Research progress in total burden assessment scale for cerebral small vessel disease

doi:10.11817/j.issn.1673-9248.2023.02.010

Abstract

Abstract:

With the in-depth study of the clinical, imaging, and pathophysiological mechanism of cerebral small vessel disease (CSVD) , it was found that the various imaging markers of CSVD were interrelated and interacted with each other, and they might have synergistic or superimposed effects on the clinical symptoms. Increasing evidence showed that CSVD was closely related to stroke recurrence, cognitive decline, dyskinesia, emotional abnormality, dysuria, and defecation disorder, which should therefore be treated as a whole brain disease. We reviewed the evaluation and clinical significance of CSVD imaging markers together with the research progress of CSVD total burden scoring methods, in order to provide some reference for further improvement of CSVD total burden score.

Key words: Cerebral small vessel disease, Total burden, Cerebral amyloid angiopathy

Hongmei Hu, Wenli Hu. Research progress in total burden assessment scale for cerebral small vessel disease[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2023, 17(02): 145-149.

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序号	文献	WMH	CMBs	EPVS	腔隙	急性腔隙性梗死	脑萎缩	皮质表面铁沉积	总分（分）
1	Kim等^[3]	PWMH≥3或DWMH≥2，1分	深部CMBs≥1个，1分	-	≥1个，1分	≥1个，1分	-	-	0~4
2	Hong等^[11]	中度WMH（总分3~4），1分；重度WMH（总分5~6），2分	1~4个，1分；≥5个，2分	BG-EPVS 11~20个，1分；BG-EPVS＞20个，2分	≥1个，1分	-	-	-	0~7
2	Hong等^[11]	中度WMH（总分3~4），1分；重度WMH（总分5~6），2分	1~4个，1分；≥5个，2分	（BG/CSO）-EPVS 11~20个，1分；（BG/CSO）-EPVS＞20个，2分	≥1个，1分	-	-	-
3	Zhi等^[12]	中度WMH（总分3~4分），1分；重度WMH（总分5~6分），2分	1~4个深部CMBs，1分；≥5个深部CMBs，2分	BG-EPVS＞20个，1分	≥1个，1分	-	-	-	0~6
4	Molad等^[18]	PWMH≥3或DWMH≥2，1分	≥1个，1分	（BG+CSO）-EPVS≥30个，1分	≥1个，1分	-	-	-	0~4
5	Xia等^[19]	PWMH≥3或DWMH≥2，1分	≥1个，1分	（BG/CSO）-EPVS＞20个，1分	≥1个，1分	-	-	-	0~4
6	Yang等^[26]	PWMH≥3或DWMH≥2，1分	深部CMBs≥1个，1分	BG-EPVS＞10个，1分	≥1个，1分	-	中重度，1分	-	0~5
7	Charidimou等^[31]	PWMH≥3或DWMH≥2，1分	2~4个脑叶CMBs，1分；≥5个脑叶CMBs，2分	CSO-EPVS＞20个，1分	-	-	-	≤3个脑沟；＞3个脑沟，2分	0~6
8	Staals等^[34]	PWMH≥3或DWMH≥2，1分	≥1个，1分	BG-EPVS＞10个，1分	≥1个，1分	-	-	-	0~4
9	Xu等^[35]	PWMH≥2或DWMH≥2，1分	≥1个，1分	BG-EPVS＞10个，1分	≥1个，1分	-	-	-	0~4

序号	文献	WMH	CMBs	EPVS	腔隙	急性腔隙性梗死	脑萎缩	皮质表面铁沉积	总分（分）
1	Kim等^[3]	PWMH≥3或DWMH≥2，1分	深部CMBs≥1个，1分	-	≥1个，1分	≥1个，1分	-	-	0~4
2	Hong等^[11]	中度WMH（总分3~4），1分；重度WMH（总分5~6），2分	1~4个，1分；≥5个，2分	BG-EPVS 11~20个，1分；BG-EPVS＞20个，2分	≥1个，1分	-	-	-	0~7
2	Hong等^[11]	中度WMH（总分3~4），1分；重度WMH（总分5~6），2分	1~4个，1分；≥5个，2分	（BG/CSO）-EPVS 11~20个，1分；（BG/CSO）-EPVS＞20个，2分	≥1个，1分	-	-	-
3	Zhi等^[12]	中度WMH（总分3~4分），1分；重度WMH（总分5~6分），2分	1~4个深部CMBs，1分；≥5个深部CMBs，2分	BG-EPVS＞20个，1分	≥1个，1分	-	-	-	0~6
4	Molad等^[18]	PWMH≥3或DWMH≥2，1分	≥1个，1分	（BG+CSO）-EPVS≥30个，1分	≥1个，1分	-	-	-	0~4
5	Xia等^[19]	PWMH≥3或DWMH≥2，1分	≥1个，1分	（BG/CSO）-EPVS＞20个，1分	≥1个，1分	-	-	-	0~4
6	Yang等^[26]	PWMH≥3或DWMH≥2，1分	深部CMBs≥1个，1分	BG-EPVS＞10个，1分	≥1个，1分	-	中重度，1分	-	0~5
7	Charidimou等^[31]	PWMH≥3或DWMH≥2，1分	2~4个脑叶CMBs，1分；≥5个脑叶CMBs，2分	CSO-EPVS＞20个，1分	-	-	-	≤3个脑沟；＞3个脑沟，2分	0~6
8	Staals等^[34]	PWMH≥3或DWMH≥2，1分	≥1个，1分	BG-EPVS＞10个，1分	≥1个，1分	-	-	-	0~4
9	Xu等^[35]	PWMH≥2或DWMH≥2，1分	≥1个，1分	BG-EPVS＞10个，1分	≥1个，1分	-	-	-	0~4

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