切换至 "中华医学电子期刊资源库"

中华脑血管病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (03) : 151 -154. doi: 10.11817/j.issn.1673-9248.2020.03.006

所属专题: 文献

论著

动脉自旋标记在急性缺血性脑卒中中的临床应用
颜楚明1, 马青峰2,()   
  1. 1. 100053 北京,首都医科大学宣武医院神经内科
    2. 100053 北京,首都医科大学宣武医院神经内科,100053 北京,首都医科大学宣武医院急诊科
  • 收稿日期:2020-04-24 出版日期:2020-06-01
  • 通信作者: 马青峰
  • 基金资助:
    国家重点研发计划 无创性脑血流灌注功能定量评估系统在急性卒中“绿色通道”中的应用价值研究(2019YFC0120904)

Clinical application of arterial spin labeling in acute ischemic stroke

Chuming Yan1, Qingfeng Ma2,()   

  1. 1. Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China
    2. Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China, Department of Emergency, Xuanwu Hospital Capital Medical University, Beijing 100053, China
  • Received:2020-04-24 Published:2020-06-01
  • Corresponding author: Qingfeng Ma
  • About author:
    Corresponding author: Ma Qingfeng, Email:
引用本文:

颜楚明, 马青峰. 动脉自旋标记在急性缺血性脑卒中中的临床应用[J]. 中华脑血管病杂志(电子版), 2020, 14(03): 151-154.

Chuming Yan, Qingfeng Ma. Clinical application of arterial spin labeling in acute ischemic stroke[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(03): 151-154.

动脉自旋标记(ASL)是一种无创的、不使用造影剂的脑灌注成像技术。通过对缺血半暗带、侧支循环等不同影像学表现的研究,广泛应用于缺血性脑卒中的诊断及预后估计。多延迟ASL在原有技术的基础上进行了改进,使得该技术在脑血管病中得到更加广泛的应用。本文综述了ASL对于急性缺血性脑卒中的诊断价值及临床应用,并着重介绍了多延迟ASL这一新技术。

Arterial Spin Labeling (ASL) is a noninvasive imaging technique without contrast agents. Through different imaging features such as ischemic penumbra and collateral flow, ASL can help to recognize ischemic stroke and predict prognosis. Multi-delay ASL is improved on the basis of the original technique, which makes it more widely used in cerebrovascular diseases. This article reviewed the value of ASL and its clinical application in the diagnosis of acute ischemic stroke, in which the multi-delay ASL is mainly introduced.

1
GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 [J]. Lancet Neurol, 2019, 18(05): 439-458.
2
Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct [J]. N Engl J Med, 2018, 378(01): 11-21.
3
Albers GW, Marks MP, Kemp S, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging [J]. N Engl J Med, 2018, 378(08): 708-718.
4
Detre JA, Leigh JS, Williams DS, et al. Perfusion imaging [J]. Magn Reson Med, 1992, 23(01): 37-45.
5
Bokkers RP, Bremmer JP, van Berckel BN, et al. Arterial spin labeling perfusion MRI at multiple delay times: a correlative study with H(2)(15)O positron emission tomography in patients with symptomatic carotid artery occlusion [J]. J Cereb Blood Flow Metab, 2010, 30(01): 222-229.
6
Wang DJ, Alger JR, Qiao JX, et al. The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced MRI [J]. Stroke, 2012, 43(04): 1018-1024.
7
Bivard A, Krishnamurthy V, Stanwell P, et al. Arterial spin labeling versus bolus-tracking perfusion in hyperacute stroke [J]. Stroke, 2014, 45(01): 127-133.
8
Alsop DC, Detre JA, Golay X, et al. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia [J]. Magn Reson Med, 2015, 73(01): 102-116.
9
Dai W, Fong T, Jones RN, et al. Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort [J]. J Magn Reson Imaging, 2017, 45(02): 472-481.
10
Bokkers RP, Hernandez DA, Merino JG, et al. Whole-brain arterial spin labeling perfusion MRI in patients with acute stroke [J]. Stroke, 2012, 43(05): 1290-1294.
11
Buxton RB, Frank LR, Wong EC, et al. A general kinetic model for quantitative perfusion imaging with arterial spin labeling [J]. Magn Reson Med, 1998, 40(03): 383-396.
12
Petersen ET, Mouridsen K, Golay X. The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study [J]. NeuroImage, 2010, 49(01): 104-113.
13
Wang DJ, Alger JR, Qiao JX, et al. Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke-Comparison with dynamic susceptibility contrast enhanced perfusion imaging [J]. Neuroimage Clin, 2013, 03(01): 1-7.
14
Nael K, Meshksar A, Liebeskind DS, et al. Quantitative analysis of hypoperfusion in acute stroke: arterial spin labeling versus dynamic susceptibility contrast [J]. Stroke, 2013, 44(11): 3090-3096.
15
Huang YC, Liu HL, Lee JD, et al. Comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MRI in patients with acute stroke [J]. PloS One, 2013, 08(07): e69085.
16
Zaharchuk G, El Mogy IS, Fischbein NJ, et al. Comparison of arterial spin labeling and bolus perfusion-weighted imaging for detecting mismatch in acute stroke [J]. Stroke, 2012, 43(07): 1843-1848.
17
Nam KW, Kim CK, Ko SB, et al. Regional Arterial Spin Labeling Perfusion Defect Is Associated With Early Ischemic Recurrence in Patients With a Transient Ischemic Attack [J]. Stroke, 2020, 51(01): 186-192.
18
Niibo T, Ohta H, Yonenaga K, et al. Arterial spin-labeled perfusion imaging to predict mismatch in acute ischemic stroke [J]. Stroke, 2013, 44(09): 2601-2603.
19
Song K, Guan M, Li W, et al. Acute ischemic stroke patients with diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score </= 5 can benefit from endovascular treatment: a single-center experience and literature review [J]. Neuroradiology, 2019, 61(04): 451-459.
20
Puhr-Westerheide D, Tiedt S, Rotkopf LT, et al. Clinical and Imaging Parameters Associated With Hyperacute Infarction Growth in Large Vessel Occlusion Stroke [J]. Stroke, 2019, 50(10): 2799-2804.
21
Morofuji Y, Horie N, Tateishi Y, et al. Arterial Spin Labeling Magnetic Resonance Imaging Can Identify the Occlusion Site and Collateral Perfusion in Patients with Acute Ischemic Stroke: Comparison with Digital Subtraction Angiography [J]. Cerebrovasc Dis, 2019, 48(NaN): 70-76.
22
Niibo T, Ohta H, Miyata S, et al. Prediction of Blood-Brain Barrier Disruption and Intracerebral Hemorrhagic Infarction Using Arterial Spin-Labeling Magnetic Resonance Imaging [J]. Stroke, 2017, 48(01): 117-122.
23
Sobesky J, Thiel A, Ghaemi M, et al. Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusion [J]. J Cereb Blood Flow Metab, 2005, 25(12): 1685-1691.
24
Takasawa M, Watanabe M, Yamamoto S, et al. Prognostic value of subacute crossed cerebellar diaschisis: single-photon emission CT study in patients with middle cerebral artery territory infarct [J]. AJNR Am J Neuroradiol, 2002, 23(02): 189-193.
25
Strother MK, Buckingham C, Faraco CC, et al. Crossed cerebellar diaschisis after stroke identified noninvasively with cerebral blood flow-weighted arterial spin labeling MRI [J]. Eur J Radiol, 2016, 85(01): 136-142.
26
Shinohara Y, Kato A, Kuya K, et al. Perfusion MR Imaging Using a 3D Pulsed Continuous Arterial Spin-Labeling Method for Acute Cerebral Infarction Classified as Branch Atheromatous Disease Involving the Lenticulostriate Artery Territory [J]. AJNR Am J Neuroradiol, 2017, 38(08): 1550-1554.
27
Kang KM, Sohn CH, Choi SH, et al. Detection of crossed cerebellar diaschisis in hyperacute ischemic stroke using arterial spin-labeled MR imaging [J]. PloS One, 2017, 12(03): e0173971.
28
Berkhemer OA, Jansen IG, Beumer D, et al. Collateral Status on Baseline Computed Tomographic Angiography and Intra-Arterial Treatment Effect in Patients With Proximal Anterior Circulation Stroke [J]. Stroke, 2016, 47(03): 768-776.
29
Broocks G, Kemmling A, Meyer L, et al. Computed Tomography Angiography Collateral Profile Is Directly Linked to Early Edema Progression Rate in Acute Ischemic Stroke [J]. Stroke, 2019, 50(12): 3424-3430.
30
Flores A, Rubiera M, Ribo M, et al. Poor Collateral Circulation Assessed by Multiphase Computed Tomographic Angiography Predicts Malignant Middle Cerebral Artery Evolution After Reperfusion Therapies [J]. Stroke, 2015, 46(11): 3149-3153.
31
Deibler AR, Pollock JM, Kraft RA, et al. Arterial spin-labeling in routine clinical practice, part 3: hyperperfusion patterns [J]. AJNR Am J Neuroradiol, 2008, 29(08): 1428-1435.
32
Zaharchuk G, Do HM, Marks MP, et al. Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease [J]. Stroke, 2011, 42(09): 2485-2491.
33
Crisi G, Filice S, Scoditti U. Arterial Spin Labeling MRI to Measure Cerebral Blood Flow in Untreated Ischemic Stroke [J]. J Neuroimaging, 2019, 29(02): 193-197.
34
Nael K, Meshksar A, Liebeskind DS, et al. Periprocedural arterial spin labeling and dynamic susceptibility contrast perfusion in detection of cerebral blood flow in patients with acute ischemic syndrome [J]. Stroke, 2013, 44(03): 664-670.
35
Thamm T, Guo J, Rosenberg J, et al. Contralateral Hemispheric Cerebral Blood Flow Measured With Arterial Spin Labeling Can Predict Outcome in Acute Stroke [J]. Stroke, 2019, 50(12): 3408-3415.
36
Lee S, Park DW, Kim TY, et al. A novel visual ranking system based on arterial spin labeling perfusion imaging for evaluating perfusion disturbance in patients with ischemic stroke [J]. PloS One, 2020, 15(01): e0227747.
37
Yu S, Ma SJ, Liebeskind DS, et al. ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients [J]. J Cereb Blood Flow Metab, 2018, 38(03): 382-392.
38
Wang K, Shou Q, Ma SJ, et al. Deep Learning Detection of Penumbral Tissue on Arterial Spin Labeling in Stroke [J]. Stroke, 2019, 51(02):489-497.
39
Kanazawa Y, Arakawa S, Shimogawa T, et al. Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke from Epileptic Disorders [J]. J Stroke Cerebrovasc Diseases, 2019, 28(06): 1684-1690.
40
Tian B, Liu Q, Wang X, et al. Chronic intracranial artery stenosis: Comparison of whole-brain arterial spin labeling with CT perfusion [J]. Clin Imaging, 2018, 52: 252-259.
41
Lou X, Yu S, Scalzo F, et al. Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke [J]. Oncotarget, 2017, 08(02): 2437-2443.
42
Lyu J, Ma N, Liebeskind DS, et al. Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis [J]. Stroke, 2016, 47(02): 428-433.
43
Okell TW, Harston GWJ, Chappell MA, et al. Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study [J]. Sci Rep, 2019, 09(01): 8181.
[1] 丁建民, 秦正义, 张翔, 周燕, 周洪雨, 王彦冬, 经翔. 超声造影与普美显磁共振成像对具有高危因素的≤3 cm肝结节进行LI-RADS分类诊断的前瞻性研究[J]. 中华医学超声杂志(电子版), 2023, 20(09): 930-938.
[2] 张莲莲, 惠品晶, 丁亚芳. 颈部血管超声在粥样硬化斑块易损性评估中的应用价值[J]. 中华医学超声杂志(电子版), 2023, 20(08): 816-821.
[3] 刘冰茹, 刘皓希, 陈莹, 赖世伟, 陈蓉. 疑似乳腺癌的韧带样纤维瘤病一例[J]. 中华乳腺病杂志(电子版), 2023, 17(05): 314-317.
[4] 董晓燕, 赵琪, 唐军, 张莉, 杨晓燕, 李姣. 奥密克戎变异株感染所致新型冠状病毒感染疾病新生儿的临床特征分析[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 595-603.
[5] 韩宇, 张武, 李安琪, 陈文颖, 谢斯栋. MRI肝脏影像报告和数据系统对非肝硬化乙肝患者肝细胞癌的诊断价值[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 669-673.
[6] 雷漫诗, 邓锶锶, 汪昕蓉, 黄锦彬, 向青, 熊安妮, 孟占鳌. 人工智能辅助压缩感知技术在上腹部T2WI压脂序列中的应用[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 551-556.
[7] 尚慧娟, 袁晓冬. 机械取栓术后应用依达拉奉右崁醇对急性缺血性脑卒中预后的改善[J]. 中华神经创伤外科电子杂志, 2023, 09(05): 295-301.
[8] 廖家权, 吴波, 唐昌敏. 体外冲击波联合肌电生物反馈对脑卒中后足下垂的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 286-292.
[9] 钟广俊, 刘春华, 朱万森, 徐晓雷, 王兆军. MRI联合不同扫描序列在胃癌术前分期诊断及化疗效果和预后的评估[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 378-382.
[10] 吴钰娴, 冯亚园, 霍雷, 贾宁阳, 张娟. 原发性肝脏淋巴瘤的影像学诊断价值研究[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 349-353.
[11] 孙洪扬, 刘基, 龚字翔, 王广英, 宁召腾, 赵璇, 朱其义, 王贤军. 急性前循环大血管闭塞性轻型卒中血管内治疗的临床预后及手术时机选择[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 445-451.
[12] 孙畅, 赵世刚, 白文婷. 脑卒中后认知障碍与内分泌激素变化的关系[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 471-476.
[13] 张许平, 刘佳成, 张舸, 杜艳姣, 李韶, 商丹丹, 王浩, 李艳, 段智慧. CYP2C19基因多态性联合血栓弹力图指导大动脉粥样硬化型非致残性缺血性脑血管事件患者抗血小板治疗的效果[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 477-481.
[14] 杨海华, 袁景林, 周晓梅, 牛军伟. RNF213基因突变所致烟雾病一家系病例临床分析并文献复习[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 495-498.
[15] 金泽平, 董晶, 柳云鹏, 汪阳. 菌群-肠道-脑轴与缺血性卒中危险因素关系的研究进展[J]. 中华脑血管病杂志(电子版), 2023, 17(05): 510-517.
阅读次数
全文


摘要