Spontaneous intracerebral hemorrhage is a serious neurological disease with high morbidity and mortality, which is often accompanied by catastrophic outcomes such as death and disability. Although great progress has been made in microsurgical techniques for the treatment of primary brain injury after intracerebral hemorrhage, little progress has been made in the treatment of inflammatory cascade reaction and secondary brain injury after intracerebral hemorrhage. On the other hand, the results of many preclinical studies have shown that many types of inflammatory cells, including microglia, astrocytes and T lymphocytes, play a major role in neuroinflammation and secondary brain injury. These inflammatory cells and their specific mechanisms also provide new potential targets for the treatment of intracerebral hemorrhage. At present, a variety of drugs have shown the preliminary effect of reducing nerve inflammation and ameliorating secondary brain injury in animal models of cerebral hemorrhage and early-stage clinical trials. This article summarizes the mechanism of neuroinflammation involved in secondary brain injury after intracerebral hemorrhage and several drugs with clinical translational potential, in order to provide reference for researchers.