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中华脑血管病杂志(电子版) ›› 2020, Vol. 14 ›› Issue (05) : 297 -299. doi: 10.11817/j.issn.1673-9248.2020.05.009

所属专题: 文献

综述

脑小血管病排尿障碍的研究现状
赵弘轶1, 刘宇1, 黄勇华2,()   
  1. 1. 100094 北京,解放军第九八四医院神经内科
    2. 100700 北京,解放军总医院第七医学中心神经内科
  • 收稿日期:2020-08-08 出版日期:2020-10-01
  • 通信作者: 黄勇华
  • 基金资助:
    吴阶平医学基金会临床科研专项资助基金(320. 6750. 18456)

Progress in bladder dysfunction in cerebral small vessel disease

Hongyi Zhao1, Yu Liu1, Yonghua Huang2,()   

  1. 1. Department of Neurology, NO.984 Hospital of PLA, Beijing 100094, China
    2. Department of Neurology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China
  • Received:2020-08-08 Published:2020-10-01
  • Corresponding author: Yonghua Huang
  • About author:
    Corresponding author: Huang Yonghua, Email:
引用本文:

赵弘轶, 刘宇, 黄勇华. 脑小血管病排尿障碍的研究现状[J]. 中华脑血管病杂志(电子版), 2020, 14(05): 297-299.

Hongyi Zhao, Yu Liu, Yonghua Huang. Progress in bladder dysfunction in cerebral small vessel disease[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2020, 14(05): 297-299.

排尿障碍被认为是脑小血管病(CSVD)的主要临床表现之一,但以往并未得到研究者的足够重视。近年来的一些研究显示,CSVD患者中排尿障碍的发生比例很高,严重影响患者的日常生活和社会功能。CSVD患者排尿障碍的临床特点主要表现为膀胱过度活动症和尿失禁等,发生机制与额叶皮层、中扣带回、皮层下环路结构和功能受损有关。本文拟对CSVD患者排尿障碍的临床发生情况进行综述,为CSVD的临床诊治拓展新的思路。

Bladder dysfunction is considered as one of the major manifestations in cerebral small vessel disease (CSVD), though it has not gained enough attention of researchers previously. Recently investigations have exhibited the high prevalence of bladder dysfunction, which impacted severely daily life and social function of patients with CSVD. The clinical features of bladder dysfunction in CSVD are overactive bladder and incontinence, which is caused by dysfunction and deconstruction of circuits related to frontal cortex, medial cingulate gyrus and subcortex. The present paper reviews the clinical manifestations of bladder dysfunction in patients with CSVD, so as to broaden the concept of diagnosis and therapy in CSVD.

1
中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑小血管病诊治共识 [J]. 中华神经科杂志, 2015, 48(10): 838-844.
2
Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration [J]. Lancet Neurol, 2013, 12(8): 822-838.
3
Han F, Zhai FF, Wang Q, et al. Prevalence and risk factors of cerebral small vessel disease in a Chinese population-based sample [J]. J Stroke, 2018, 20(2): 239-246.
4
黄勇华, 赵弘轶. 脑小血管病研究新理念 [J]. 中国现代神经疾病杂志, 2019, 19(7): 461-465.
5
Van Leijsen EM, Bergkamp MI, Van Uden IW, et al. Cognitive consequences of regression of cerebral small vessel disease [J]. Eur Stroke J, 2019, 4(1): 85-89.
6
王伊龙. 重视脑小血管病的步态障碍 [J]. 中华医学杂志, 2019, 99(9): 641-643.
7
夏振西, 黄敏莹, 赵弘轶, 等. 脑小血管病患者淡漠综合征的临床评定 [J]. 中国卒中杂志, 2020, 15(4): 354-359.
8
Kitta T, Mitsui T, Kanno Y, et al. Brain-bladder control network: The unsolved 21st century urological mystery [J]. Int J Urol, 2015, 22(4): 342-348.
9
田雨, 管玲, 王伊龙. 脑小血管病排尿与排便障碍研究现状及机制探索 [J]. 中国卒中杂志, 2019, 14(11): 1129-1134.
10
Milsom I, Abrams P, Cardozo L, et al. How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study [J]. BJU Int, 2001, 87(9): 760-766.
11
Sakakibara R, Panicker J, Fowler CJ, et al. Vascular incontinence: incontinence in the elderly due to ischemic white matter changes [J]. Neurol Int, 2012, 4(2): e13.
12
Sakakibara R, Panicker J, Fowleret CJ, et al. “Vascular incontinence” and normal-pressure hydrocephalus: two common sources of elderly incontinence with brain etiologies [J]. Curr Drug Ther, 2012, 7: 67-76.
13
Sakakibara R, Hattori T, Uchiyama T, et al. Urinary function in the elderly with and without leukoaraiosis; in relation to cognitive and gait function [J]. J Neurol Neurosurg Psychiatry, 1999, 67(5): 658-660.
14
Wehrberger C, Jungwirth S, Fischer P, et al. The relationship between cerebral white matter hyperintensities and lower urinary tract function in a population based, geriatric cohort [J]. Neurourol Urodyn, 2014, 33(4): 431-436.
15
Kuchel GA, Moscufo N, Guttmann CR, et al. Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults [J]. J Gerontol A Biol Sci Med Sci, 2009, 64(8): 902-909.
16
Tadic SD, Griffiths D, Murrin A, et al. Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence [J]. NeuroImage, 2010, 51(4): 1294-1302.
17
Wakefield DB, Moscufo N, Guttmann CR, et al. White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults [J]. J Am Geriatr Soc, 2010, 58(2): 275-281.
18
Itoh Y, Yamada S, Konoeda F, et al. Burden of overactive bladder symptom on quality of life in stroke patients [J]. Neurourol Urodyn, 2013, 32(5): 428-434.
19
Clarkson BD, Griffiths D, Resnick NM. Do brain structural abnormalities differentiate separate forms of urgency urinary incontinence? [J]. Neurourol Urodyn, 2018, 37(8): 2597-2605.
20
Smith PP, Kuchel GA, Griffiths D. Functional brain imaging and the neural basis for voiding dysfunction in older adults [J]. Clin Geriatr Med, 2015, 31(4): 549-565.
21
Haruta H, Sakakibara R, Ogata T, et al. Inhibitory control task is decreased in vascular incontinence patients [J]. Clin Auton Res, 2013, 23(2): 85-89.
22
Homma Y, Yamaguchi O, Imidafenacin Study Group. A randomized, double-blind, placebo- and propiverine controlled trial of the novel antimuscarinic agent imidafenacin in Japanese patients with overactive bladder [J]. Int J Urol, 2009, 16(5): 499-506.
23
Chancellor M, Boone T. Anticholinergics for overactive bladder therapy: central nervous system effects [J]. CNS Neurosci Ther, 2012, 18(2): 167-174.
24
赵弘轶, 刘宇, 黄勇华. 脑小血管病相关头晕症状的研究进展 [J]. 中国卒中杂志, 2019, 14(11): 1186-1189.
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