42)
<40	10	1(10.00)	2(20.00)	2(20.00)	3(30.00)	1(10.00)	1(10.00)

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