Research progress in risk factors of hemorrhage transformation after intravenous thrombolysis in acute ischemic stroke

doi:10.11817/j.issn.1673-9248.2023.01.002

Abstract

Abstract:

Acute ischemic stroke is one of the most common diseases in the emergency department. It is characterized by a high fatality rate and high disability rate. In acute ischemic stroke, intravenous thrombolysis is used widely as a first-line treatment. Hemorrhagic transformation is one of the common complications after thrombolysis, and the main risk factors include age, body temperature, hypertension, etc. Currently, based on the risk factors of hemorrhagic transformation after thrombolysis, there are mainly six foreign models of risk warning, including iScore model, SEDAN model, THRIVE model, SITS model, STARTING-SICH model, and SICH SCORE model; and three domestic models, including THRIVE-c model, model of Xu team, and model of Chang Hong team. As a clinician, it is particularly imperative to recognize the relevant risk factors of hemorrhagic transformation after thrombolysis. This review mainly focuses on the recent progress in the risk factors of hemorrhagic transformation after thrombolysis.

Key words: Acute ischemic stroke, Intravenous thrombolysis, Hemorrhage transformation

Xin Li, Jianzhong Yang. Research progress in risk factors of hemorrhage transformation after intravenous thrombolysis in acute ischemic stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(01): 9-15.

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分类	分型	描述
1		梗死脑组织的出血转化
1a	HI1	散在斑点状，无占位效应
1b	HI2	融合的斑点状，无占位效应
1c	PH1	梗死组织内的血肿＜30%，无实质性的占位效应
2		梗死脑组织内部或超出梗死组织的脑出血
	PH2	血肿占梗死组织的30%或以上，占位效应明显
3		梗死脑组织外的脑出血或颅外出血
3a		远离梗死脑组织的实质性血肿
3b		脑室内出血
3c		蜘蛛膜下腔出血
3d		硬膜下出血

分类	分型	描述
1		梗死脑组织的出血转化
1a	HI1	散在斑点状，无占位效应
1b	HI2	融合的斑点状，无占位效应
1c	PH1	梗死组织内的血肿＜30%，无实质性的占位效应
2		梗死脑组织内部或超出梗死组织的脑出血
	PH2	血肿占梗死组织的30%或以上，占位效应明显
3		梗死脑组织外的脑出血或颅外出血
3a		远离梗死脑组织的实质性血肿
3b		脑室内出血
3c		蜘蛛膜下腔出血
3d		硬膜下出血

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