Research advances in the association between intercellular adhesion molecule-1 and stroke

doi:10.3877/cma.j.issn.1673-9248.2025.03.011

Abstract

Abstract:

Intercellular adhesion molecule-1 (ICAM-1), a member of the immunoglobulin superfamily, is widely expressed on the surfaces of vascular endothelial cells and is recognized as one of the most sensitive biomarkers in vascular pathology. Extensive studies have demonstrate a close relationship between ICAM-1 and the occurrence, progression, treatment, and prognosis of stroke. This review synthesizes recent global research on the interactions between ICAM-1 and stroke, summarizes the regulatory roles and mechanisms of ICAM-1 in disease progression, and elaborates on its potential therapeutic targets and clinical applications. The findings aim to provide new insights for stroke prevention and treatment strategies.

Key words: Intercellular adhesion molecule-1, Ischemic stroke, Hemorrhagic stroke

Fen Ma, Baoai Wang. Research advances in the association between intercellular adhesion molecule-1 and stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2025, 19(03): 244-249.

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研究干预	研究对象	作用靶点	结论	参考文献
miR-223-3P抗体	SAH小鼠模型	NF-κB/ICAM-1	NF-κB/ICAM-1通路被抑制，ICAM-1表达明显降低，使得小鼠模型的受损神经功能得以改善	[44]
CAY10444（S1P3拮抗剂）	ACH大鼠模型	S1P-CCL2-p-p38 MAPK	大鼠血清ICAM-1水平低表达，脑水肿体积减小，行为缺陷得到改善，血脑屏障破坏减弱	[46]
S1P CAY10444	体外人脑微血管内皮细胞	S1P-CCL2-p-p38 MAPK	给予S1P刺激可以观察到ICAM-1表达水平显著增加，反之给予S1P抑制后ICAM-1表达降低	[46]
普罗布考片	MCAO小鼠模型	S1P-CCL2-p-p38 MAPK	可减少梗死面积和血管渗漏，保持紧密连接蛋白的完整性	[47]
冰片修饰丹参酮ⅡA脂质体	缺血性脑卒中大鼠模型	NF-kB/ICAM-1	降低细胞NF-kB/ICAM-1通路相关蛋白表达的水平，抑制血清ICAM-1的表达，阻断缺血早期白细胞和内皮细胞的黏附过程，增加血流量	[48]
依达拉奉右莰醇注射液	CI动物模型	TLR4/NF-κB	可降低TLR4/NF-κB蛋白的表达水平，使ICAM-1低表达，缩小梗死损伤面积，降低再灌注损伤程度	[49]
芪参益气滴丸	MCAO大鼠模型	迷迭香	逆转了MCAO大鼠血清ICAM-1的高表达，大鼠神经功能、自发活动、步态及空间记忆等方面得到明显改善	[50]

研究干预	研究对象	作用靶点	结论	参考文献
miR-223-3P抗体	SAH小鼠模型	NF-κB/ICAM-1	NF-κB/ICAM-1通路被抑制，ICAM-1表达明显降低，使得小鼠模型的受损神经功能得以改善	[44]
CAY10444（S1P3拮抗剂）	ACH大鼠模型	S1P-CCL2-p-p38 MAPK	大鼠血清ICAM-1水平低表达，脑水肿体积减小，行为缺陷得到改善，血脑屏障破坏减弱	[46]
S1P CAY10444	体外人脑微血管内皮细胞	S1P-CCL2-p-p38 MAPK	给予S1P刺激可以观察到ICAM-1表达水平显著增加，反之给予S1P抑制后ICAM-1表达降低	[46]
普罗布考片	MCAO小鼠模型	S1P-CCL2-p-p38 MAPK	可减少梗死面积和血管渗漏，保持紧密连接蛋白的完整性	[47]
冰片修饰丹参酮ⅡA脂质体	缺血性脑卒中大鼠模型	NF-kB/ICAM-1	降低细胞NF-kB/ICAM-1通路相关蛋白表达的水平，抑制血清ICAM-1的表达，阻断缺血早期白细胞和内皮细胞的黏附过程，增加血流量	[48]
依达拉奉右莰醇注射液	CI动物模型	TLR4/NF-κB	可降低TLR4/NF-κB蛋白的表达水平，使ICAM-1低表达，缩小梗死损伤面积，降低再灌注损伤程度	[49]
芪参益气滴丸	MCAO大鼠模型	迷迭香	逆转了MCAO大鼠血清ICAM-1的高表达，大鼠神经功能、自发活动、步态及空间记忆等方面得到明显改善	[50]

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