切换至 "中华医学电子期刊资源库"

中华脑血管病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (04) : 199 -203. doi: 10.11817/j.issn.1673-9248.2020.04.003

所属专题: 专家论坛 文献

专家论坛

大气污染与缺血性脑卒中相关性的研究进展
李中中1, 布凯林1, 秦晋1, 张荣2, 刘晓云3,()   
  1. 1. 050000 石家庄,河北医科大学第二医院神经内科
    2. 050000 石家庄,河北医科大学公共卫生学院卫生毒理教研室
    3. 050000 石家庄,河北医科大学第二医院神经内科;050000 石家庄,河北省神经病学重点实验室;050000 石家庄,河北医科大学医学健康研究神经中心
  • 收稿日期:2020-03-29 出版日期:2020-08-01
  • 通信作者: 刘晓云
  • 基金资助:
    国家自然科学基金项目(81571160)

Research progress on the association between air pollution and cerebral ischemic strokes

Zhongzhong Li1, Kailin Bu1, Jin Qin1, rong Zhang2, Xiaoyun Liu3()   

  1. 1. Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    2. Department of Toxicology, the School of Health, Hebei Medical University, Shijiazhuang 050000, China
    3. Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;Key Laboratory of Neurology in Hebei, Shijiazhuang 050000, China;Neuroscience Research Center, Medicine and Health Institute, Hebei Medical University, Shijiazhuang 050000, China
  • Received:2020-03-29 Published:2020-08-01
  • Corresponding author: Xiaoyun Liu
  • About author:
    Corresponding author: Liu Xiaoyun, Email:
引用本文:

李中中, 布凯林, 秦晋, 张荣, 刘晓云. 大气污染与缺血性脑卒中相关性的研究进展[J]. 中华脑血管病杂志(电子版), 2020, 14(04): 199-203.

Zhongzhong Li, Kailin Bu, Jin Qin, rong Zhang, Xiaoyun Liu. Research progress on the association between air pollution and cerebral ischemic strokes[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(04): 199-203.

缺血性脑卒中发病率逐年攀升,伴随而来的是高病死率和高致残率。缺血性脑卒中发病率的升高与人口老龄化、饮食结构改变、气候及环境等多种因素有关。目前越来越多的学者认为大气污染是缺血性脑卒中发生的重要危险因素,但在缺血性脑卒中发生发展的过程中,大气污染与其相关的机制尚未达成统一共识。深入了解大气污染对缺血性脑卒中的影响及其相关机制有助于缺血性脑卒中的预防,促进缺血性脑卒中后神经功能的恢复,改善患者预后。因此,本文对近年来大气污染与缺血性脑卒中相关性及其机制进行了综述。

The incidence of cerebral ischemic strokes is annually increasing, with higher and higher mortality and disability. The increasing morbidity of cerebral ischemic strokes is due to various factors such as population aging, changes in diet, climate and environment. At present, more and more researchers believe that the air pollution is an important risk factor for cerebral ischemic strokes. However, the underlying mechanisms between cerebral ischemic strokes and air pollution haven't reached a consensus yet. In-depth understanding of effect of the air pollution on cerebral ischemic strokes and its related mechanisms can help to prevent cerebral ischemic stroke, restore neurological function, and improve the prognosis of patients with cerebral ischemic strokes. Therefore, we reviewed the correlation between air pollution and cerebral ischemic strokes in recent years.

1
2017 DALYs GBD and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [J]. Lancet, 2018, 10159(392): 1859-1922.
2
WHO. Burden of disease from ambient air pollution for 2012: World Health Organization [Z]. 2014-5-12.

URL    
3
Wu Z, Zhang Y, Zhang L, et al. Trends of outdoor air pollution and the impact on premature mortality in the Pearl River Delta region of southern China during 2006–2015 [J]. Sci Total Environ, 2019, 690: 248-260.
4
Ai S, Wang C, Qian ZM, et al. Hourly associations between ambient air pollution and emergency ambulance calls in one central Chinese city: Implications for hourly air quality standards [J]. Sci Total Environ, 2019, 696: 133956.
5
Johannson KA, Balmes JR, Collard HR. Air Pollution Exposure: Novel Environmental Risk Factor for Interstitial Lung Disease? [J]. Chest, 2015, 147(4): 1161-1167.
6
魏明山, 丰红林. PM2.5与脑卒中的研究 [J]. 脑与神经病杂志, 2018, 26(3): 195-198.
7
Huang K, Liang F, Yang X, et al. Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project [J]. BMJ, 2019, 367: l6720.
8
Oʼdonnell MJ, Fang J, Mittleman MA, et al. Fine Particulate Air Pollution (PM2.5) and the Risk of Acute Ischemic Stroke [J]. Epidemiology, 2011, 22(3): 422-431.
9
Stafoggia M, Cesaroni G, Peters A, et al. Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events: Results from 11 European Cohorts within the ESCAPE Project [J]. Environ Health Perspec, 2014, 122(9): 919-925.
10
Korek MJ, Bellander TD, Lind T, et al. Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm [J]. J Expo Sci Environ Epidemiol, 2015, 25(5): 517-523.
11
Wellenius GA, Burger MR, Coull BA, et al. Ambient Air Pollution and the Risk of Acute Ischemic Stroke [J]. Arch Intern Med, 2012, 172(3): 229-234.
12
Wing JJ, Adar SD, Sánchez BN, et al. Ethnic differences in ambient air pollution and risk of acute ischemic stroke [J]. Environ Res, 2015, 143(Pt A): 62-67.
13
Henrotin JB, Zeller M, Lorgis L, et al. Evidence of the role of short-term exposure to ozone on ischaemic cerebral and cardiac events: the Dijon Vascular Project (DIVA) [J]. Heart, 2010, 96(24): 1990-1996.
14
Scheers H, Jacobs L, Casas L, et al. Long-Term Exposure to Particulate Matter Air Pollution Is a Risk Factor for Stroke [J]. Stroke, 2015, 46(11): 3058-3066.
15
刘莉, 叶鹏, Desikan A, 等. 尾气和非尾气排放颗粒物的相关成分对脑卒中后长期存活的影响 [J]. 中华高血压杂志, 2017, 25(2): 194.
16
Yitshak Sade M, Novack V, Ifergane G, et al. Air Pollution and Ischemic Stroke Among Young Adults [J]. Stroke, 2015, 46(12): 3348-3353.
17
Chung J, Bang OY, Ahn K, et al. Air Pollution Is Associated With Ischemic Stroke via Cardiogenic Embolism [J]. Stroke, 2017, 1(48): 17-23.
18
Caso V, Paciaroni M, Agnelli G, et al. Gender Differences in Patients with Acute Ischemic Stroke [J]. Women's Health, 2010, 6(1): 51-57.
19
Vidale S, Bonanomi A, Guidotti M, et al. Air pollution positively correlates with daily stroke admission and in hospital mortality: a study in the urban area of Como, Italy [J]. Neurol Sci, 2010, 2(31): 179-182.
20
Xiang H, Mertz KJ, Arena VC, et al. Estimation of Short-Term Effects of Air Pollution on Stroke Hospital Admissions in Wuhan, China [J]. PLoS One, 2013, 4(8): e61168.
21
Tsai S, Goggins WB, Chiu H, et al. Evidence for an Association Between Air Pollution and Daily Stroke Admissions in Kaohsiung, Taiwan [J]. Stroke, 2003, 34(11): 2612-2616.
22
Wang Z, Peng J, Liu P, et al. Association between short-term exposure to air pollution and ischemic stroke onset: a time-stratified case-crossover analysis using a distributed lag nonlinear model in Shenzhen, China [J]. Environ Health, 2020, 19(1): 1.
23
Liu H, Tian Y, Xu Y, et al. Association between ambient air pollution and hospitalization for ischemic and hemorrhagic stroke in China: A multicity case-crossover study [J]. Environ Pollut, 2017, 230: 234-241.
24
Yang W, Wang X, Deng Q, et al. An evidence-based appraisal of global association between air pollution and risk of stroke [J]. Int J Cardiol, 2014, 2(175): 307-313.
25
Oudin A, Strömberg U, Jakobsson K, et al. Estimation of Short-Term Effects of Air Pollution on Stroke Hospital Admissions in Southern Sweden [J]. Neuroepidemiology, 2010, 34(3): 131-142.
26
Sang N, Yun Y, Li H, et al. SO2 Inhalation Contributes to the Development and Progression of Ischemic Stroke in the Brain [J]. Toxicol Sci, 2010, 2(114): 226-236.
27
Zhu N, Li H, Han M, et al. Environmental nitrogen dioxide (NO2) exposure influences development and progression of ischemic stroke [J]. Toxicol Lett, 2012, 214(2): 120-130.
28
Hong YC, Lee JT, Kim H, et al. Air pollution: a new risk factor in ischemic stroke mortality [J]. Stroke, 2002, 9(33): 2165-2169.
29
Yu Y, Dong H, Yao S, et al. Protective Effects of Ambient Ozone on Incidence and Outcomes of Ischemic Stroke in Changzhou, China: A Time-Series Study [J]. Int J Environ Res Public Health, 2017, 12(14): 1610.
30
Sancak EB, Turkön H, çukur S, et al. Major Ozonated Autohemotherapy Preconditioning Ameliorates Kidney Ischemia-Reperfusion Injury [J]. Inflammation, 2016, 39(1): 209-217.
31
Chin MT. Basic mechanisms for adverse cardiovascular events associated with air pollution [J]. Heart, 2015, 101(4): 253-256.
32
Rich DQ, Kipen HM, Huang W, et al. Association Between Changes in Air Pollution Levels During the Beijing Olympics and Biomarkers of Inflammation and Thrombosis in Healthy Young Adults [J]. JAMA, 2012, 307(19): 2068-2078.
33
Nemmar A, Zia S, Subramaniyan D, et al. Exacerbation of thrombotic events by diesel exhaust particle in mouse model of hypertension [J]. Toxicology, 2011, 1-2(285): 39-45.
34
Shah AS, Lee KK, Mcallister DA, et al. Short term exposure to air pollution and stroke: systematic review and meta-analysis [J]. BMJ, 2015, 350: h1295.
35
Leung JWC, Chung SSM, Chung SK. Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion [J]. Brain Res, 2009, 1266: 121-129.
36
Thomson EM, Kumarathasan P, Calderón-Garcidueñas L, et al. Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression [J]. Environ Res, 2007, 105(2): 224-233.
37
Link MS, Luttmann-Gibson H, Schwartz J, et al. Acute Exposure to Air Pollution Triggers Atrial Fibrillation [J]. J Am Coll Cardiol, 2013, 62(9): 816-825.
38
Brook RD, Sun Z, Brook JR, et al. Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance: The Air Pollution and Cardiometabolic Disease Study [J]. Hypertension, 2016, 1(67): 77-85.
[1] 赵子祯, 严紫娟, 王家传. 脑类器官培养技术进展及其在缺血性脑卒中损伤修复中的应用[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(02): 121-128.
[2] 尚慧娟, 袁晓冬. 机械取栓术后应用依达拉奉右崁醇对急性缺血性脑卒中预后的改善[J]. 中华神经创伤外科电子杂志, 2023, 09(05): 295-301.
[3] 任香凝, 郑晓明. 缺血性脑卒中与外周免疫应答的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(03): 175-179.
[4] 隆昱洲, 柳华, 张云茜, 李兴统, 范云虎, 尚正良, 宋镇妤, 罗丽华. 依达拉奉预适应延长急性缺血性脑卒中溶栓时间窗的研究及ROS/TXNIP/NLRP3通路参与机制的探讨[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(02): 65-74.
[5] 徐志嘉, 贾振宇, 赵林波, 刘圣, 施海彬, 曹月洲. 高敏肌钙蛋白T动态变化在晚时间窗内进行血管内治疗的急性缺血性脑卒中患者中的预测价值[J]. 中华介入放射学电子杂志, 2023, 11(01): 42-47.
[6] 张许平, 刘佳成, 张舸, 杜艳姣, 李韶, 商丹丹, 王浩, 李艳, 段智慧. CYP2C19基因多态性联合血栓弹力图指导大动脉粥样硬化型非致残性缺血性脑血管事件患者抗血小板治疗的效果[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 477-481.
[7] 邓颖, 黄山, 胡慧秀, 孙超. 老年缺血性脑卒中患者危险因素聚集情况分析[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 344-349.
[8] 李昕, 李永凯, 江树青, 夏来百提姑·赛买提, 杨建中. 急性缺血性脑卒中静脉溶栓后出血转化相关危险因素分析[J]. 中华脑血管病杂志(电子版), 2023, 17(04): 331-336.
[9] 史静, 郝晨曦, 何苗, 李伟荣. 昼夜节律与沉默信息调节因子1在缺血性脑卒中神经保护中的相互作用研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 154-158.
[10] 王晖, 张淑娟, 周宝华, 杨琼, 罗永梅. 基于卒中单元的缺血性脑卒中静脉溶栓模式的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 150-153.
[11] 邱佳敏, 蒋惠怡, 陶涛. 丹参酮ⅡA治疗急性缺血性脑卒中动物模型效果的Meta分析[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 136-144.
[12] 黎丹丹, 程峙娟, 刘旭, 陈未平, 殷敏, 郭华, 涂江龙. 急性后循环进展性缺血性卒中患者血管内治疗的效果[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 112-123.
[13] 俞刘珍雄, 张康睿, 杨若蕊, 刘学春, 王龙, 吴竹青, 吴君仓. 维生素D水平与接受静脉溶栓治疗的缺血性卒中患者预后的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 94-101.
[14] 张运. 缺血性脑卒中取栓治疗新进展[J]. 中华脑血管病杂志(电子版), 2023, 17(02): 0-.
[15] 李昕, 杨建中. 急性缺血性脑卒中静脉溶栓后出血转化危险因素的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(01): 9-15.
阅读次数
全文


摘要