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中华脑血管病杂志(电子版) ›› 2023, Vol. 17 ›› Issue (02) : 154 -158. doi: 10.11817/j.issn.1673-9248.2023.02.012

综述

昼夜节律与沉默信息调节因子1在缺血性脑卒中神经保护中的相互作用研究进展
史静1, 郝晨曦1, 何苗1, 李伟荣1,()   
  1. 1. 030009 太原,山西医科大学第九临床医学院(附属太原中心医院)神经内科
  • 收稿日期:2022-08-27 出版日期:2023-04-01
  • 通信作者: 李伟荣
  • 基金资助:
    山西省医学重点科研项目(2021XM14)

Research progress in interaction of circadian rhythm and silent information regulator 1 in neuroprotection against ischemic stroke

Jing Shi1, Chenxi Hao1, Miao He1, Weirong Li1,()   

  1. 1. Department of Neurology, Ninth Clinical Medical College(Affiliated Taiyuan Central Hospital), Shanxi Medical University, Taiyuan 030009, China
  • Received:2022-08-27 Published:2023-04-01
  • Corresponding author: Weirong Li
引用本文:

史静, 郝晨曦, 何苗, 李伟荣. 昼夜节律与沉默信息调节因子1在缺血性脑卒中神经保护中的相互作用研究进展[J/OL]. 中华脑血管病杂志(电子版), 2023, 17(02): 154-158.

Jing Shi, Chenxi Hao, Miao He, Weirong Li. Research progress in interaction of circadian rhythm and silent information regulator 1 in neuroprotection against ischemic stroke[J/OL]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(02): 154-158.

缺血性脑卒中的发生率和致死率多在清晨达到高峰,这种变化提示昼夜节律紊乱与急性缺血性脑卒中密切相关。虽然有研究认为,清晨血压升高(所谓的晨峰)、血小板聚集增加以及内皮功能的钝化与清晨缺血性脑卒中的发生相关,但其分子机制在很大程度上是未知的。近期研究发现,去乙酰酶沉默信息调节因子1(SIRT1)参与生物钟基因转录的调控过程。并且,SIRT1通过去乙酰化作用来抑制氧化应激、炎性反应、自噬及细胞凋亡等,在缺血性脑卒中的发生发展及治疗中发挥重要作用。因此,探讨昼夜节律和SIRT1之间的复杂关联以及他们在调节缺血性脑卒中神经保护中的相互作用非常必要。控制和定时管理SIRT1及生物钟蛋白或可成为缺血性脑卒中防治的新靶点。

The incidence and the mortality of ischemic stroke mostly peak in the early morning. This phenomenon suggests that circadian rhythm disorder is closely related to acute ischemic stroke. Although some studies believe that the rise of blood pressure (the so-called morning peak), the increase of platelet aggregation, and the passivation of endothelial function are related to the occurrence of early morning ischemic stroke, its molecular mechanism is largely unknown. Recent studies have found that deacetylase silent information regulator 1 (SIRT1) is involved in regulating clock gene transcription. Moreover, SIRT1 plays an important role in the occurrence, development and treatment of ischemic stroke by deacetylation to inhibit oxidative stress, inflammatory response, autophagy, and apoptosis. Therefore, it is necessary to explore the complex association between circadian rhythm and SIRT1 and their interaction in regulating neuroprotection against ischemic stroke.

图1 生物钟基因的反馈途径 注:CLOCK为昼夜节律运动输出周期故障蛋白;BMAL1为脑和肌肉组织芳香烃受体核转运蛋白的类似蛋白1;Per为阻遏蛋白;Cry为隐花色素蛋白;RORE为视黄酸相关孤儿受体反应元件;ROR为类视黄醇相关孤儿受体;Rev为内源性反转录病毒
图2 沉默信息调节因子1介导的去乙酰化作用 注:NAD+为烟酰胺腺嘌呤二核苷酸
图3 SIRT1通过CLOCK/BMAL1复合物的去乙酰化调控转录过程 注:CLOCK为昼夜节律运动输出周期故障蛋白;BMAL1为脑和肌肉组织芳香烃受体核转运蛋白的类似蛋白1;Per为阻遏蛋白;Cry为隐花色素蛋白;NAD+为烟酰胺腺嘌呤二核苷酸,SIRT1为沉默信息调节因子1,Nucleus为细胞核,ER为内质网
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