Research progress on the relationship between mitochondrial dysfunction and cardiovascular disease, ischemic stroke and chronic kidney disease

doi:10.11817/j.issn.1673-9248.2024.01.010

Abstract

Abstract:

Cardiovascular disease (CVD), ischemic stroke (IS), and chronic kidney disease (CKD) are common clinical diseases with high all-cause mortality and poor prognosis. Mitochondria, as the power plant of cells, is the key to ensuring the integrity and vitality of cells. Previous studies have shown that mitochondrial dysfunction is closely related to cardiovascular diseases, cerebrovascular diseases, and kidney diseases. Therefore maintaining mitochondrial homeostasis is a promising strategy for treating CVD, IS, and CKD. This review summarized the malfunction of mitochondrial homeostasis (mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy) and its relationship with CVD, IS, and CKD, in order to explore novel therapeutic strategies for CVD, IS, and CKD.

Key words: Mitochondrial dysfunction, Cardiovascular disease, Ischemic stroke, Chronic kidney disease

Ting Luo, Lingzhi Qiu, Dong Yi, Hua Yan. Research progress on the relationship between mitochondrial dysfunction and cardiovascular disease, ischemic stroke and chronic kidney disease[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(01): 60-63.

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