Prevalence of cerebral small vessel diseases in peritoneal dialysis patients

doi:10.11817/j.issn.1673-9248.2021.04.007

Abstract

Abstract:

Objective

To investigate the prevalence of cerebral small vessel disease (CSVD) in peritoneal dialysis patients.

Methods

We consecutively included 22 patients with renal failure due to various reasons who regularly consulted the peritoneal dialysis clinic in Peking University Third Hospital from 2016.3 to 2016.9. Demographic and clinical data were prospectively collected, magnetic resonance imaging of brain (T2* included) was done. Evaluation of neuroimaging and grading the relevant scales was completed.

Results

There were 3 patients (13.6%) with acute small subcortical infarction, 8 patients (36.4%) with lacune, 13 patients (59.1%) with enlarged perivascular spaces, 21 patients (95.5%) with white matter hyperintensities, 10 patients (45.5%) with cerebral microbleeds among the 22 included patients. More diabetes mellitus was found in patients with lower CSVD burden (＜2). Patients with stroke or dyslipidemia presents significant longer dialysis time (P＜0.05). No significant effect was found between patients with or without hypertension or cardiovascular disease (P＞0.05).

Conclusion

There is a high prevalence of CVSD in peritoneal dialysis patients, we should pay more attention on it.

Key words: Peritoneal dialysis, Cerebral small vessel disease, Cerebral microbleeds, Stroke

Danyang Tian, Wen Tang, Dongsheng Fan. Prevalence of cerebral small vessel diseases in peritoneal dialysis patients[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2021, 15(04): 232-236.

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URL: https://zhnxgbzz.cma-cmc.com.cn/EN/10.11817/j.issn.1673-9248.2021.04.007

https://zhnxgbzz.cma-cmc.com.cn/EN/Y2021/V15/I04/232

Figures/Tables 4

患者编号	脑微出血总数	脑叶（个）	深部（个）	幕下（个）
1	10	4	0	6
2	6	6	0	0
3	1	1	0	0
4	1	0	1	0
5	1	1	0	0
6	5	2	3	0
7	1	0	0	1
8	32	14	15	3
9	1	0	1	0
10	1	1	0	0

指标	CSVD总负荷＜2（n=16）	CSVD总负荷≥2（n=6）	检验值	P值
年龄（ $x ¯$ ±s，岁）	55.4±14.3	60.8±5.9	t=-0.90	0.38
性别（男性/女性，例）	10/6	3/3	χ²=3.80	0.43
透析时间（ $x ¯$ ±s，月）	43.8±48.5	53.7±37.4	t=-0.45	0.66
高血压[例（%）]	15（93.8）	5（16.7）	χ²=0.28	0.46
糖尿病[例（%）]	9（56.3）	0（0）	χ²=6.30	0.02
脂代谢紊乱[例（%）]	9（56.3）	3（50.0）	χ²=0.18	1.00
卒中史[例（%）]	2（12.5）	0（0）	χ²=0.88	1.00
冠心病[例（%）]	1（6.3）	2（33.3）	χ²=2.49	0.18
房颤[例（%）]	0（0）	0（0）	—	—

指标	CSVD总负荷＜2（n=16）	CSVD总负荷≥2（n=6）	检验值	P值
年龄（ $x ¯$ ±s，岁）	55.4±14.3	60.8±5.9	t=-0.90	0.38
性别（男性/女性，例）	10/6	3/3	χ²=3.80	0.43
透析时间（ $x ¯$ ±s，月）	43.8±48.5	53.7±37.4	t=-0.45	0.66
高血压[例（%）]	15（93.8）	5（16.7）	χ²=0.28	0.46
糖尿病[例（%）]	9（56.3）	0（0）	χ²=6.30	0.02
脂代谢紊乱[例（%）]	9（56.3）	3（50.0）	χ²=0.18	1.00
卒中史[例（%）]	2（12.5）	0（0）	χ²=0.88	1.00
冠心病[例（%）]	1（6.3）	2（33.3）	χ²=2.49	0.18
房颤[例（%）]	0（0）	0（0）	—	—

疾病	例数	透析时间	t值	P值
高血压			-1.02	0.32
有	20	49.6±46.2
无	2	15.5±9.2
糖尿病			-0.98	0.34
有	9	57.8±45.1
无	13	28.7±45.2
脂代谢紊乱			-2.27	0.04
有	12	64.7±45.7
无	10	24.7±35.0
卒中史			-2.34	0.03
有	2	40.1±38.9
无	20	111.0±69.3
冠心病			0.72	0.72
有	3	37.3±28.8
无	19	48.0±47.6

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