Abstract:

Objective

To analyze the predictive value of serum microribonucleic acid-130a（miR-130a） expression and admission Glasgow coma scale （GCS） score for the hematoma enlargement elderly patients with hypertensive intracerebral hemorrhage （ICH）.

Methods

A total of 208 elderly patients with hypertensive ICH admitted to the 966th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from March 2019 to September 2021 were enrolled as the disease group. This group was divided into an enlarged hematoma subgroup （35 cases） and an unexpanded hematoma subgroup（173 cases） based on the occurrence of hematoma enlargement. Additionally, 180 healthy elderly individuals who underwent routine health examinations at our hospital during the same period were enrolled as the control group. Real-time fluorescence quantitative polymerase chain reaction （RT-qPCR） was used to detect serum miR-130a expression levels in all participants； Logistic regression analysis was used to identify the influencing factors of brain hematoma enlargement in the disease group, and the receiver operating characteristic （ROC） curve was drawn to analyze its diagnostic value for brain hematoma enlargement.

Results

Statistically significant differences were observed among the enlarged hematoma group, nonenlarged hematoma group, and control group in terms of systolic blood pressure （SBP） at admission,diastolic blood pressure （DBP） at admission, and the prevalence of hypertension ［（154.29±17.93） mmHg vs （152.34±20.93） mmHg vs （142.74±18.52） mmHg, F=12.540, P＜0.001； （93.67±12.72） mmHg vs（92.80±10.74） mmHg vs （84.55±10.18） mmHg, F=29.930, P＜0.001； 22 （62.85%） vs 98 （56.65%） vs 63 （35.00%）, χ²=6.327, P＜0.001］. Significant differences were also noted between the enlarged and nonenlarged hematoma groups in GCS score, serum miR-130a expression, and hematoma volume ［（6.09±1.57）vs （7.84±1.63）, （1.99±0.32） vs （1.50±0.28）, and 23.60 （14.30, 36.50） ml vs 15.50 （4.60, 20.80） ml, all P＜0.05］. The incidence of hematoma enlargement in the disease group was 16.83% （35/208）. Logistic regression analysis revealed that admission GCS score and serum miR-130a expression were significant predictors of hematoma enlargement （OR=6.931 and 8.831, respectively； both P＜0.001）. ROC curve analysis showed that serum miR-130a and admission GCS score had AUC values of 0.931 and 0.772, respectively,for predicting hematoma enlargement.

Conclusion

Both elevated serum miR-130a and admission GCS score are valuable predictors of hematoma enlargement in elderly patients with hypertensive ICH.

Key words: Elderly, Hypertensive intracerebral hemorrhage, Microrna-130a, Enlargement of cerebral hematoma