Advances in probing of brain extracellular space and its application in the diagnosis and treatment of cerebrovascular diseases

doi:10.3877/cma.j.issn.1673-9248.2025.05.012

Abstract

Abstract:

The brain extracellular space (ECS) is a crucial component of the brain, serving as the immediate environment supporting neuronal survival and function. However, its full significance—particularly in the context of cerebrovascular diseases—remains underexplored and underutilized. This review summarizes recent advances in brain ECS research, highlights current detection techniques, and explores its emerging applications in the diagnosis and treatment of cerebrovascular disorders. Notably, as research in this field deepens, Chinese scientists have begun to investigate innovative approaches, such as utilizing the ECS for drug delivery and enhancing metabolic waste clearance via surgical interventions. These developments offer promising avenues for advancing the management of cerebrovascular diseases in the future.

Key words: Brain extracellular space, Brain interstitial system, Cerebrovascular disease

Yumeng Cheng, Na Yu, Hanbo Tan, Yi Tang, Yu Fu, Yifei Wei, Hongbin Han. Advances in probing of brain extracellular space and its application in the diagnosis and treatment of cerebrovascular diseases[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2025, 19(05): 441-450.

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