Value of 8-iso-PGF2α and P selectin in evaluating cognitive function of patients with cerebral small vessel disease

doi:10.11817/j.issn.1673-9248.2023.04.010

Abstract

Abstract:

Objective

To explore the value of 8-iso-PGF2α and P selectin in evaluating cognitive function of patients with cerebral small vessel disease.

Methods

99 patients with cerebrovascular disease admitted to Wuwei Cancer Hospital of Gansu Province from September 2018 to August 2021 were included as the case group, and 50 healthy individuals who received physical examinations during the same period were included as the control group. 8-iso-PGF2α and P-selectin levels were determined by enzyme-linked immunosorbent assay, and were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between 8-iso-PGF2α, P-selectin level, and MoCA scores. The patients in the case group were divided into cognitive impairment subgroup (n=42) and non-cognitive impairment subgroup (n=57) according to the results of diffusion tensor imaging, and the predictive value of 8-iso-PGF2α and P-selectin on cognitive dysfunction in patients with cerebrovascular disease was analyzed by receiver operating characteristic curve (ROC).

Results

(1) Serum 8-iso-PGF2α and P selectin level of patients in the case group were significantly higher than those in the control group, and the differences between groups were statistically significant [(220.69±50.16) pg/ml vs (95.13±16.59) pg/ml, t=17.206, P＜0.001; (80.49±12.56) μg/L vs (13.59±6.98) μg/L, t=34.995, P＜0.001]; (2) Pearson correlation analysis showed that, there was a negative correlation between serum 8-iso-PGF2α, P-selectin level and MoCA score of patients in the case group (r=-0.4840, P＜0.0001; r=-0.4216, P＜0.0001); (3) Serum 8-iso-PGF2α and P selectin level of patients with cognitive impairment subgroup were significantly higher than those of non-cognitive impairment subgroup [(245.21±23.56) pg/ml vs (198.52±20.56) pg/ml, t=10.277, P＜0.001; (92.01±10.45) μg/L vs (79.89±9.68) μg/L, t=5.883, P＜0.001], and MoCA score was significantly lower than that of non-cognitive impairment subgroup [(24.51±1.98) scores vs (27.16±2.12) scores, t=6.320, P＜0.001], and the differences between groups were statistically significant; (4) the AUC of 8-iso-PGF2α, P-selectin in predicting cognitive impairment of cerebrovascular disease was 0.8200 (P=0.0156) and 0.8000 (P=0.0233).

Conclusion

8-iso-PGF2α and P-selectin have certain application value in the evaluation of cognitive function of patients with cerebral small vessel disease.

Key words: 8 isomeric prostaglandins, P selectin, Cerebral small vessel disease, Cognitive impairment, Predicted value

Daohe Wang, Yuanyuan Shi. Value of 8-iso-PGF2α and P selectin in evaluating cognitive function of patients with cerebral small vessel disease[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(04): 364-368.

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Figures/Tables 6

组别	例数	男/女[例（%）]	年龄（岁， $x ¯$ ±s）	吸烟[例（%）]	饮酒[例（%）]	高血压[例（%）]
病例组	99	61（61.6）/38（38.4）	68.98±6.51	39（39.4）	42（42.4）	45（45.5）
对照组	50	26（52.0）/24（48.0）	69.89±6.99	15（30.0）	23（46.0）	23（46.0）
统计值		χ²=1.264	t=0.786	χ²=1.269	χ²=0.173	χ²=0.004
P值		0.261	0.433	0.260	0.678	0.950

组别	例数	男/女[例（%）]	年龄（岁， $x ¯$ ±s）	吸烟[例（%）]	饮酒[例（%）]	高血压[例（%）]
病例组	99	61（61.6）/38（38.4）	68.98±6.51	39（39.4）	42（42.4）	45（45.5）
对照组	50	26（52.0）/24（48.0）	69.89±6.99	15（30.0）	23（46.0）	23（46.0）
统计值		χ²=1.264	t=0.786	χ²=1.269	χ²=0.173	χ²=0.004
P值		0.261	0.433	0.260	0.678	0.950

组别	例数	8-iso-PGF2α（pg/ml）	P选择素（μg/L）
病例组	99	220.69±50.16	80.49±12.56
对照组	50	95.13±16.59	13.59±6.98
t值		17.206	34.995
P值		＜0.001	＜0.001

组别	例数	8-iso-PGF2α（pg/ml）	P选择素（μg/L）	MoCA评分（分）
认知障碍亚组	57	245.21±23.56	92.01±10.45	24.51±1.98
非认知障碍亚组	42	198.52±20.56	79.89±9.68	27.16±2.12
t值		10.277	5.883	6.320
P值		＜0.001	＜0.001	＜0.001

检测指标	敏感度（%）	特异度（%）	AUC	95% CI	SE	P值	截断值
8-iso-PGF2α	90.48	87.72	0.9628	0.9319~0.9937	0.0158	＜0.0001	223.80
P选择素	83.33	73.68	0.8321	0.7517~0.9125	0.0410	＜0.0001	87.37

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