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Chinese Journal of Cerebrovascular Diseases(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (04): 274-279. doi: 10.3877/cma.j.issn.1673-9248.2025.04.002

• Expert Forum • Previous Articles    

Mechanism and research progress of lactic acid and lactylation in ischemic stroke

Hongmei Qiao, Jingfen Zhang(), Baojun Wang   

  1. Department of Neurology, Baotou Central Hospital, Baotou 014040, China
  • Received:2025-02-01 Online:2025-08-01 Published:2025-09-29
  • Contact: Jingfen Zhang

Abstract:

Lactate serves not only an important energy metabolite in the nervous system but also participates in the regulation of cellular functions. Under conditions of hypoxia or increased neuronal activity, astrocytes generate lactate through glycolysis, providing energy support to neurons via the lactate shuttle mechanism. Stroke-induced ischemia and hypoxia significantly elevate lactate levels. Lactate not only contributes to energy metabolism but also influences lactylation modifications and functions as a signaling molecule in cellular regulation. This article reviews the alterations in lactate metabolism and lactylation during ischemic stroke and their impacts on neuroprotection and recovery, offering new insights and strategies for clinical treatment of stroke.

Key words: Lactate, Lactation, Astrocytes, Stroke

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