Advances in the application of cerebral microcirculation imaging technology in cerebral small vessel disease

doi:10.11817/j.issn.1673-9248.2024.03.015

Abstract

Abstract:

Cerebral small vessel disease (CSVD) is a prevalent cause of stroke and vascular dementia, particularly in the elderly population. In CSVD, a series of pathophysiological changes of blood vessels lead to microcirculation disorders. A deeper understanding of the morphological changes and hemodynamic regulation of microcirculation is helpful for the diagnosis, treatment and monitoring of CSVD. This paper introduces the relationship between the regulation of cerebral microcirculation and CSVD, as well as the novel techniques applied in cerebral microcirculation imaging at present, to offer insights that could enhance clinical monitoring of cerebral microcirculation in CSVD.

Key words: Cerebral microcirculation, Cerebral small vessel disease, Ultrasound super-resolution imaging, Photoacoustic imaging

Mengxin Wang, Mofan Li, Shumin Wang. Advances in the application of cerebral microcirculation imaging technology in cerebral small vessel disease[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(03): 281-284.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhnxgbzz.cma-cmc.com.cn/EN/10.11817/j.issn.1673-9248.2024.03.015

https://zhnxgbzz.cma-cmc.com.cn/EN/Y2024/V18/I03/281

References 34

1	胡文立, 杨磊, 李譞婷, 等. 中国脑小血管病诊治专家共识2021 [J]. 中国卒中杂志, 2021, 16(7): 716-726.
2	黄勇华, 赵弘轶. 脑小血管病的现状和展望 [J/OL]. 中华脑血管病杂志(电子版), 2020, 14(1): 33-36.
3	Geranmayeh MH, Rahbarghazi R, Farhoudi M. Targeting pericytes for neurovascular regeneration [J]. Cell Commun Signal, 2019, 17(1): 26.
4	Grubb S, Lauritzen M, Aalkjær C. Brain capillary pericytes and neurovascular coupling [J]. Comp Biochem Physiol A Mol Integr Physiol, 2021, 254: 110893.
5	Zambach SA, Cai C, Helms HCC, et al. Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion [J]. Proc Natl Acad Sci U S A, 2021, 118(26): e2023749118.
6	Cai C, Fordsmann JC, Jensen SH, et al. Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses [J]. Proc Natl Acad Sci U S A, 2018, 115(25): e5796-e5804.
7	Rungta RL, Chaigneau E, Osmanski BF, et al. Vascular compartmentalization of functional hyperemia from the synapse to the pia [J]. Neuron, 2018, 99(2): 362-375.
8	Chow BW, Nuñez V, Kaplan L, et al. Caveolae in CNS arterioles mediate neurovascular coupling [J]. Nature, 2020, 579(7797): 106-110.
9	Goedicke-Fritz S, Kaistha A, Kacik M, et al. Evidence for functional and dynamic microcompartmentation of Cav-1/TRPV4/K(Ca) in caveolae of endothelial cells [J]. Eur J Cell Biol, 2015, 94(7-9): 391-400.
10	Sperti M, Arba F, Acerbi A, et al. Determinants of cerebral collateral circulation in acute ischemic stroke due to large vessel occlusion [J]. Front Neurol, 2023, 14: 1181001.
11	Liu L, Guo M, Lv X, et al. Role of transient receptor potential vanilloid 4 in vascular function [J]. Front Mol Biosci, 2021, 8: 677661.
12	Hainsworth AH, Markus HS, Schneider JA. Cerebral small vessel disease, hypertension, and vascular contributions to cognitive impairment and dementia [J]. Hypertension, 2024, 81(1): 75-86.
13	Jiang S, Wu S, Zhang S, et al. Advances in understanding the pathogenesis of lacunar stroke: from pathology and pathophysiology to neuroimaging [J]. Cerebrovasc Dis, 2021, 50(5): 588-596.
14	Staehr C, Giblin JT, Gutiérrez-Jiménez E, et al. Neurovascular uncoupling is linked to microcirculatory dysfunction in regions outside the ischemic core following ischemic stroke [J]. J Am Heart Assoc, 2023, 12(11): e029527.
15	Zhang D, Ruan J, Peng S, et al. Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling [J]. Nat Neurosci, 2024, 27(2): 232-248.
16	Rüwald JM, Jacobs C, Scheidt S, et al. Laser-based techniques for microcirculatory assessment in orthopedics and trauma surgery: past, present, and future [J]. Ann Surg, 2019, 270(6): 1041-1048.
17	Goldberg J, Miller DR, Dimanche A, et al. Intraoperative laser speckle contrast imaging to assess vessel flow in neurosurgery: a pilot study [J]. Neurosurgery, 2023. Online ahead of print.
18	Miller DR, Ashour R, Sullender CT, et al. Continuous blood flow visualization with laser speckle contrast imaging during neurovascular surgery [J]. Neurophotonics, 2022, 9(2): 021908.
19	Chen Q, Song H, Yu J, et al. Current development and applications of super-resolution ultrasound imaging [J]. Sensors (Basel), 2021, 21(7): 2417.
20	Errico C, Pierre J, Pezet S, et al. Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging [J]. Nature, 2015, 527(7579): 499-502.
21	Lowerison MR, Sekaran NVC, Zhang W, et al. Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse [J]. Sci Rep, 2022, 12(1): 619.
22	Bourquin C, Poree J, Lesage F, et al. In vivo pulsatility measurement of cerebral microcirculation in rodents using dynamic ultrasound localization microscopy [J]. IEEE Trans Med Imaging, 2022, 41(4): 782-792.
23	Soulioti DE, Espindola D, Dayton PA, et al. Super-resolution imaging through the human skull [J]. IEEE Trans Ultrason Ferroelectr Freq Control, 2020, 67(1): 25-36.
24	Demené C, Robin J, Dizeux A, et al. Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients [J]. Nat Biomed Eng, 2021, 5(3): 219-228.
25	Favre H, Pernot M, Tanter M, et al. Boosting transducer matrix sensitivity for 3D large field ultrasound localization microscopy using a multi-lens diffracting layer: a simulation study [J]. Phys Med Biol, 2022, 67(8): 085009.
26	Favre H, Pernot M, Tanter M, et al. Transcranial 3D ultrasound localization microscopy using a large element matrix array with a multi-lens diffracting layer: anin vitrostudy [J]. Phys Med Biol, 2023, 68(7): 075003.
27	Demeulenaere O, Bertolo A, Pezet S, et al. In vivo whole brain microvascular imaging in mice using transcranial 3D ultrasound localization microscopy [J]. EBioMedicine, 2022, 79: 103995.
28	Van Sloun RJG, Solomon O, Bruce M, et al. Super-resolution ultrasound localization microscopy through deep learning [J]. IEEE Trans Med Imaging, 2021, 40(3): 829-839.
29	Yan J, Zhang T, Broughton-Venner J, et al. Super-resolution ultrasound through sparsity-based deconvolution and multi-feature tracking [J]. IEEE Trans Med Imaging, 2022, 41(8): 1938-1947.
30	Ma H, Yang Y, Gao M, et al. A novel rat model of cerebral small vessel disease and evaluation by super-resolution ultrasound imaging [J]. J Neurosci Methods, 2022, 379: 109673.
31	Dong B, Yao J, Deán-Ben XL. Editorial: advances in photoacoustic neuroimaging [J]. Front Neurosci, 2022, 16: 859515.
32	Steinberg I, Huland DM, Vermesh O, et al. Photoacoustic clinical imaging [J]. Photoacoustics, 2019, 14: 77-98.
33	Zhu B, Li H, Xie C, et al. Photoacoustic microscopic imaging of cerebral vessels for intensive monitoring of metabolic acidosis [J]. Mol Imaging Biol, 2023, 25(4): 659-670.
34	Zhong X, Liang Y, Wang X, et al. Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope [J]. Light Sci Appl, 2024, 13(1): 5.

[1]	Siqing Ma, Qiang Chen, Ying Xu, Xiujuan Yan, Juanli Liu. Screening target and signal pathway regulating cerebral microcirculation of the Tibetan medicine Rhodiola based on data mining and network topology [J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 08(04): 353-359.
[2]	Xuan Zhang, Ming Feng, Qian Wang, Rong Xue. Effect of Shunaoxin Dropping Pills on objective sleep parameters and inflammatory markers in patients with cerebral small vessel disease [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2024, 14(03): 140-145.
[3]	Wenxuan Chang, Ting Wang, Wei Liu, Tianqi Lan, Jing Peng, Shiyao Wang, Xiaopeng Zhang, Chen Feng, Xuemei Gong, Min Zhu. Research progress of executive dysfunction caused by cerebral small vessel disease [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(03): 179-182.
[4]	Qian Gao, Xiaofang Li, Yazhao Yang, Jing Zhang, Lei Cui, Liqing Yang, Yanmin Xia. Progress in understanding of role of thyroid hormone and Apelin in cognitive impairment caused by cerebral small vessel disease [J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(02): 201-206.
[5]	Jie Shen, Hongyang Xie, Cuiqiao Xia, Yonghua Huang. Progress in the research of cognitive frailty in cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(02): 181-184.
[6]	Wenhua Ding, Yuwei Wang, Jingjing Qiu, Qiong Yang, Yurong Geng. Research progress on imaging biomarkers and motor dysfunction in cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 429-434.
[7]	Meijuan Yan, Lihui Shao. Correlation between lipoprotein (a) and arteriosclerotic cerebral small vessel disease in elderly population without diabetes, hyperlipidemia and hypertension [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(05): 458-463.
[8]	Lin Liu, Qishan Zhang, Manqian Liao, Yurong Chen, Bei Li, Yucheng He, Shengtao Tang. HTRA1-related autosomal dominant cerebral small vessel disease: a family report and literature review [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(04): 379-385.
[9]	Daohe Wang, Yuanyuan Shi. Value of 8-iso-PGF2α and P selectin in evaluating cognitive function of patients with cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(04): 364-368.
[10]	Hongmei Hu, Wenli Hu. Research progress in total burden assessment scale for cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(02): 145-149.
[11]	Zhuoran Li, Wenli Hu. Association of biomarkers of endothelial function, inflammation, and neurodegenerative diseases with arteriosclerotic cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(01): 57-60.
[12]	Xingwen Zhang, Lei Hou, Ye Ran, Chenglin Tian. Clinical analysis of acute multiple ischemic manifestation of cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(01): 22-25.
[13]	Xin Liu, Lijuan Wang, Ying Liu, Shuang Wang, Shaohong Xu, Xiaogang Li. Risk factors and Cognitive training effect of varying degrees of post-stroke cognitive impairment [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(05): 314-319.
[14]	Xi Yan, Junkui Shang, Fengyu Wang, Xiaoming Qin, Xuejing Huo, Ruijie Liu, Jinlong Zou, Jiewen Zhang. Association between homocysteine, coagulation-fibrinolysis parameters and cerebral small vessel disease [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(01): 27-31.
[15]	Hongmei Hu, Wenli Hu. Research progress in common etiology and imaging features of cerebral microbleeds with different spatial distribution [J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2022, 16(01): 8-11.

Please choose a citation manager

Content to export